Eriika Savontaus
Vice dean of Education (MD and DDS programmes)
Research Center for Intergrative Physiology and Pharmacology erisan@utu.fi +358 29 450 4659 +358 50 401 2195 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0003-3421-0367 |
pharmacology; drug therapeutics; obesity; diabetes; cardiovascular diseases, in vivo disease models
Eriika Savontaus received MD in 1995 and PhD in 1999 at University of Turku. She got her post-doctoral training at Columbia University, Division of Molecular Genetics, New York, NY, USA 2000-2002. She established her own laboratory in the Department of Pharmacology and Clinical Pharmacology in 2003. Savontaus received the title of docent in Pharmacology in 2008. She has served as Senior/Clinical Lecturer (9/03-9/05, 3/09-7/09, 2/15-5/17), Academy Research Fellow (1/07-7/07, 8/09-1/15), acting Professor in Pharmacology (8/07-2/09) and Clinical pharmacology and therapeutics (8/19-7/20). Savontaus was tenured 6/2017 and nominated the Professor of Pharmacology and Therapeutics in 2021. She has a part-time affiliation as a physician in Clinical Pharmacology in University Hospital of Turku.
Obesity with related metabolic and cardiovascular diseases is an increasing problem, but current means to prevent and treat obesity are clearly insufficient. Research of Savontaus group aims to identifying novel means of intervention. The main interest is in two neuropeptides, NPY (neuropeptide Y) and POMC (melanocortins), that play key roles in the regulation of body weight. They are working to understand the tissue-specific mechanisms of NPY and melanocortin action in order to facilitate drug development for metabolic and cardiovascular diseases. Furthermore, the aim is to understand the impact of the genetics and epigenetics of these genes on the risk of cardiometabolic diseases and whether the epigenetic inheritance of metabolic diseases could be prevented.
Eriika Savontaus serves and vice dean in the faculty of medicine with responsibility of graduate degree education in medicine and dentistry. She teaches pharmacology, clinical pharmacology and therapeutics in medical, dental and biomedical curricula. She is involved in organizing doctoral training as the director of Drug Research Doctoral Program. She has supervised PhD thesis of six doctoral candidates and Master's thesis of 11 students.
- Increased Energy Expenditure, Lipolysis and Hyperinsulinemia Confer Resistance to Central Obesity and Type 2 Diabetes in Mice Lacking Alpha2α-Adrenoceptors (2018)
- Neuroendocrinology
(A1 Refereed original research article in a scientific journal) - JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche (2018)
- Molecular Psychiatry
(A1 Refereed original research article in a scientific journal) - Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
(A1 Refereed original research article in a scientific journal) - Melanocortin overexpression limits diet-induced inflammation and atherosclerosis in LDLR-/- mice (2018)
- Journal of Endocrinology
(A1 Refereed original research article in a scientific journal) - Metformin normalizes the structural changes in glycogen preceding prediabetes in mice overexpressing neuropeptide Y in noradrenergic neurons (2018)
- Pharmacology Research and Perspectives
(A1 Refereed original research article in a scientific journal) - Osteoporoosin hoidossa käytettävät lääkeaineet (2018) Farmakologia ja toksikologia Savontaus E
(D2 Article in a professional compilation book) - Peripherally Administered Y-2-Receptor Antagonist BIIE0246 Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but Enhances Obesity in Control Mice (2018)
- Frontiers in Pharmacology
(A1 Refereed original research article in a scientific journal) - Tietoruutu L47. Insuliini (2018) Farmakologia ja toksikologia Savontaus E, Rouru J
(D2 Article in a professional compilation book) - Vitamiinit (2018) Farmakologia ja toksikologia Freese R, Savontaus E.
(D2 Article in a professional compilation book) - Diabetes, lihavuus ja metabolinen oireyhtymä (2017) Lääketieteellinen farmakologia ja toksikologia Savontaus Eriika, Huupponen Risto
(D2 Article in a professional compilation book) - Endokriiniseen järjestelmään vaikuttavat lääkeaineet (2017) Lääketieteellinen farmakologia ja toksikologia Huupponen Risto, Savontaus Eriika
(D2 Article in a professional compilation book) - Lääketieteellinen farmakologia ja toksikologia (2017) Heikki Ruskoaho, Jukka Hakkola, Risto Huupponen, Anu Kantele, Esa Korpi, Eeva Moilanen, Petteri Piepponen, Eriika Savontaus, Olli Tenhunen, Kirsi Vähäkangas
(D6 Editorial work for a professional compilation book) - The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons (2017)
- Journal of Endocrinology
(A1 Refereed original research article in a scientific journal) - Tyypin 2 diabeksen lääkevalikoima monipuolistuu - yhdistelmistä tehoa hoitoon (2017)
- Diabetes ja lääkäri
(D1 Article in a professional journal) - Neuropeptide Y in noradrenergic neurons induces obesity in transgenic mouse models (2016)
- Neuropeptides
(A2 Refereed review article in a scientific journal ) - Neuropeptide Y Overexpressing Female and Male Mice Show Divergent Metabolic but Not Gut Microbial Responses to Prenatal Metformin Exposure (2016)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans (2015)
- Arteriosclerosis, Thrombosis, and Vascular Biology
(A1 Refereed original research article in a scientific journal) - Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice. – Noradrenergic neurone NPY and obesity (2015)
- Acta Physiologica
(A1 Refereed original research article in a scientific journal) - Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons (2015)
- Nutrition and Diabetes
(A1 Refereed original research article in a scientific journal) - Neuropeptide Y Attenuates Stress-Induced Bone Loss Through Suppression of Noradrenaline Circuits (2014)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal)