Markus Juonala
Professor
mataju@utu.fi +358 29 450 2754 +358 50 478 3572 ORCID identifier: https://orcid.org/0000-0001-9498-364X |
Internal medicine; endocrinology; cardiovascular risk
Cardiovascular epidemiology, Young Finns Study, i3c consortium
Professor Markus Juonala (MD,
PhD, University of Turku) is a specialist in internal medicine and
endocrinology at the Turku University Hospital, Turku, Finland. Since 2001, he
has been conducting research on longitudinal studies examining the importance
of childhood risk factors on later cardiovascular health. His PhD work was
based primarily on the Cardiovascular Risk in Young Finns Study (University of
Turku, April 2005). Since 2008, he has had a major involvement in the
development of the International Childhood Cardiovascular Cohort (i3C)
Consortium that combines the efforts of the main longitudinal studies
worldwide. In June 2014, he was appointed as Professor of Internal Medicine at
the University of Turku. In 2014-2015 and 2018-2019 he has been working as the Dame Elisabeth Murdoch Fellow in Murdoch Childrens Research Institute
(MCRI).
His career
publications total is 270 (h-index 44) with published highlights including a
first-author paper in the New England Journal of Medicine, the first-ranked
general medicine journal, one paper in JAMA, the third-ranked general medicine
journal and 30 papers (11 as first/last author) published in either the number
one, two, or three ranked cardiovascular disease journals (17 in Circulation,
five in the Journal of the American College of Cardiology, eight in the
European Heart Journal).
Professor Juonala’s
principal research focus has been to provide novel information on the effects
of childhood risk factors on cardiovascular health in adulthood. Beginning from
the summer of 2008 he has led a research group within the Young Finns Study and
i3c consortium with special interest on cardiometabolic risk factors. The most
important findings of his research have provided information on childhood and
early adulthood risk factors for atherosclerosis, suggesting that childhood
risk factors, such as dyslipidaemia, elevated blood pressure and smoking,
predict early atherosclerosis and its progression independent of adult risk
factors levels. Concerning cardiometabolic risk factors, his group has been
able to show that overweight and metabolic syndrome diagnosed either in childhood or adulthood
is predictive of carotid atherosclerosis and its progression in adulthood.
However, at the time of obesity epidemic, the most important findings concern
the reversibility of cardiovascular risk. His work has demonstrated that although overweight and metabolic syndrome are predictive of early atherosclerosis, favourable changes
in lifestyle associated with weight maintenance or reduction improve
cardiovascular health.
Teaching responsibilities: 1) Internal medicine for medical students, 2) Internal medicine specialisation programme for MDs
Special interest areas: Acute internal medicine, endocrinology, lipidology
- Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020)
- Nature
(A1 Refereed original research article in a scientific journal) - Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study (2020)
- BONE
(A1 Refereed original research article in a scientific journal) - Longitudinal association of a body mass index (BMI) genetic risk score with growth and BMI changes across the life course: The Cardiovascular Risk in Young Finns Study (2020)
- International Journal of Obesity
(A1 Refereed original research article in a scientific journal) - Lower grip strength in youth with obesity identifies those with increased cardiometabolic risk (2020)
- Obesity Research and Clinical Practice
(A1 Refereed original research article in a scientific journal) - Non-HDL Cholesterol Levels in Childhood and Carotid Intima-Media Thickness in Adulthood (2020)
- Pediatrics
(A1 Refereed original research article in a scientific journal) - Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers (2020)
- Nature Medicine
(A1 Refereed original research article in a scientific journal) - Polygenic Hyperlipidemias and Coronary Artery Disease Risk (2020)
- Circulation: Genomic and Precision Medicine
(A1 Refereed original research article in a scientific journal) - Prediction of adult class II/III obesity from childhood BMI: the i3C consortium (2020)
- International Journal of Obesity
(A1 Refereed original research article in a scientific journal) - Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma (2020)
- PLoS Genetics
(A1 Refereed original research article in a scientific journal) - Sepelvaltimotaudin primaari- ja sekundaariprevention tilanne Suomessa (2020)
- Sydänääni: Suomen Kardiologisen Seuran Lehti
(D1 Article in a professional journal) - Socioeconomic status, remoteness and tracking of nutritional status from childhood to adulthood in an Australian Aboriginal Birth Cohort: the ABC study (2020)
- BMJ Open
(A1 Refereed original research article in a scientific journal) - Systemic vascular resistance predicts the development of hypertension: the cardiovascular risk in young Finns study (2020)
- Blood Pressure
(A1 Refereed original research article in a scientific journal) - The associations of physical activity and physical capability with cardiovascular health among working-age finnish women (2020)
- Translational sports medicine
(A1 Refereed original research article in a scientific journal) - The "Goldilocks Day" for Children's Skeletal Health: Compositional Data Analysis of 24-Hour Activity Behaviors (2020)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - The role of polygenic risk and susceptibility genes in breast cancer over the course of life (2020)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan (2020)
- Nature Medicine
(A1 Refereed original research article in a scientific journal) - Youth to adult body mass index trajectories as a predictor of metabolically healthy obesity in adulthood (2020)
- European Journal of Public Health
(A1 Refereed original research article in a scientific journal) - A Cross-Cohort Study Examining the Associations of Metabolomic Profile and Subclinical Atherosclerosis in Children and Their Parents: The Child Health CheckPoint Study and Avon Longitudinal Study of Parents and Children (2019)
- Journal of the American Heart Association
(A1 Refereed original research article in a scientific journal) - Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood (2019)
- Nature Communications
Bowon Kim, Alexandra Sexton-Oates, Markus Juonala, Karin Hammarberg, David J. Amor,
Lex W. Doyle, Sarath Ranganathan, Liam Welsh, Michael Cheung, John McBain,
Robert McLachlan, Richard Saffery
(A1 Refereed original research article in a scientific journal) - Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood (2019)
- JAMA Network Open
(A1 Refereed original research article in a scientific journal)