Pekka Taimen
MD, PhD
pepeta@utu.fi +358 29 450 4524 +358 50 431 1353 Kiinamyllynkatu 10 Turku Työhuone: D5019 ORCID-tunniste: https://orcid.org/0000-0001-8849-4604(external) Official web page of research group(external) |
pathology; histology; cell biology; prostate cancer, bladder cancer, cardiomyopathy, nuclear lamin
Pekka Taimen received his MD degree from the University of Turku in 2001 and defended his thesis at the Department of Pathology, University of Turku in 2004. In 2008-2009 PT worked as a postdoctoral fellow in the laboratory of Prof. Robert D. Goldman, Northwestern University Medical School, Chicago. Postdoctoral studies focusing on nuclear intermediate filament proteins called lamins were further continued as a junior group leader after returning back to Turku in early 2010. In 2011 PT received a specialist degree in Pathology and since then he has worked as a part-time specialist at the Pathology Division, Turku University Hospital with special focus on uropathology. From 2012 PT has worked as a Clinical lecturer in Pathology and between 2015-2019 as a part-time Academy of Finland Clinical Researcher. PT was appointed as a tenure track Assistant Professor of Molecular Pathology in January 2019 and an Associate Professor in August 2020. In January 2022, PT was appointed as a Professor of Molecular Pathology and he currently serves as the head of the pathology unit at the Faculty of Medicine, University of Turku.
Professor Pekka Taimen has 20 years of experience in cell and molecular biology as well as in translational research. The main focus of his research group is on human diseases caused by lamin mutations, such as cardiomyopathies and premature aging syndrome. More recently, PT has also actively worked on prostate and bladder cancer related projects including novel biomarkers, biobanking, patient derived cell lines and improved imaging techniques utilizing digital pathology and machine learning approaches.
Pekka Taimen has more than 10 years of experience in teaching medical students at the Institute of Biomedicine, University of Turku. He has served first as a university teacher and from 2012 as a clinical lecturer. In 2015 PT received the Lecturer of the Year award in the Faculty of Medicine.
- Novel Biparametric MRI and Targeted Biopsy Improves Risk Stratification in Men With a Clinical Suspicion of Prostate Cancer (IMPROD Trial) (2017)
- Journal of Magnetic Resonance Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Radiomic features for prostate cancer detection on MRI differ between the transition and peripheral zones: Preliminary findings from a multi-institutional study (2017)
- Journal of Magnetic Resonance Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy (2016)
- Journal of Cell Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Diffusion Weighted Imaging of Prostate Cancer: Prediction of Cancer using Texture Features from Parametric Maps of the Monoexponential and Kurtosis functions (2016) 2016 Sixth International Conference on Image Processing Theory, Tools and Applications (IPTA) Ileana Montoya Perez, Jussi Toivonen, Parisa Movahedi, Harri Merisaari, Marko Pesola, Pekka Taimen, Peter J. Boström, Aida Kiviniemi, Hannu J. Aronen, Tapio Pahikkala, Ivan Jambor
(A4 Vertaisarvioitu artikkeli konferenssijulkaisussa) - Establishment of a realistic patient derived xenograft (PDX) model for prostate cancer bone metastasis (2016)
- Cancer Research
(O2 Muu julkaisu ) - Global expression of AMACR transcripts predicts risk for prostate cancer - a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate (2016)
- BMC Urology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy (2016)
- International Journal of Cancer
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway (2016)
- Carcinogenesis
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Loss of PTEN expression in ERG-negative prostate cancer predicts secondary therapies and leads to shorter disease-specific survival time after radical prostatectomy. (2016)
- Modern Pathology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Patient-specific pharmacokinetic parameter estimation on dynamic contrast-enhanced MRI of prostate: Preliminary evaluation of a novel AIF-free estimation method (2016)
- Journal of Magnetic Resonance Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Relaxation along fictitious field, diffusion-weighted imaging, and T2 mapping of prostate cancer: Prediction of cancer aggressiveness (2016)
- Magnetic Resonance in Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Rotating frame relaxation imaging of prostate cancer: Repeatability, cancer detection, and Gleason score prediction (2016)
- Magnetic Resonance in Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Stratification of aggressive prostate cancer from indolent disease-Prospective controlled trial utilizing expression of 11 genes in apparently benign tissue (2016)
- Urologic Oncology: Seminars and Original Investigations
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs (2016)
- Frontiers in Pharmacology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Validation of Novel Biomarkers for Prostate Cancer Progression by the Combination of Bioinformatics, Clinical and Functional Studies (2016)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Altered PCA3 and TMPRSS2-ERG expression in histologically benign regions of cancerous prostates: a systematic, quantitative mRNA analysis in five prostates (2015)
- BMC Urology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Differential predictive roles of A- and B-type nuclear lamins in prostate cancer progression (2015)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Diffusion-weighted imaging of prostate cancer: effect of b-value distribution on repeatability and cancer characterization (2015)
- Magnetic Resonance Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Evaluation of different mathematical models for diffusion-weighted imaging of normal prostate and prostate cancer using high b-values: A repeatability study (2015)
- Magnetic Resonance in Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells (2015)
- Nucleus
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )