Juhani Knuuti
MD, professor, Turku PET Centre
Cardiovascular diseases, imaging
Juhani Knuuti’s research has focused on the physiology and pathophysiology, diagnosis and new therapies of coronary artery disease, heart failure and metabolic diseases. The research is also focused on developing and utilizing novel noninvasive imaging methods (PET, SPECT, echocardiography, MRI and CT) that will help to determine the risk and severity of CHD and heart failure and provide guidance for therapy decisions. The recent focus in cardiac research has been on vulnerable plaques, cardiac remodelling and multimodality and hybrid imaging. In metabolic and diabetes research, the focus has been in the interactions between different organs and heart in the pathogenesis and development of the cardiac diseases.
- 2018 ESC/ESH Guidelines for the management of arterial hypertension = Wytyczne ESC/ESH dotyczące postępowania
w nadciśnieniu tętniczym (2018) (2019) Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I, Windecker S, Agewall S, Barbato E, Bueno H, Collet JP, Coman IM, Dean V, Delgado V, Fitzsimons D, Gaemperli O, Hindricks G, Iung B, Juni P, Katus HA, Knuuti J, Lancellotti P, Leclercq C, McDonagh TA, Piepoli MF, Ponikowski P, Richter DJ, Roffi M, Simpson IA, Sousa-Uva M, Zamorano JL, Lurbe E, Bochud M, Jelakovic B, Januszewicz A, Polonia J, van de Borne P, Borghi C, Parati G, Manolis A, Lovic D
- 68Ga-DOTA chelate, a novel imaging agent for assessment of myocardial perfusion and infarction detection in a rodent model (2019)
- Journal of Nuclear Cardiology
Anu Autio, Sauli Uotila, Max Kiugel, Ville Kytö, Heidi Liljenbäck, Nobuyuki Kudomi, Vesa Oikonen, Olli Metsälä, Semi Helin, Juhani Knuuti, Antti Saraste, Anne Roivainen
- Absolute Stress Myocardial Blood Flow After Coronary CT Angiography Guides Referral to Invasive Angiography (2019)
- JACC: Cardiovascular Imaging
Iida Stenström, Teemu Maaniitty, Valtteri Uusitalo, Heikki Ukkonen, Sami Kajander, Maija Mäki, Wail Nammas, Jeroen J. Bax, Juhani Knuuti, Antti Saraste
- Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques (2019) Sanna Hellberg, Johanna M.U. Silvola, Heidi Liljenbäck, Max Kiugel, Olli Eskola, Harri Hakovirta, Sohvi Hörkkö, Veronique Morisson-Iveson, Ella Hirani , Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Antti Saraste, Anne Roivainen
- Anatomical and functional coronary imaging to predict long-term outcome in patients with suspected coronary artery disease: the EVINCI-outcome study (2019)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Neglia D, Liga R, Caselli C, Carpeggiani C, Lorenzoni V, Sicari R, Lombardi M, Gaemperli O, Kaufmann PA, Scholte AJHA, Underwood SR, Knuuti J, Knuuti J; for the EVINCI Study Investigators
- A primer in artificial intelligence in cardiovascular medicine (2019)
- Netherlands Heart Journal
J. W. Benjamins, T. Hendriks, J. Knuuti, L. E. Juarez-Orozco, P. van der Harst
- Big Pharma tahdittaa sairaaloiden tutkimustoimintaa? (2019) Juhani Knuuti
- Cardiac troponin elevations in marathon runners. Role of coronary atherosclerosis and skeletal muscle injury. The MaraCat Study (2019)
- International Journal of Cardiology
Paana T., Jaakkola S., Bamberg K., Saraste A., Tuunainen E., Wittfooth S., Kallio P., Heinonen O.J., Knuuti J., Pettersson K., Airaksinen K.E.J.
- Characterization of functionally significant coronary artery disease by a coronary computed tomography angiography-based index: a comparison with positron emission tomography (2019)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Constantinos D. Anagnostopoulos, Panagiotis K. Siogkas, Riccardo Liga, Georgios Benetos, Teemu Maaniitty, Antonis I. Sakellarios, Iosif Koutagiar, Ioannis Karakitsios, Michail I. Papafaklis, Valentina Berti, Roberto Sciagra, Arthur J.H.A. Scholte, Lampros K. Michalis, Oliver Gaemperli, Philipp A. Kaufmann, Gualtiero Pelosi, Oberdan Parodi,
Juhani Knuuti, Dimitrios I. Fotiadis, Danilo Neglia
- Comparison of Coronary Computed Tomography Angiography, Fractional Flow Reserve, and Perfusion Imaging for Ischemia Diagnosis (2019)
- Journal of the American College of Cardiology
Roel S. Driessen, Ibrahim Danad, Wijnand J. Stuijfzand, Pieter G. Raijmakers, Stefan P. Schumacher, Pepijn A. van Diemen, Jonathon A. Leipsic, Juhani Knuuti, Richard Underwood, Peter M. van de Ven, Albert C. van Rossum, Charles A. Taylor, Paul Knaapen
- Conclusions and recommendations (2019) The ESC Textbook of Cardiovascular Medicine Knuuti J, Saraste A
- Coronary calcium and mortality: Expanding the range of fatal outcomes (2019)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Luis Eduardo Juarez-Orozco, Juhani Knuuti
- Correction to: Cost‑effectiveness analysis of stand‑alone or combined non‑invasive imaging tests for the diagnosis of stable coronary artery disease: results from the EVINCI study (The European Journal of Health Economics, (2019), 20, 9, (1437-1449), 10.1007/s10198-019-01096-5) (2019)
- European Journal of Health Economics
Lorenzoni V., Bellelli S., Caselli C., Knuuti J., Underwood S.R., Neglia D., Turchetti G., Pietila M., Mäki M., Teresinska A., Aguadé-Bruix S., Pizzi M.N., Todiere G., Gimelli A., Lombardi M., Puzzuoli S., Mangione M., Marcheschi P., Schroeder S., Drosch T., Poddighe R., Casolo G., Anagnostopoulos C., Pugliese F., Rouzet F., Le Guludec D., Cappelli F., Valente S., Gensini G.F., Zawaideh C., Capitanio S., Sambuceti G., Marsico F., Filardi P.P., Fernández-Golfín C., Rincón L.M., Zamorano J.L., Graner F.P., Nekolla S., de Graaf M.A., Scholte A.J.H.A., Fiechter M., Stehli J., Gaemperli O., Kaufmann P.A., Reyes E., Nkomo S., Carpeggiani C., Giannessi D., Mariani F., Marinelli M., Sicari R.
- Cost-effectiveness analysis of stand-alone or combined non-invasive imaging tests for the diagnosis of stable coronary artery disease: results from the EVINCI study (2019)
- European Journal of Health Economics
Lorenzoni V., Bellelli S., Caselli C., Knuuti J., Underwood S.R., Neglia D., Turchetti G., Pietila M., Mäki M., Teresinska A., Aguadé-Bruix S., Pizzi M.N., Todiere G., Gimelli A., Lombardi M., Puzzuoli S., Mangione M., Marcheschi P., Schroeder S., Drosch T., Poddighe R., Casolo G., Anagnostopoulos C., Pugliese F., Rouzet F., Le Guludec D., Cappelli F., Valente S., Gensini G.F., Zawaideh C., Capitanio S., Sambuceti G., Marsico F., Filardi P.P., Fernández-Golfín C., Rincón L.M., Zamorano J.L., Graner F.P., Nekolla S., de Graaf M.A., Scholte A.J.H.A., Fiechter M., Stehli J., Gaemperli O., Kaufmann P.A., Reyes E., Nkomo S., Carpeggiani C., Giannessi D., Mariani F., Marinelli M., Sicari R.; For the EVINCI Investigators
- CTCA based assessment of endothelial shear stress and functional significance of coronary lesions: relationship and comparative performance in predicting impaired vasodilating capability by PET myocardial perfusion imaging (2019)
- European Journal of Nuclear Medicine and Molecular Imaging
Kalykakis GE, Antonopoulos A, Pitsargiotis T, Kafouris P, Siogkas P, Giannopoulos A, Liga R, Kaufmann P, Scolte A, Pelosi G, Parodi O, Knuuti J, Neglia D, Fotiadis D, Anagnostopoulos C
- Data on the impact of scan quality on the diagnostic performance of CCTA, SPECT, and PET for diagnosing myocardial ischemia defined by fractional flow reserve on a per vessel level (2019) P.A. van Diemen, R.S. Driessen, W.J. Stuijfzand, P.G. Raijmakers, S.P. Schumacher, M.J. Bom, H. Everaars, J.K. Min, J.A. Leipsic, J. Knuuti, S.R. Underwood, P.M. van de Ven, A.C. van Rossum, I. Danad, P. Knaapen
- Determinants of Myocardial Strain in Experimental Chronic Myocardial Infarction (2019)
- Ultrasound in Medicine and Biology
Haitham Ballo, Miikka Tarkia, Matti Haavisto, Christoffer Stark, Marjatta Strandberg, Tommi Vähäsilta, Virva Saunavaara, Tuula Tolvanen, Ville-Veikko Hynninen, Timo Savunen, Anne Roivainen, Juhani Knuuti, Antti Saraste
- Detox-tuotteesta maksavaurio - seurauksena parjausta ja salaliittoväitteitä (2019) Juhani Knuuti
- Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data (2019) Haase R, Schlattmann P, Gueret P, Andreini D, Pontone G, Alkadhi H, Hausleiter J, Garcia MJ, Leschka S, Meijboom WB, Zimmermann E, Gerber B, Schoepf UJ, Shabestari AA, Norgaard BL, Meijs MFL, Sato A, Ovrehus KA, Diederichsen ACP, Jenkins SMM, Knuuti J, Hamdan A, Halvorsen BA, Mendoza-Rodriguez V, Rochitte CE, Rixe J, Wan YL, Langer C, Bettencourt N, Martuscelli E, Ghostine S, Buechel RR, Nikolaou K, Mickley H, Yang L, Zhang ZQ, Chen MY, Halon DA, Rief M, Sun K, Hirt-Moch B, Niinuma H, Marcus RP, Muraglia S, Jakamy R, Chow BJ, Kaufmann PA, Tardif JC, Nomura C, Kofoed KF, Laissy JP, Arbab-Zadeh A, Kitagawa K, Laham R, Jinzaki M, Hoe J, Rybicki FJ, Scholte A, Paul N, Tan SY, Yoshioka K, Rohle R, Schuetz GM, Schueler S, Coenen MH, Wieske V, Achenbach S, Budoff MJ, Laule M, Newby DE, Dewey M
- Diagnostic value of longitudinal flow gradient for the presence of haemodynamically significant coronary artery disease (2019)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Bom MJ, Driessen RS, Raijmakers PG, Everaars H, Lammertsma AA, van Rossum AC, van Royen N, Knuuti J, Mäki M, Danad I, Knaapen P
