Markus Juonala
Professor
Areas of expertise
Internal medicine; endocrinology; cardiovascular risk
Research community or research topic
Cardiovascular epidemiology, Young Finns Study, i3c consortium
Biography
Professor Markus Juonala (MD,
PhD, University of Turku) is a specialist in internal medicine and
endocrinology at the Turku University Hospital, Turku, Finland. Since 2001, he
has been conducting research on longitudinal studies examining the importance
of childhood risk factors on later cardiovascular health. His PhD work was
based primarily on the Cardiovascular Risk in Young Finns Study (University of
Turku, April 2005). Since 2008, he has had a major involvement in the
development of the International Childhood Cardiovascular Cohort (i3C)
Consortium that combines the efforts of the main longitudinal studies
worldwide. In June 2014, he was appointed as Professor of Internal Medicine at
the University of Turku. In 2014-2015 and 2018-2019 he has been working as the Dame Elisabeth Murdoch Fellow in Murdoch Childrens Research Institute
(MCRI).
His career
publications total is 270 (h-index 44) with published highlights including a
first-author paper in the New England Journal of Medicine, the first-ranked
general medicine journal, one paper in JAMA, the third-ranked general medicine
journal and 30 papers (11 as first/last author) published in either the number
one, two, or three ranked cardiovascular disease journals (17 in Circulation,
five in the Journal of the American College of Cardiology, eight in the
European Heart Journal).
Research
Professor Juonala’s
principal research focus has been to provide novel information on the effects
of childhood risk factors on cardiovascular health in adulthood. Beginning from
the summer of 2008 he has led a research group within the Young Finns Study and
i3c consortium with special interest on cardiometabolic risk factors. The most
important findings of his research have provided information on childhood and
early adulthood risk factors for atherosclerosis, suggesting that childhood
risk factors, such as dyslipidaemia, elevated blood pressure and smoking,
predict early atherosclerosis and its progression independent of adult risk
factors levels. Concerning cardiometabolic risk factors, his group has been
able to show that overweight and metabolic syndrome diagnosed either in childhood or adulthood
is predictive of carotid atherosclerosis and its progression in adulthood.
However, at the time of obesity epidemic, the most important findings concern
the reversibility of cardiovascular risk. His work has demonstrated that although overweight and metabolic syndrome are predictive of early atherosclerosis, favourable changes
in lifestyle associated with weight maintenance or reduction improve
cardiovascular health.
Teaching
Teaching responsibilities: 1) Internal medicine for medical students, 2) Internal medicine specialisation programme for MDs
Special interest areas: Acute internal medicine, endocrinology, lipidology
Publications
- Fasting Glucose and the Risk of Depressive Symptoms: Instrumental-Variable Regression in the Cardiovascular Risk in Young Finns Study (2017)
- International Journal of Behavioral Medicine
Karolina Wesołowska, Marko Elovainio, Taina Hintsa, Markus Jokela, Laura Pulkki-Råback, Niina Pitkänen, Jari Lipsanen, Janne Tukiainen, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Markus Juonala, Olli Raitakari, Liisa Keltikangas-Järvinen
(A1 Refereed original research article in a scientific journal)
- Fasting glucose and the risk of depressive symptoms: Instrumental-variable regression in the Cardiovascular Risk in Young Finns Study (2017)
- International Journal of Behavioral Medicine
Wesołowska K, Elovainio M, Hintsa T, Jokela M, Pulkki-Råback L, Pitkänen N, Lipsanen J, Tukiainen J, Lyytikäinen LP, Lehtimäki T, Juonala M, Raitakari O, Keltikangas-Järvinen L
(A1 Refereed original research article in a scientific journal)
- Genetic loci associated with heart rate variability and their effects on cardiac disease risk (2017) Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikainen LP, Maihofer AX, Minassian A, van der Most PJ, Muller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen IE, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kahonen N, Ashar F, Ashar F, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao DP, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundstrom J, Swenne CA, Syvanen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong QN, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Jarvelin MR, Kaab S, Kahonen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimaki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC
(A1 Refereed original research article in a scientific journal)
- Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits (2017) Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, Ngwa JS, Ahluwalia TS, Chu AY, Heard-Costa NL, Lim E, Perez J, Eicher JD, Kutalik Z, Xue L, Mahajan A, Renstrom F, Wu J, Qi QB, Ahmad S, Alfred T, Amin N, Bielak LF, Bonnefond A, Bragg J, Cadby G, Chittani M, Coggeshall S, Corre T, Direk N, Eriksson J, Fischer K, Gorski M, Harder MN, Horikoshi M, Huang T, Huffman JE, Jackson AU, Justesen JM, Kanoni S, Kinnunen L, Kleber ME, Komulainen P, Kumari M, Lim U, Luan J, Lyytikainen LP, Mangino M, Manichaikul A, Marten J, Middelberg RPS, Mueller-Nurasyid M, Navarro P, Perusse L, Pervjakova N, Sarti C, Smith AV, Smith JA, Stancakova A, Strawbridge RJ, Stringham HM, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van der Most PJ, Van Vliet-Ostaptchouk JV, Vedantam SL, Verweij N, Vink JM, Vitart V, Wu Y, Yengo L, Zhang WH, Zhao JH, Zimmermann ME, Zubair N, Abecasis GR, Adair LS, Afaq S, Afzal U, Bakker SJL, Bartz TM, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Braga D, Buckley BM, Buyske S, Campbell H, Chambers JC, Collins FS, Curran JE, de Borst GJ, de Craen AJM, de Geus EJC, Dedoussis G, Delgado GE, den Ruijter HM, Eiriksdottir G, Eriksson AL, Esko T, Faul JD, Ford I, Forrester T, Gertow K, Gigante B, Glorioso N, Gong J, Grallert H, Grammer TB, Grarup N, Haitjema S, Hallmans G, Hamsten A, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie ND, Heath AC, Hernandez D, Hindorff L, Hocking LJ, Hollensted M, Holmen OL, Homuth G, Hottenga JJ, Huang J, Hung J, Hutri-Kahonen N, Ingelsson E, James AL, Jansson JO, Jarvelin MR, Jhun MA, Jorgensen ME, Juonala M, Kahonen M, Karlsson M, Koistinen HA, Kolcic I, Kolovou G, Kooperberg C, Kramer BK, Kuusisto J, Kvaloy K, Lakka TA, Langenberg C, Launer LJ, Leander K, Lee NR, Lind L, Lindgren CM, Linneberg A, Lobbens S, Loh M, Lorentzon M, Luben R, Lubke G, Ludolph-Donislawski A, Lupoli S, Madden PAF, Mannikko R, Marques-Vidal P, Martin NG, McKenzie CA, McKnight B, Mellstrom D, Menni C, Montgomery GW, Musk AW, Narisu N, Nauck M, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Peyser PA, Pisinger C, Porteous DJ, Raitakari OT, Rankinen T, Rao DC, Rasmussen-Torvik LJ, Rawal R, Rice T, Ridker PM, Rose LM, Bien SA, Rudan I, Sanna S, Sarzynski MA, Sattar N, Savonen K, Schlessinger D, Scholtens S, Schurmann C, Scott RA, Sennblad B, Siemelink MA, Silbernagel G, Slagboom PE, Snieder H, Staessen JA, Stott DJ, Swertz MA, Swift AJ, Taylor KD, Tayo BO, Thorand B, Thuillier D, Tuomilehto J, Uitterlinden AG, Vandenput L, Vohl MC, Volzke H, Vonk JM, Waeber G, Waldenberger M, Westendorp RGJ, Wild S, Willemsen G, Wolffenbuttel BHR, Wong A, Wright AF, Zhao W, Zillikens MC, Baldassarre D, Balkau B, Bandinelli S, Boger CA, Boomsma DI, Bouchard C, Bruinenberg M, Chasman DI, Chen YDI, Chines PS, Cooper RS, Cucca F, Cusi D, de Faire U, Ferrucci L, Franks PW, Froguel P, Gordon-Larsen P, Grabe HJ, Gudnason V, Haiman CA, Hayward C, Hveem K, Johnson AD, Jukema W, Kardia SLR, Kivimaki M, Kooner JS, Kuh D, Laakso M, Lehtimaki T, Le Marchand L, Marz W, McCarthy MI, Metspalu A, Morris AP, Ohlsson C, Palmer LJ, Pasterkamp G, Pedersen O, Peters A, Peters U, Polasek O, Psaty BM, Qi L, Rauramaa R, Smith BH, Sorensen TIA, Strauch K, Tiemeier H, Tremoli E, Van der Harst P, Vestergaard H, Vollenweider P, Wareham NJ, Weir DR, Whitfield JB, Wilson JF, Tyrrell J, Frayling TM, Barroso I, Boehnke M, Deloukas P, Fox CS, Hirschhorn JN, Hunter DJ, Spector TD, Strachan DP, van Duijn CM, Heid IM, Mohlke KL, Marchini J, Loos RJF, Kilpelainen TO, Liu CT, Borecki IB, North KE, Cupples LA, Hunter DJ, Hirschhorn JN, Strachan DP, Spector TD, Heid IM, van Duijn CM, Marchini J, Mohlke KL, Kilpelainen TO, Loos RJF, Borecki IB, Liu CT, Cupples LA, North KE
(A1 Refereed original research article in a scientific journal)
- Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults (2017) Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue LT, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi QB, Ngwa JS, Renström F, Quaye L, Eicher JD, Hayes JE, Cornelis M, Kutalik Z, Lim E, Luan J, Huffman JE, Zhang WH, Zhao W, Griffin PJ, Haller T, Ahmad S, Marques-Vidal PM, Bien S, Yengo L, Teumer A, Smith AV, Kumari M, Harder MN, Justesen JM, Kleber ME, Hollensted M, Lohman K, Rivera NV, Whitfield JB, Zhao JH, Stringham HM, Lyytikäinen LP, Huppertz C, Willemsen G, Peyrot WJ, Wu Y, Kristiansson K, Demirkan A, Fornage M, Hassinen M, Bielak LF, Cadby G, Tanaka T, Magl R, Van der Most PJ, Jackson AU, Bragg-Gresham JL, Vitart V, Marten J, Navarro P, Bellis C, Pasko D, Johansson A, Snitker S, Cheng YC, Eriksson J, Lim U, Aadahl M, Adair LS, Amin N, Balkau B, Auvinen J, Beilby J, Bergman RN, Bergmann S, Bertoni AG, Blangero J, Bonnefond A, Bonnycastle LL, Borja JB, Brage S, Busonero F, Buyske S, Campbell H, Chines PS, Collins FS, Corre T, Smith GD, Delgado GE, Dueker N, Dorr M, Ebeling T, Eiriksdottir G, Esko T, Faul JD, Fu M, Faerch K, Gieger C, Glaser S, Gong J, Gordon-Larsen P, Grallert H, Grammer TB, Grarup N, van Grootheest G, Harald K, Hastie ND, Havulinna AS, Hernandez D, Hindorff L, Hocking LJ, Holmens OL, Holzapfel C, Hottenga JJ, Huang J, Huang T, Hui J, Huth C, Hutri-Kähönen N, James AL, Jansson JO, Jhun MA, Juonala M, Kinnunen L, Koistinen HA, Kolcic I, Komulainen P, Kuusisto J, Kvaløy K, Kähönen M, Lakka TA, Launer LJ, Lehne B, Lindgren CM, Lorentzon M, Luben R, Marre M, Milaneschi Y, Monda KL, Montgomery GW, De Moor MHM, Mulas A, Müller-Nurasyid M, Musk AW, Männikkö R, Männistö S, Narisu N, Nauck M, Nettleton JA, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Paternoster L, Perez J, Perola M, Peters A, Peters U, Peyser PA, Prokopenko I, Puolijoki H, Raitakari OT, Rankinen T, Rasmussen-Torvik LJ, Rawal R, Ridker PM, Rose LM, Rudan I, Sarti C, Sarzynski MA, Savonen K, Scott WR, Sanna S, Shuldiner AR, Sidney S, Silbernagel G, Smith BH, Smith JA, Snieder H, Stančáková A, Sternfeld B, Swift AJ, Tammelin T, Tan ST, Thorand B, Thuillier D, Vandenput L, Vestergaard H, van Vliet-Ostaptchouk JV, Vohl MC, Völker U, Waeber G, Walker M, Wild S, Wong A, Wright AF, Zillikens MC, Zubair N, Haiman CA, Lemarchand L, Gyllensten U, Ohlsson C, Ohlsson C, Hofman A, Rivadeneira F, Uitterlinden AG, Pérusse L, Wilson JF, Hayward C, Polasek O, Cucca F, Hveem K, Hartman CA, Tönjes A, Bandinelli S, Palmer LJ, Kardia SLR, Rauramaa R, Sørensen TIA, Tuomilehto J, Salomaa V, Penninx BWJH, de Geus EJC, Boomsma DI, Lehtimaki T, Mangino M, Laakso M, Bouchard C, Martin NG, Kuh D, Liu YM, Linneberg A, Marz W, Strauch K, Kivimäki M, Harris TB, Gudnason V, Völzke H, Qi L, Järvelin MR, Chambers JC, Kooner JS, Froguel P, Kooperberg C, Vollenweider P, Hallmans G, Hansen T, Pedersen O, Metspalu A, Wareham NJ, Langenberg C, Weir DR, Porteous DJ, Boerwinkle E, Chasman DI, Abecasis GR, Barroso I, McCarthy MI, Frayling TM, O'Connell JR, van Duijn CM, Boehnke M, Heid IM, Mohlke KL, Strachan DP, Fox CS, Liu CT, Hirschhorn JN, Klein RJ, Johnson AD, Borecki IB, Franks PW, North KE, Cupples LA, Loos RJF, Kilpeläinen TO, Klein RJ, Hirschhorn JN, Liu CT, Fox CS, North KE, Franks PW, Borecki IB, Johnson AD, Kilpeläinen TO, Loos RJF, Cupples LA, Mohlke KL, Strachan DP
(A1 Refereed original research article in a scientific journal)
- Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS) (2017)
- International Journal of Cardiology
Laitinen TT, Ruohonen S, Juonala M, Magnussen CG, Mikkila V, Mikola H, Hutri-Kahonen N, Laitinen T, Tossavainen P, Jokinen E, Niinikoski H, Jula A, Viikari JSA, Ronnemaa T, Raitakari OT, Pahkala K
(A1 Refereed original research article in a scientific journal)
- Influence of Child and Adult Elevated Blood Pressure on Adult Arterial Stiffness The Cardiovascular Risk in Young Finns Study (2017) Aatola H, Koivistoinen T, Tuominen H, Juonala M, Lehtimaki T, Viikari JSA, Raitakari OT, Kahonen M, Hutri-Kahonen N
(A1 Refereed original research article in a scientific journal)
- Intergenerational Continuity in Qualities of the Parent-Child Relationship: Mediating and Moderating Mechanisms (2017)
- Journal of Child and Family Studies
Savelieva K, Pulkki-Raback L, Jokela M, Hintsanen M, Merjonen P, Hutri-Kahonen N, Juonala M, Viikari J, Raitakari O, Keltikangas-Jarvinen L
(A1 Refereed original research article in a scientific journal)
- Intergenerational transmission of socioeconomic position and ideal cardiovascular health: 32-year follow-up study (2017) Savelieva K, Pulkki-Råback L, Jokela M, Kubzansky LD, Elovainio M, Mikkilä V, Tammelin T, Juonala M, Raitakari OT, Keltikangas-Järvinen L.
(A1 Refereed original research article in a scientific journal)
- Interrelationships between indices of longitudinal movement of the common carotid artery wall and the conventional measures of subclinical arteriosclerosis (2017)
- Clinical Physiology and Functional Imaging
Taivainen SH, Yli-Ollila H,Juonala M, Kähönen M, Raitakari OT, Laitinen TM, Laitinen TP
(A1 Refereed original research article in a scientific journal)
- Low Childhood Cholesterol Absorption Predisposes to Gallstone Disease. The Cardiovascular Risk in Young Finns Study (2017)
- Journal of Pediatric Gastroenterology and Nutrition
Nissinen MJ, Simonen P, Gylling H, Viikari J, Hutri-Kähönen N, Jokinen E, Tossavainen P, Laitinen T, Raitakari O, Juonala M, Pakarinen MP
(A1 Refereed original research article in a scientific journal)
- Low serum adiponectin levels in childhood and adolescence predict increased intima-media thickness in adulthood. The Cardiovascular Risk in Young Finns Study (2017) Saarikoski Liisa A, Juonala Markus, Huupponen Risto, Viikari Jorma S. A., Lehtimäki Terho, Jokinen Eero, Hutri-Kähönen Nina, Taittonen Leena, Laitinen Tomi, Raitakari Olli T.
(A1 Refereed original research article in a scientific journal)
- Metabolic profiling of fatty liver in young and middle-aged adults: Cross-sectional and prospective analyses of the Young Finns Study (2017) Kaikkonen JE, Würtz P, Suomela E, Lehtovirta M, Kangas AJ, Jula A, Mikkilä V, Viikari JS, Juonala M, Rönnemaa T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Soininen P, Ala-Korpela M, Raitakari OT
(A1 Refereed original research article in a scientific journal)
- Positive Psychosocial Factors in Childhood Predicting Lower Risk for Adult Type 2 Diabetes: The Cardiovascular Risk in Young Finns Study, 1980-2012 (2017)
- American Journal of Preventive Medicine
Pulkki-Råback L, Elovainio M, Hakulinen C, Lipsanen J, Kubzansky LD, Hintsanen M, Savelieva K, Serlachius A, Magnussen CG, Sabin MA, Burgner DP, Lehtimäki T, Jokinen E, Rönnemaa T, Mikkilä V, Jula A, Hutri-Kähönen N, Viikari J, Keltikangas-Jarvinen L, Raitakari O, Juonala M
(A1 Refereed original research article in a scientific journal)
- Prediction of Adult Dyslipidemia Using Genetic and Childhood Clinical Risk Factors - The Cardiovascular Risk in Young Finns Study (2017)
- Circulation: Cardiovascular Genetics
Nuotio J, Pitkänen N, Magnussen CG, Buscot MJ, Venäläinen M, Elo LL, Jokinen E, Laitinen T, Taittonen L, Hutri-Kähönen N, Lyytikäinen LP, Lehtimäki T, Viikari JS, Juonala M, Raitakari OT
(A1 Refereed original research article in a scientific journal)
- Prediction of adulthood obesity using genetic and childhood clinical risk factors in the Cardiovascular Risk in Young Finns Study (2017)
- Circulation: Cardiovascular Genetics
Seyednasrollah F, Mäkelä J, Pitkänen N, Juonala M, Hutri-Käkönen N, Lehtimäki T, Viikari J, Kelly T, Li C, Bazzano L, Elo LL, Raitakari OT
(A1 Refereed original research article in a scientific journal)
- Pregnancy complications and later vascular ultrasound measures: A cohort study (2017) Emily W. Harville, Markus Juonala, Jorma S.A. Viikari, Mika Kähönen, Olli T. Raitakari
(A1 Refereed original research article in a scientific journal)
- Psychosocial environment in childhood and body mass index growth over 32 years (2017) Elovainio M, Pulkki-Råback L, Hakulinen C, Lehtimäki T, Jokinen E, Rönnemaa T, Mikkilä V, Tossavainen P, Jula A, Hutri-Kähönen N, Viikari J, Keltikangas-Järvinen L, Raitakari O, Juonala M
(A1 Refereed original research article in a scientific journal)
- Self-rated health as an indicator of ideal cardiovascular health among working-aged women (2017)
- Scandinavian Journal of Primary Health Care
Veromaa V, Kautiainen H, Juonala M, Rantanen A, Korhonen PE
(A1 Refereed original research article in a scientific journal)
- Socioeconomic Position Is Associated With Carotid Intima-Media Thickness in Mid-Childhood: The Longitudinal Study of Australian Children (2017)
- Journal of the American Heart Association
Liu RS, Mensah FK, Carlin J, Edwards B, Ranganathan S, Cheung M, Dwyer T, Saffery R, Magnussen CG, Juonala M, Wake M, Burgner DP; Child Health CheckPoint Investigator Group
(A1 Refereed original research article in a scientific journal)
