Harri Niinikoski
Professor, Nutrition in Medicine (Institute of Biomedicine)
Asiantuntijuusalueet
Childhood endocrinology and nutrition; inherited metabolic diseases; neonatal screening; prevention of cardiovascular risk factors.
Biografia
Professor Harri Niinikoski graduated from the Medical School at the University of Turku
in 1991, where he also specialized in Pediatrics in 2000 and received
subspecialty in Pediatric Endocrinology in 2006. He defended his thesis on prevention
of cardiovascular risk factors in childhood in 1997 (The STRIP study). He did
his post-doc training at the Childhood Nutrition Research Center at the Baylor
School of Medicine, Houston, Texas, in 2001-2003. Subsequently, he worked as a
Senior Clinical Researcher and Clinical Lecturer at the Department of Pediatrics,
University of Turku, and in 2011-2015 as the Head of the Division of Pediatric
Care in Turku University Hospital. From 2015, he has been Professor of Nutrition
in Medicine
Tutkimus
Professor Harri Niinikoski’s research interest focus on primary prevention of
cardiovascular disease, and childhood nutrition, endocrinology and metabolism.
Moreover, he has been closely involved in launching the neonatal metabolic
screening program which started in Finland in 2015.
Main research projects are 1) The STRIP study (The Special Turku coronary risk
factor Intervention Project) which started in 1990 and involved 1062 infants
which were randomized into nutrition an intervention or a control group. He is deputy P.I. in STRIP; 2) DIARA2 study which involves 317 children (217 in
Turku, 100 in Oulu) whose mothers were treated with either metformin or insulin
due to gestational diabetes. The children are now thoroughly investigated at 9
years of age; 3) LPI study. Lysinuric protein intolerance (LPI) is a rare
metabolic disease which belongs to the Finnish disease heritage. There are
approx. 50 Finnish patients who are annually studied at the Turku University
Hospital pediatric metabolic outpatient clinic; 4) Congenital
hypothyroidism study. CH has been screened in Finland since 1980, affects
1:2000 newborns and is treated with thyroxine. The outcome of the treatment of
CH is investigated in national CH study which is launched in 2018.
Opetus
In 2006-2010, Harri Niinikoski worked as a full-time teacher of pediatrics at the
Department of Pediatrics, University of Turku.
Julkaisut
- Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty (2014) Cousminer DL, Stergiakouli E, Berry DJ, Ang W, Groen-Blokhuis MM, Korner A, Siitonen N, Ntalla I, Marinelli M, Perry JRB, Kettunen J, Jansen R, Surakka I, Timpson NJ, Ring S, Mcmahon G, Power C, Wang C, Kahonen M, Viikari J, Lehtimaki T, Middeldorp CM, Pol HEH, Neef M, Weise S, Pahkala K, Niinikoski H, Zeggini E, Panoutsopoulou K, Bustamante M, Penninx BWJH, Murabito J, Torrent M, Dedoussis GV, Kiess W, Boomsma DI, Pennell CE, Raitakari OT, Hypponen E, Smith GD, Ripatti S, McCarthy MI, Widen E
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children. (2014)
- American Journal of Clinical Nutrition
Ahola-Olli AV, Pitkänen N, Kettunen J, Oikonen MK, Mikkilä V, Lehtimäki T, Kähönen M, Pahkala K, Niinikoski H, Kangas AJ, Soininen P, Ala-Korpela M, Viikari JS, Rönnemaa T, Simell O, Raitakari OT
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Maternal overweight impacts infant feeding patterns - the STEPS Study (2014)
- European Journal of Clinical NutritionCurrent Cardiovascular Risk Reports
Mäkelä Johanna, Vaarno Jenni, Kaljonen Anne, Niinikoski Harri, Lagström Hanna
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarcheAssociation of Fitness With Vascular Intima-Media Thickness and Elasticity in Adolescence (2014) Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, Albrecht E, Ang WQ, Corre T, Cousminer DL, Feenstra B, Franceschini N, Ganna A, Johnson AD, Kjellqvist S, Lunetta KL, McMahon G, Nolte IM, Paternoster L, Porcu E, Smith AV, Stolk L, Teumer A, Tšernikova N, Tikkanen E, Ulivi S, Wagner EK, Amin N, Bierut LJ, Byrne EM, Hottenga JJ, Koller DL, Mangino M, Pers TH, Yerges-Armstrong LM, Hua Zhao J, Andrulis IL, Anton-Culver H, Atsma F, Bandinelli S, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Bolla MK, Bonanni B, Brauch H, Brenner H, Buring JE, Chang-Claude J, Chanock S, Chen J, Chenevix-Trench G, Collée JM, Couch FJ, Couper D, Coviello AD, Cox A, Czene K, D'adamo AP, Davey Smith G, De Vivo I, Demerath EW, Dennis J, Devilee P, Dieffenbach AK, Dunning AM, Eiriksdottir G, Eriksson JG, Fasching PA, Ferrucci L, Flesch-Janys D, Flyger H, Foroud T, Franke L, Garcia ME, García-Closas M, Geller F, de Geus EE, Giles GG, Gudbjartsson DF, Gudnason V, Guénel P, Guo S, Hall P, Hamann U, Haring R, Hartman CA, Heath AC, Hofman A, Hooning MJ, Hopper JL, Hu FB, Hunter DJ, Karasik D, Kiel DP, Knight JA, Kosma VM, Kutalik Z, Lai S, Lambrechts D, Lindblom A, Mägi R, Magnusson PK, Mannermaa A, Martin NG, Masson G, McArdle PF, McArdle WL, Melbye M, Michailidou K, Mihailov E, Milani L, Milne RL, Nevanlinna H, Neven P, Nohr EA, Oldehinkel AJ, Oostra BA, Palotie A, Peacock M, Pedersen NL, Peterlongo P, Peto J, Pharoah PD, Postma DS, Pouta A, Pylkäs K, Radice P, Ring S, Rivadeneira F, Robino A, Rose LM, Rudolph A, Salomaa V, Sanna S, Schlessinger D, Schmidt MK, Southey MC, Sovio U, Stampfer MJ, Stöckl D, Storniolo AM, Timpson NJ, Tyrer J, Visser JA, Vollenweider P, Völzke H, Waeber G, Waldenberger M, Wallaschofski H, Wang Q, Willemsen G, Winqvist R, Wolffenbuttel BH, Wright MJ; Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines Cohort Study; InterAct Consortium; Early Growth Genetics (EGG) Consortium, Boomsma DI, Econs MJ, Khaw KT, Loos RJ, McCarthy MI, Montgomery GW, Rice JP, Streeten EA, Thorsteinsdottir U, van Duijn CM, Alizadeh BZ, Bergmann S, Boerwinkle E, Boyd HA, Crisponi L, Gasparini P, Gieger C, Harris TB, Ingelsson E, Järvelin MR, Kraft P, Lawlor D, Metspalu A, Pennell CE, Ridker PM, Snieder H, Sørensen TI, Spector TD, Strachan DP, Uitterlinden AG, Wareham NJ, Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK, Cousminer DL, Stergiakouli E, Berry DJ, Ang W, Groen-Blokhuis MM, Körner A, Siitonen N, Ntalla I, Marinelli M, Perry JR, Kettunen J, Jansen R, Surakka I, Timpson NJ, Ring S, McMahon G, Power C, Wang C, Kähönen M, Viikari J, Lehtimäki T, Middeldorp CM, Hulshoff Pol HE, Neef M, Weise S, Pahkala K, Niinikoski H, Zeggini E, Panoutsopoulou K, Bustamante M, Penninx BW, Murabito J, Torrent M, Dedoussis GV, Kiess W, Boomsma DI, Pennell CE, Raitakari OT, Hyppönen E, Davey Smith G, Ripatti S, McCarthy MI, Widén E, Alizadeh BZ, de Boer RA, Boezen HM, Bruinenberg M, Franke L, van der Harst P, Hillege HL, van der Klauw MM, Navis G, Ormel J, Postma D, Rosmalen JG, Slaets JP, Snieder H, Stolk RP, Wolffenbuttel BH, Wijmenga C, Forouhi N, Kerrison ND, Langenberg C, Scott RA, Sharp SJ, Sims M, Barroso I, Deloukas P, McCarthy MI, Arriola L, Balkau B, Barricarte A, Boeing H, Franks PW, Gonzalez C, Grioni S, Kaaks R, Key TJ, Navarro C, Nilsson PM, Overvad K, Palli D, Panico S, Quirós J, Rolandsson O, Sacerdote C, Sánchez MJ, Slimani N, Tjonneland A, Tumino R, van der A DL, van der Schouw YT, Riboli E, Wareham NJ, Bowtell DD, Green A, Chenevix-Trench G, deFazio A, Gertig D, Webb PM, Brauch H, Justenhoven C, Hamann U, Ko YD, Baisch C, Fischer HP, Pesch B, Rabstein S, Spickenheuer A, Harth V, Aghmesheh M, Amor D, Andrews L, Antill Y, Armitage S, Arnold L, Balleine R, Bankier A, Bastick P, Beesley J, Beilby J, Bennett I, Bennett B, Berry G, Blackburn A, Bogwitz M, Brennan M, Brown M, Buckley M, Burgess M, Burke J, Butow P, Byron K, Callen D, Campbell I, Chauhan D, Chenevix-Trench G, Christian A, Clarke C, Colley A, Cotton D, Crook A, Cui J, Culling B, Cummings M, Dawson SJ, deFazio A, Delatycki M, Dickson R, Dixon J, Dobrovic A, Dudding T, Edkins T, Edwards S, Eisenbruch M, Farshid G, Fawcett S, Fellows A, Fenton G, Field M, Firgaira F, Flanagan J, Fleming J, Fong P, Forbes J, Fox S, French J, Friedlander M, Gaff C, Gardner M, Gattas M, George P, Giles G, Gill G, Goldblatt J, Greening S, Grist S, Eric H, Hardie K, Harris M, Hart S, Hayward N, Healey S, Heiniger L, Hopper J, Humphrey E, Hunt C, James P, Jenkins M, Jones A, Kefford R, Kidd A, Kiely B, Kirk J, Koehler J, Kollias J, Kovalenko S, Lakhani S, Leaming A, Leary J, Lim J, Lindeman G, Lipton L, Lobb L, Mann G, Marsh D, McLachlan SA, Meiser B, Meldrum C, Milne R, Mitchell G, Newman B, O'Connell S, O'Loughlin I, Osborne R, Pachter N, Patterson B, Peters L, Phillips K, Price M, Purser L, Reeve J, Reeve T, Richards R, Rickard E, Robinson B, Rudzki B, Saleh M, Salisbury E, Sambrook J, Saunders C, Saunus J, Sayer R, Scott E, Scott R, Scott C, Seshadri R, Sexton A, Sharma R, Shelling A, Simpson P, Southey M, Spurdle A, Suthers G, Sykes P, Taylor D, Taylor J, Thierry B, Thompson E, Thorne H, Townshend S, Trainer A, Tran L, Tucker K, Tyler J, Visvader J, Walker L, Walpole I, Waring P, Warner B, Warren G, Williams R, Wilson J, Winship I, Wu K, Young MA
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Sydän- ja verisuonisairauksien ehkäisy lapsuudesta alkaenComparison of tandem mass spectrometric methods to human milk triacylglycerol analysis (2014) Pahkala K, Niinikoski H, Raitakari O
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)
- Tandem mass spectrometric analysis of human milk Triacylglycerols from normal weight and overweight mothers on different dietsEndothelial function in long-term survivors of childhood acute lymphoblastic leukemia: Effects of a home-based exercise program (2014) Linderborg K., Kalpio M., Mäkelä J., Niinikoski H., Kallio H., Lagström H.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- The effect of dietary intervention on paraffin-stimulated saliva and dental health of children participating in a randomized controlled trial (2014) M.A. Laine, M. Tolvanen, K. Pienihäkkinen, E. Söderling, H. Niinikoski, O. Simell, S. Karjalainen
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- The STRIP Study: Long-Term Impact of a Low Saturated Fat/Low Cholesterol Diet (2014) Niinikoski H., Pahkala K., Viikari J., Rönnemaa T., Jula A., Lagström H., Simell O., Raitakari O.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- (2013) Pahkala K, Laitinen TT, Heinonen OJ, Viikari JSA, Ronnemaa T, Niinikoski H, Helajarvi H, Juonala M, Simell O, Raitakari OT
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Infancy-Onset Dietary Counseling of Low-Saturated-Fat Diet Improves Insulin Sensitivity in Healthy Adolescents 15-20 Years of Age The Special Turku Coronary Risk Factor Intervention Project (STRIP) study (2013) EuroFoodChem XVII Kalpio Marika, Linderborg Kaisa, Mäkelä Johanna, Niinikoski Harri, Lagström Hanna, Kallio Heikki
(O2 Muu julkaisu )
- (2013)
- Pediatric Blood and Cancer
Jarvela LS, Niinikoski H, Heinonen OJ, Lahteenmaki PM, Arola M, Kemppainen J
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Ideal Cardiovascular Health in Adolescence Effect of Lifestyle Intervention and Association With Vascular Intima-Media Thickness and Elasticity (The Special Turku Coronary Risk Factor Intervention Project for Children [STRIP] Study) (2013)
- CirculationEarly Human Development
Pahkala K, Hietalampi H, Laitinen TT, Viikari JSA, Ronnemaa T, Niinikoski H, Lagstrom H, Talvia S, Jula A, Heinonen OJ, Juonala M, Simell O, Raitakari OT
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Infancy-onset dietary counseling improves insulin sensitivity in healthy adolescents. The special Turku coronary risk factor intervention project (STRIP) (2013) Oranta O, Pahkala K, Ruottinen S, Niinikoski H, Lagstrom H, Viikari JSA, Jula A, Loo BM, Ronnemaa T, Raitakari OT
(O2 Muu julkaisu )
- (2013) Oranta O, Pahkala K, Ruottinen S, Niinikoski H, Lagstrom H, Viikari JSA, Jula A, Loo BM, Simell O, Ronnemaa T, Raitakari OT
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism (2013) Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimaki T, Kreiner-Moller E, Warrington NM, Bustamante M, Feenstra B, Berry DJ, Thiering E, Pfab T, Barton SJ, Shields BM, Kerkhof M, van Leeuwen EM, Fulford AJ, Kutalik Z, Zhao JH, den Hoed M, Mahajan A, Lindi V, Goh LK, Hottenga JJ, Wu Y, Raitakari OT, Harder MN, Meirhaeghe A, Ntalla I, Salem RM, Jameson KA, Zhou KX, Monies DM, Lagou V, Kirin M, Heikkinen J, Adair LS, Alkuraya FS, Al-Odaib A, Amouyel P, Andersson EA, Bennett AJ, Blakemore AIF, Buxton JL, Dallongeville J, Das S, de Geus EJC, Estivill X, Flexeder C, Froguel P, Geller F, Godfrey KM, Gottrand F, Groves CJ, Hansen T, Hirschhorn JN, Hofman A, Hollegaard MV, Hougaard DM, Hypponen E, Inskip HM, Isaacs A, Jorgensen T, Kanaka-Gantenbein C, Kemp JP, Kiess W, Kilpelainen TO, Klopp N, Knight BA, Kuzawa CW, McMahon G, Newnham JP, Niinikoski H, Oostra BA, Pedersen L, Postma DS, Ring SM, Rivadeneira F, Robertson NR, Sebert S, Simell O, Slowinski T, Tiesler CMT, Tonjes A, Vaag A, Viikari JS, Vink JM, Vissing NH, Wareham NJ, Willemsen G, Witte DR, Zhang HT, Zhao JH, Wilson JF, Stumvoll M, Prentice AM, Meyer BF, Pearson ER, Boreham CAG, Cooper C, Gillman MW, Dedoussis GV, Moreno LA, Pedersen O, Saarinen M, Mohlke KL, Boomsma DI, Saw SM, Lakka TA, Korner A, Loos RJF, Ong KK, Vollenweider P, van Duijn CM, Koppelman GH, Hattersley AT, Holloway JW, Hocher B, Heinrich J, Power C, Melbye M, Guxens M, Pennell CE, Bonnelykke K, Bisgaard H, Eriksson JG, Widen E, Hakonarson H, Uitterlinden AG, Pouta A, Lawlor DA, Smith GD, Frayling TM, McCarthy MI, Grant SFA, Jaddoe VWV, Jarvelin MR, Timpson NJ, Prokopenko I, Freathy RM
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Response to the letter to the editor “Indices of insulin sensitivity and resistance: Adequate logarithmic transformation are needed to keep mathematical equivalence” by Tomoyuki Kawada (2013) Makela J, Lagstrom H, Kaljonen A, Simell O, Niinikoski H
(O2 Muu julkaisu )
- The relationship between milk TAG composition and mother's weight and dietEffects of a home-based exercise program on metabolic risk factors and fitness in long-term survivors of childhood acute lymphoblastic leukemia (2013)
- Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism K. Linderborg, J. Mäkelä, M. Kalpio, H. Niinikoski, H. Kallio, H. Lagström
(O2 Muu julkaisu )
- Effect of Repeated Dietary Counseling on Serum Lipoproteins From Infancy to Adulthood (2012) Niinikoski H, Pahkala K, Ala-Korpela M, Viikari J, Ronnemaa T, Lagstrom H, Jokinen E, Jula A, Savolainen MJ, Simell O, Raitakari OT
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Effects of a home-based exercise program on metabolic risk factors and fitness in long-term survivors of childhood acute lymphoblastic leukemia (2012)
- Pediatric Blood and Cancer
Järvelä Liisa S., Kemppainen Jukka, Niinikoski Harri, Hannukainen Jarna C., Lähteenmäki Päivi M., Kapanen Jukka, Arola Mikko, Heinonen Olli J.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- (2012)
- Pediatric Blood and Cancer
Jarvela LS, Kemppainen J, Niinikoski H, Hannukainen JC, Lahteenmaki PM, Kapanen J, Arola M, Heinonen OJ
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
