Tero Aittokallio
PhD
teanai@utu.fi Tykistökatu 6 A Turku ORCID identifier: https://orcid.org/orcid.org/0000-0002-0886-9769 |
Tero Aittokallio received his PhD in Applied Mathematics from the University of Turku in 2001, under the supervision of Prof. Mats Gyllenberg. He then did his post-doctoral training in the Systems Biology Lab at the Institut Pasteur (2006-2007), with Dr. Benno Schwikowski, where he focused on network biology applications using high-throughput experimental assays and network analysis tools such as Cytoscape. In 2007, Dr. Aittokallio launched his independent career as a principal investigator in the Turku Biomathematics Research Group, where he received a five-year appointment as an Academy of Finland Research Fellow (2007-2012). Tero Aittokallio joined Institute for Molecular Medicine Finland (FIMM) as EMBL Group Leader in the fall of 2011, and was selected as Professor of Statistics and Applied Mathematics at University of Turku in 2015.
Aittokallio's research group focuses on developing and applying integrated computational-experimental approaches to tackle biomedical questions, such as how genes function as interaction networks to carry out and regulate cellular processes, how alterations in these networks contribute to complex traits, such as human diseases, and where and how in the disease network one should target to optimally inhibit the disease phenotypes, such as tumor growth.
Computational statistics.
Scientific computing.
- Drug-sensitivity screening and genomic characterization of 45 hpV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy (2018)
- Molecular Cancer Therapeutics
(A1 Refereed original research article in a scientific journal) - Drug Target Commons 2.0: a community platform for systematic analysis of drug target interaction profiles (2018)
- Database: The Journal of Biological Databases and Curation
(A1 Refereed original research article in a scientific journal) - Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions (2018)
- Cell Chemical Biology
(A1 Refereed original research article in a scientific journal) - ePCR: an R-package for survival and time-to-event prediction in advanced prostate cancer, applied to real-world patient cohorts (2018)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - Global proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach (2018)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML (2018)
- Leukemia
(A1 Refereed original research article in a scientific journal) - Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery (2018)
- Expert Opinion on Drug Discovery
(A2 Refereed review article in a scientific journal ) - Learning with multiple pairwise kernels for drug bioactivity prediction (2018)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - Methods for high-throughput drug combination screening and synergy scoring (2018) Cancer Systems Biology Liye He, Evgeny Kulesskiy, Jani Saarela, Laura Turunen, Krister Wennerberg, Tero Aittokallio, Jing Tang
(A3 Refereed book chapter or chapter in a compilation book) - Novel activities of safe-in-human broad-spectrum antiviral agents (2018)
- Antiviral Research
(A1 Refereed original research article in a scientific journal) - Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients (2018)
- Cancer Research
(A1 Refereed original research article in a scientific journal) - PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells (2018)
- Science Translational Medicine
(A1 Refereed original research article in a scientific journal) - Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis (2018)
- Human Reproduction
(A1 Refereed original research article in a scientific journal) - Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, ismodifiable, and associates with future cardiovascular deaths (2018)
- European Heart Journal
(A1 Refereed original research article in a scientific journal) - A community challenge for inferring genetic predictors of gene essentialities through analysis of a functional screen of cancer cell lines (2017)
- Cell Systems
(A1 Refereed original research article in a scientific journal) - Computational-experimental approach to drug-target interaction mapping: A case study on kinase inhibitors (2017)
- PLoS Computational Biology
(A1 Refereed original research article in a scientific journal) - C-SPADE: a web-tool for interactive analysis and visualization of drug screening experiments through compound-specific bioactivity dendrograms (2017)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - Early metabolic markers identify potential targets for the prevention of type 2 diabetes (2017)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML (2017)
- Leukemia
(A1 Refereed original research article in a scientific journal) - In Search of System-Wide Productivity Gains - The Role of Global Collaborations in Preclinical Translation (2017)
- Clinical and Translational Science
(B1 Non-refereed article in a scientific journal)