Juhani Knuuti
MD, professor, Turku PET Centre
Cardiovascular diseases, imaging
Juhani Knuuti’s research has focused on the physiology and pathophysiology, diagnosis and new therapies of coronary artery disease, heart failure and metabolic diseases. The research is also focused on developing and utilizing novel noninvasive imaging methods (PET, SPECT, echocardiography, MRI and CT) that will help to determine the risk and severity of CHD and heart failure and provide guidance for therapy decisions. The recent focus in cardiac research has been on vulnerable plaques, cardiac remodelling and multimodality and hybrid imaging. In metabolic and diabetes research, the focus has been in the interactions between different organs and heart in the pathogenesis and development of the cardiac diseases.
- 18F-FDG PET/CT in the diagnosis of infective endocarditis (2024) Salminen, Linnea; Ballo, Haitham; Maaniitty,Teemu; Vasankari, Tuija; Elnammas, Wail; Knuuti, Juhani; Hohenthal, Ulla; Saraste, Antti
- Age and Computed Tomography and Invasive Coronary Angiography in Stable Chest Pain: A Prespecified Secondary Analysis of the DISCHARGE Randomized Clinical Trial (2024) DISCHARGE Trial Group, Bosserdt M, Serna-Higuita LM, Feuchtner G, Merkely B, Kofoed KF, Benedek T, Donnelly P, Rodriguez-Palomares J, Erglis A, Štechovský C, Šakalyte G, Adic NC, Gutberlet M, Dodd JD, Diez I, Davis G, Zimmermann E, Kepka C, Vidakovic R, Francone M, Ilnicka-Suckiel M, Plank F, Knuuti J, Faria R, Schröder S, Berry C, Saba L, Ruzsics B, Rieckmann N, Kubiak C, Hansen KS, Müller-Nordhorn J, Szilveszter B, Sigvardsen PE, Benedek I, Orr C, Valente FX, Zvaigzne L, Suchánek V, Jankauskas A, Adic F, Woinke M, Hensey M, Lecumberri I, Thwaite E, Laule M, Kruk M, Neskovic AN, Mancone M, Kusmierz D, Pietilä M, Ribeiro VG, Drosch T, Delles C, Porcu M, Fisher M, Boussoussou M, Kragelund C, Aurelian R, Kelly S, Garcia Del Blanco B, Rubio A, Maurovich-Horvat P, Hove JD, Rodean I, Regan S, Cuellar-Calabria H, Molnár L, Larsen L, Hodas R, Napp AE, Haase R, Feger S, Mohamed M, Neumann K, Dreger H, Rief M, Wieske V, Estrella M, Martus P, Sox HC, Dewey M
- Calcium Scoring Improves Clinical Management in Patients With Low Clinical Likelihood of Coronary Artery Disease (2024)
- JACC: Cardiovascular Imaging
Brix Gitte S., Rasmussen Laust D., Rohde Palle D., Schmidt Samuel E., Nyegaard Mette, Douglas Pamela S., Newby David E., Williams Michelle C., Foldyna Borek, Knuuti Juhani, Bøttcher Morten, Winther Simon
- Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial (2024) Leikas, Aleksi J.; Hartikainen, Juha E. K.; Kastrup, Jens; Mathur, Anthony; Gyöngyösi, Mariann; Fernández-Aviles, Francisco; Sanz-Ruiz, Ricardo; Wojakowski, Wojtek; Gwizdała, Adrian; Luite, Riho; Nikkinen, Marko; Qayyum, Abbas A.; Haack-Sørensen, Mandana; Kelham, Matthew; Jones, Daniel A.; Hamzaraj, Kevin; Spannbauer, Andreas; Fernández-Santos, Maria E.; Jędrzejek, Marek; Skoczyńska, Agnieszka; Vartiainen, Niklas; Knuuti, Juhani; Saraste, Antti; Ylä-Herttuala, Seppo
- Clinical Likelihood Prediction of Hemodynamically Obstructive Coronary Artery Disease in Patients With Stable Chest Pain (2024)
- JACC: Cardiovascular Imaging
Rasmussen, Laust Dupont; Karim, Salma Raghad; Westra, Jelmer; Nissen, Louise; Dahl, Jonathan Nørtoft; Brix, Gitte Stokvad; Knuuti, Juhani; Schmidt, Samuel Emil; Holm, Niels Ramsing; Christiansen, Evald Høj; Eftekhari, Ashkan; Bøttcher, Morten; Winther, Simon
- Clinical risk prediction, coronary computed tomography angiography, and cardiovascular events in new-onset chest pain: the PROMISE and SCOT-HEART trials (2024) Rasmussen, Laust Dupont; Schmidt, Samuel Emil; Knuuti, Juhani; Vrints, Christiaan; Bøttcher, Morten; Foldyna, Borek; Williams, Michelle C.; Newby, David E.; Douglas, Pamela S.; Winther, Simon
- Comparison of thresholds for a convolutional neural network classifying medical images (2024)
- International journal of data science and analytics
Rainio, Oona; Tamminen, Jonne; Venäläinen, Mikko S.; Liedes, Joonas; Knuuti, Juhani; Kemppainen, Jukka; Klén, Riku
- Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain (2024) Biavati F, Saba L, Boussoussou M, Kofoed KF, Benedek T, Donnelly P, Rodríguez-Palomares J, Erglis A, Štěchovský C, Šakalytė G, Čemerlić Ađić N, Gutberlet M, Dodd JD, Diez I, Davis G, Zimmermann E, Kępka C, Vidakovic R, Francone M, Ilnicka-Suckiel M, Plank F, Knuuti J, Faria R, Schröder S, Berry C, Ruzsics B, Rieckmann N, Kubiak C, Hansen KS, Müller-Nordhorn J, Maurovich-Horvat P, Sigvardsen PE, Benedek I, Orr C, Valente FX, Zvaigzne L, Suchánek V, Jankauskas A, Ađić F, Woinke M, Cadogan D, Lecumberri I, Thwaite E, Kruk M, Neskovic AN, Mancone M, Kuśmierz D, Feuchtner G, Pietilä M, Ribeiro VG, Drosch T, Delles C, Cau R, Fisher M, Merkely B, Kragelund C, Aurelian R, Kelly S, García Del Blanco B, Rubio A, Szilveszter B, Hove JD, Rodean I, Regan S, Cuéllar Calabria H, Édes IF, Larsen L, Hodas R, Napp AE, Haase R, Feger S, Mohamed M, Serna-Higuita LM, Neumann K, Dreger H, Rief M, Wieske V, Budoff MJ, Estrella M, Martus P, Bosserdt M, Dewey M, DISCHARGE Trial Group
- Daily standing time, dietary fiber, and intake of unsaturated fatty acids are beneficially associated with hepatic insulin sensitivity in adults with metabolic syndrome (2024)
- Frontiers in Endocrinology
Laine, Saara; Sjöros, Tanja; Garthwaite, Taru; Honka, Miikka-Juhani; Löyttyniemi, Eliisa; Eskola, Olli; Saarenhovi, Maria; Kallio, Petri; Koivumäki, Mikko; Vähä-Ypyä, Henri; Sievänen, Harri; Vasankari, Tommi; Hirvonen, Jussi; Laitinen, Kirsi; Houttu, Noora; Kalliokoski, Kari; Saunavaara, Virva; Knuuti, Juhani; Heinonen, Ilkka H.A.
- Determining Hemodynamically Significant Coronary Artery Disease : Patient-Specific Cutoffs in Quantitative Myocardial Blood Flow Using [15O]H2O PET Imaging (2024)
- Journal of Nuclear Medicine
Roel Hoek, Pepijn A. van Diemen, Pieter G. Raijmakers, Roel S. Driessen, Yvemarie B.O. Somsen, Ruben W. de Winter, Ruurt A. Jukema, Jos W.R. Twisk, Lourens F.H.J. Robbers, Pim van der Harst, Antti Saraste, Mark Lubberink, Jens Sörensen, Paul Knaapen, Juhani Knuuti, Ibrahim Danad
- Diagnostic Performance of Quantitative Perfusion Cardiac Magnetic Resonance Imaging in Patients with Prior Coronary Artery Disease (2024)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Hoek, R; Borodzicz-Jazdzyk, S; van Diemen, PA; Somsen, YBO; de Winter, RW; Jukema, RA; Twisk, JWR; Raijmakers, PG; Knuuti, J, Maaniitty, T; Underwood, SR; Nagel, E; Robbers, LFHJ; Demirkiran, A; von Bartheld, MB; Driessen, RS; Danad, I; Götte, MJW; Knaapen, P
- Effect of Body Mass Index on Effectiveness of CT versus Invasive Coronary Angiography in Stable Chest Pain: The DISCHARGE Trial (2024) Sykes R, Collison D, Merkely B, Kofoed KF, Donnelly P, Rodríguez-Palomares J, Erglis A, Veselka J, Šakalytė G, Ađić NČ, Gutberlet M, Dodd JD, Diez I, Davis G, Zimmermann E, Kępka C, Vidakovic R, Francone M, Ilnicka-Suckiel M, Plank F, Knuuti J, Faria R, Schröder S, Berry C, Saba L, Ruzsics B, Rieckmann N, Kubiak C, Hansen KS, Müller-Nordhorn J, Maurovich-Horvat P, Knudsen AD, Benedek I, Orr C, Valente FX, Zvaigzne L, Horváth M, Jankauskas A, Ađić F, Woinke M, Keane S, Lecumberri I, Thwaite E, Laule M, Kruk M, Zivanic A, Mancone M, Kuśmierz D, Feuchtner G, Pietilä M, Ribeiro VG, Drosch T, Delles C, Porcu M, Fisher M, Bárány T, Sørum C, Aurelian R, Kelly S, Garcia Del Blanco B, Rubio A, Szilveszter B, Abdulla J, Rodean I, Regan S, Cuéllar Calabria H, Vecsey-Nagy M, Jurlander B, Hodas R, Feger S, Mohamed M, Serna-Higuita LM, Neumann K, Dreger H, Rief M, Wieske V, Ferencik M, Estrella M, Bosserdt M, Martus P, Benedek T, Dewey M, DISCHARGE Trial Group
- Effects of reduced sedentary time on resting, exercise and post-exercise blood pressure in inactive adults with metabolic syndrome – a six-month exploratory RCT (2024)
- Journal of Human Hypertension
Norha Jooa, Sjöros Tanja, Garthwaite Taru, Laine Saara, Saarenhovi Maria, Kallio Petri, Laitinen Kirsi, Houttu Noora, Vähä-Ypyä Henri, Sievänen Harri, Löyttyniemi Eliisa, Vasankari Tommi, Knuuti Juhani, Kalliokoski Kari K., Heinonen Ilkka H. A.
- Evaluation of 18F FOL a PET tracer targeting folate receptor beta in a rat model of myocardial infarction (2024) Iqbal I; Liljenback H L; Andriana P A; Stahle M S; Virta J V; Herre E A H; Miner M W M; Anand A A; Kyto V K; Li X G L; Low P S L; Srinivasarao M S; Knuuti J K; Roivainen A R; Saraste A S
- Explainable deep-learning-based ischemia detection using hybrid O-15 H2O perfusion positron emission tomography and computed tomography imaging with clinical data (2024)
- Journal of Nuclear Cardiology
Teuho, Jarmo; Schultz, Jussi; Klén, Riku; Juarez-Orozco, Luis Eduardo; Knuuti, Juhani; Saraste, Antti; Ono, Naoaki; Kanaya, Shigehiko
- Imaging of Myocardial αvβ3Integrin Expression for Evaluation of Myocardial Injury After Acute Myocardial Infarction (2024)
- Journal of Nuclear Medicine
Wail Nammas, Christian Paunonen, Jarmo Teuho, Reetta Siekkinen, Pauliina Luoto, Meeri Käkelä, Ari Hietanen, Tapio Viljanen, Matthieu Dietz, John O. Prior, Xiang-Guo Li, Anne Roivainen, Juhani Knuuti, Antti Saraste
- Impact of Absolute Myocardial Blood Flow Quantification on the Diagnostic Performance of PET-Based Perfusion Scans Using 82Rubidium (2024)
- Circulation: Cardiovascular Imaging
Rasmussen, Laust Dupont; Gormsen, Lars Christian; Ejlersen, June Anita; Karim, Salma Raghad; Westra, Jelmer; Knudsen, Lars Lyhne; Kirk, Jane; Søndergaard, Hanne Maare; Mortensen, Jesper; Knuuti, Juhani; Christiansen, Evald H.; Eftekhari, Ashkan; Bøttcher, Morten; Winther, Simon
- Location-specific prognostic significance of plaque burden, stenosis, and plaque morphology in coronary artery disease (2024)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Jukema, Ruurt A; Maaniitty, Teemu; Nurmohamed, Nick S; Raijmakers, Pieter G; Planken, R Nils; Twisk, Jos; van der Harst, Pim; Cramer, Maarten J; Min, James K; Earls, James P; Knaapen, Paul; Saraste, Antti; Knuuti, Juhani; Danad, Ibrahim
- Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart (2024) Järveläinen, Niko; Halonen, Paavo J.; Nurro, Jussi; Kuivanen, Antti; Pajula, Juho; Tarkia, Miikka; Grönman, Maria; Saraste, Antti; Laakkonen, Johanna; Toivanen, Pyry; Nieminen, Tiina; Rissanen, Tuomas T.; Knuuti, Juhani; Ylä-Herttuala, Seppo
- Minkä kuvantamistutkimuksen valitsen sepelvaltimotaudin toteamiseksi? (2024) Saraste, Antti; Maaniitty, Teemu; Knuuti, Juhani
