MD, professor, Turku PET Centre Juhani Knuuti - UTU Research Portal

Juhani Knuuti
MD, professor, Turku PET Centre

- Director,
- Professor,
Turku PET Centre (Independent units)
- ,
InFLAMES Flagship (Faculty of Medicine)

jknuuti@utu.fi

+358 29 450 2345

+358 50 059 2998

Kiinamyllynkatu 4-8

Turku

: https://orcid.org/0000-0003-3156-9593

CV J Knuuti 5th February 2021_signed.pdf

Cardiovascular diseases, imaging

Juhani Knuuti’s research has focused on the physiology and pathophysiology, diagnosis and new therapies of coronary artery disease, heart failure and metabolic diseases. The research is also focused on developing and utilizing novel noninvasive imaging methods (PET, SPECT, echocardiography, MRI and CT) that will help to determine the risk and severity of CHD and heart failure and provide guidance for therapy decisions. The recent focus in cardiac research has been on vulnerable plaques, cardiac remodelling and multimodality and hybrid imaging. In metabolic and diabetes research, the focus has been in the interactions between different organs and heart in the pathogenesis and development of the cardiac diseases.

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Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) IMAGE HF Project I-A: study protocol for a randomized controlled trialGene transfer using vammin induces robust angiogenesis and increases ejection fraction in ischemic porcine myocardium (2013)
- TrialsEuropean Heart Journal
O'Meara E, Mielniczuk LM, Wells GA, deKemp RA, Klein R, Coyle D, Mc Ardle B, Paterson I, White JA, Arnold M, Friedrich MG, Larose E, Dick A, Chow B, Dennie C, Haddad H, Ruddy T, Ukkonen H, Wisenberg G, Cantin B, Pibarot P, Freeman M, Turcotte E, Connelly K, Clarke J, Williams K, Racine N, Garrard L, Tardif JC, DaSilva J, Knuuti J, Beanlands R
Anatomic Versus Physiologic Assessment of Coronary Artery Disease: Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making (2013)
- Journal of the American College of Cardiology
Gould KL, Johnson NP, Bateman TM, Beanlands RS, Bengel FM, Bober R, Camici PG, Cerqueira MD, Chow BJW, Di Carli MF, Dorbala S, Gewirtz H, Gropler RJ, Kaufmann PA, Knaapen P, Knuuti J, Merhige ME, Rentrop KP, Ruddy TD, Schelbert HR, Schindler TH, Schwaiger M, Sdringola S, Vitarello J, Williams KA, Gordon D, Dilsizian V, Narula J
Athlete's heart: adaptations in blood flow, oxygen utilization, and efficiency at rest and during exercise (2013)
- FASEB JournalDialogues in cardiovascular medicine
Heinonen I, Kudomi N, Kemppainen J, Luotolahti M, Sipila H, Duncker DJ, Knuuti J, Kalliokoski KK
Cardiac computed tomography: Is the calcium score index outweighed by noninvasive angiography? (2013)
Saraste A., Knuuti J.
Cardiac Imaging and Stress Testing Asymptomatic Athletes to Identify Those at Risk of Sudden Cardiac DeathComputation of myocardial blood flow and metabolic rate of O2 in right ventricle at rest and during exercise using H215O and 15O2 PET (2013)
- JACC: Cardiovascular Imaging
La Gerche A, Baggish AL, Knuuti J, Prior DL, Sharma S, Heidbuchel H, Thompson PD
Combined functional and anatomical imaging for the detection and guiding the therapy of coronary artery disease (2013)
- European Heart JournalTrialsEuropean Journal of Nuclear Medicine and Molecular Imaging
Knuuti J, Saraste A
(2013) European Journal of Nuclear Medicine and Molecular Imaging Kudomi N, Kalliokoski KK, Oikonen VJ, Han C, Kemppainen J, Luotolahti M, Sipila H, Duncker DJ, Knuuti J, Heinonen I
Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C) (2013)
Chow BJW, Green RE, Coyle D, Laine M, Hanninen H, Leskinen H, Rajda M, Larose E, Hartikainen J, Hedman M, Mielniczuk L, O'Meara E, deKemp RA, Klein R, Paterson I, White JA, Yla-Herttuala S, Leber A, Tandon V, Lee T, Al-Hesayen A, Hessian R, Dowsley T, Kass M, Kelly C, Garrard L, Tardif JC, Knuuti J, Beanlands RS, Wells GA
Effect of nitric oxide synthase inhibition on the exchange of glucose and fatty acids in human skeletal muscle.ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation Guía de práctica clínica de la ESC para el manejo del infarto agudo de miocardio en pacientes con elevación del segmento ST: Grupo de Trabajo para el manejo del infarto agudo de miocardio con elevación del segmento ST de la Sociedad Europea de Cardiología (ESC) (2013)
- Nutrition and MetabolismEuropean Heart Journal
Heinonen I, Saltin B, Kemppainen J, Nuutila P, Knuuti J, Kalliokoski K, Hellsten Y
Effects of high-intensity interval training on myocardial vascular function [YIA competitor], oral presentation OP-PM24-3 (2013) 18th Annual Congress of the European College of Sport Science Eskelinen JJ, Hannukainen JC, Savolainen A, Heinonen I, Virtanen KA, Kemppainen J, Koivumäki M, Kapanen J, Knuuti J, Kalliokoski KK
(2013)
- Revista Española de Cardiología
Steg PG, James SK, Atar D, Badano LP, Lundqvist CB, Borger MA, di Mario C, Dickstein K, Ducrocq G, Fernandez-Aviles F, Gershlick AH, Giannuzzi P, Halvorsen S, Huber K, Juni P, Kastrati A, Knuuti J, Lenzen MJ, Mahaffey KW, Valgimigli M, van't Hof A, Widimsky P, Zahger D, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, Hasdai D, Astin F, Astrom-Olsson K, Budaj A, Clemmensen P, Collet JP, Fox KA, Fuat A, Gustiene O, Hamm CW, Kala P, Lancellotti P, Maggioni AP, Merkely B, Neumann FJ, Piepoli MF, van de Werf F, Verheugt F, Wallentin L
ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD (2013)
- European Heart Journal
Ryden L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, Deaton C, Escaned J, Hammes HP, Huikuri H, Marre M, Marx N, Mellbin L, Ostergren J, Patrono C, Seferovic P, Uva MS, Taskinen MR, Tendera M, Tuomilehto J, Valensi P, Zamorano JL
Exercise training improves insulin sensitivity in abdominal adipose tissue but not in brown adipose tissue in healthy, sedentary, middle aged men (2013)
- Diabetologia
Abstracts of the 49th Annual Meeting of the EASD Motiani KK, Savolainen A, Eskelinen JJ, Virtanen KA, Bostrom P, Jensen J, Parkkola R, Saunavaara V, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC
(2013)
Eur Heart J (2013) 34 (suppl 1) Halonen P, Nurro J, Kuivanen A, Toivanen P, Nieminen T, Tarkia M, Rissanen TT, Knuuti J, Yla-Herttuala S
Hybrid CT angiography and quantitative O-15-water PET for assessment of coronary artery disease: comparison with quantitative coronary angiographyInaccuracy in parameter estimation with background subtraction method in dual injection PET based on simulation study (2013)
- European Journal of Nuclear Medicine and Molecular ImagingEuropean Journal of Nuclear Medicine and Molecular Imaging
Thomassen A, Petersen H, Diederichsen ACP, Mickley H, Jensen LO, Johansen A, Gerke O, Braad PE, Thayssen P, Hoilund-Carlsen MM, Vach W, Knuuti J, Hoilund-Carlsen PF
Hybrid SPECT/CT and PET/CT imaging (2013) Atlas of Nuclear Cardiology Knuuti J
(2013)
European Journal of Nuclear Medicine and Molecular Imaging Huang X, Merisaari H, Oikonen V, Teras M, Tolvanen T, Saraste A, Knuuti J, Han C
Inhibition of alpha-adrenergic tone disturbs the distribution of blood flow in the exercising human limb (2013)
- AJP - Regulatory, Integrative and Comparative Physiology
Heinonen I, Wendelin-Saarenhovi M, Kaskinoro K, Knuuti J, Scheinin M, Kalliokoski KK
Interobserver reproducibility of myocardial perfusion quantification with N-13-ammonia and Rb-82 PET studied with Carimas (2013)
European Journal of Nuclear Medicine and Molecular Imaging, Volume 40, Supplement 2 Nesterov SV, Deshayes E, Settimo L, Han C, Ryzhkova DV, Kostina IS, Maki M, Prior JO, Sciagra R, Knuuti J
Is cardiac magnetic resonance imaging causing DNA damage? (2013)
Knuuti J, Saraste A, Kallio M, Minn H