Eriika Savontaus
Vice dean of Education (MD and DDS programmes)
Research Center for Intergrative Physiology and Pharmacology erisan@utu.fi +358 29 450 4659 +358 50 401 2195 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0003-3421-0367 |
pharmacology; drug therapeutics; obesity; diabetes; cardiovascular diseases, in vivo disease models
Eriika Savontaus received MD in 1995 and PhD in 1999 at University of Turku. She got her post-doctoral training at Columbia University, Division of Molecular Genetics, New York, NY, USA 2000-2002. She established her own laboratory in the Department of Pharmacology and Clinical Pharmacology in 2003. Savontaus received the title of docent in Pharmacology in 2008. She has served as Senior/Clinical Lecturer (9/03-9/05, 3/09-7/09, 2/15-5/17), Academy Research Fellow (1/07-7/07, 8/09-1/15), acting Professor in Pharmacology (8/07-2/09) and Clinical pharmacology and therapeutics (8/19-7/20). Savontaus was tenured 6/2017 and nominated the Professor of Pharmacology and Therapeutics in 2021. She has a part-time affiliation as a physician in Clinical Pharmacology in University Hospital of Turku.
Obesity with related metabolic and cardiovascular diseases is an increasing problem, but current means to prevent and treat obesity are clearly insufficient. Research of Savontaus group aims to identifying novel means of intervention. The main interest is in two neuropeptides, NPY (neuropeptide Y) and POMC (melanocortins), that play key roles in the regulation of body weight. They are working to understand the tissue-specific mechanisms of NPY and melanocortin action in order to facilitate drug development for metabolic and cardiovascular diseases. Furthermore, the aim is to understand the impact of the genetics and epigenetics of these genes on the risk of cardiometabolic diseases and whether the epigenetic inheritance of metabolic diseases could be prevented.
Eriika Savontaus serves and vice dean in the faculty of medicine with responsibility of graduate degree education in medicine and dentistry. She teaches pharmacology, clinical pharmacology and therapeutics in medical, dental and biomedical curricula. She is involved in organizing doctoral training as the director of Drug Research Doctoral Program. She has supervised PhD thesis of six doctoral candidates and Master's thesis of 11 students.
- Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice (2014)
- Arteriosclerosis, Thrombosis, and Vascular Biology
(A1 Refereed original research article in a scientific journal) - Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neurons (2014)
- Molecular Metabolism
(A1 Refereed original research article in a scientific journal) - The effects of equal caloric high fat and western diet on metabolic syndrome, oxidative stress and vascular endothelial function in mice (2014)
- Acta Physiologica
(A1 Refereed original research article in a scientific journal) - α-MSH overexpression in the nucleus tractus solitarius decreases fat mass and elevates heart rate. (2014)
- Journal of Endocrinology
(A1 Refereed original research article in a scientific journal) - alpha-MSH Analogue Attenuates Blood Pressure Elevation in DOCA-Salt Hypertensive Mice (2013)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Genetic and pharmacological mouse models of chronic melanocortin activation show enhanced baroreflex control of heart rate (2013)
- Regulatory Peptides
(A1 Refereed original research article in a scientific journal) - Lentivirus-Mediated alpha-Melanocyte-Stimulating Hormone Overexpression in the Hypothalamus Decreases Diet Induced Obesity in Mice (2013)
- Journal of Neuroendocrinology
(A1 Refereed original research article in a scientific journal) - Pharmacological treatment with a melanocortin analogue protects against pressure-overload-induced cardiac hypertrophy (2013)
- FASEB Journal
(Other publication) - α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction (2013)
- Cardiovascular Research
(A1 Refereed original research article in a scientific journal) - Bone-specific overexpression of NPY modulates osteogenesis. (2012)
- The Journal of Musculoskeletal and Neuronal Interactions
(A1 Refereed original research article in a scientific journal) - Diet-induced obesity in mice overexpressing neuropeptide y in noradrenergic neurons (2012) Suvi T. Ruohonen, Laura H. Vähätalo, Eriika Savontaus
(A1 Refereed original research article in a scientific journal) - Hemodynamic actions and mechanisms of systemically administered alpha-MSH analogs in mice (2012)
- Peptides
(A1 Refereed original research article in a scientific journal) - Involvement of α2-adrenoceptor subtypes A and C in glucose homeostasis and adrenaline-induced hyperglycaemia. (2012)
- Neuroendocrinology
(A1 Refereed original research article in a scientific journal) - MMP-13 regulates growth of wound granulation tissue and modulates gene expression signatures involved in inflammation, proteolysis, and cell viability (2012)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Neuropeptide Y in the noradrenergic neurons induces the development of cardiometabolic diseases in a transgenic mouse model (2012) Ruohonen Saku Tuomas, Pesonen Ullamari, Savontaus Eriika
(A1 Refereed original research article in a scientific journal) - Regulation of prolactin in mice with altered hypothalamic melanocortin activity. (2012)
- Peptides
(A1 Refereed original research article in a scientific journal) - Metabolic regulation in progression to autoimmune diabetes (2011)
- PLoS Computational Biology
(A1 Refereed original research article in a scientific journal) - Acute hormonal changes following intravenous glucose challenge in lean and obese human subjects (2010)
- Scandinavian Journal of Clinical and Laboratory Investigation
(A1 Refereed original research article in a scientific journal) - Transgenic mice overexpressing neuropeptide Y in noradrenergic neurons - A novel model of increased adiposity and impaired glucose tolerance (2008)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Effects of intravenous glucose on Dopaminergic function in the human brain in vivo (2007)
- Synapse
(A1 Refereed original research article in a scientific journal)