Markus Juonala
 Professor


mataju@utu.fi

+358 29 450 2754

+358 50 478 3572




ORCID identifier: https://orcid.org/0000-0001-9498-364X

Areas of expertise
Internal medicine; endocrinology; cardiovascular risk

Research community or research topic
Cardiovascular epidemiology, Young Finns Study, i3c consortium

Biography

Professor Markus Juonala (MD,
PhD, University of Turku) is a specialist in internal medicine and
endocrinology at the Turku University Hospital, Turku, Finland. Since 2001, he
has been conducting research on longitudinal studies examining the importance
of childhood risk factors on later cardiovascular health. His PhD work was
based primarily on the Cardiovascular Risk in Young Finns Study (University of
Turku, April 2005). Since 2008, he has had a major involvement in the
development of the International Childhood Cardiovascular Cohort (i3C)
Consortium that combines the efforts of the main longitudinal studies
worldwide. In June 2014, he was appointed as Professor of Internal Medicine at
the University of Turku. In 2014-2015 and 2018-2019 he has been working as the Dame Elisabeth Murdoch Fellow in Murdoch Childrens Research Institute
(MCRI). 

His career
publications total is 270 (h-index 44) with published highlights including a
first-author paper in the New England Journal of Medicine, the first-ranked
general medicine journal, one paper in JAMA, the third-ranked general medicine
journal and 30 papers (11 as first/last author) published in either the number
one, two, or three ranked cardiovascular disease journals (17 in Circulation,
five in the Journal of the American College of Cardiology, eight in the
European Heart Journal). 



Research

Professor Juonala’s
principal research focus has been to provide novel information on the effects
of childhood risk factors on cardiovascular health in adulthood. Beginning from
the summer of 2008 he has led a research group within the Young Finns Study and
i3c consortium with special interest on cardiometabolic risk factors. The most
important findings of his research have provided information on childhood and
early adulthood risk factors for atherosclerosis, suggesting that childhood
risk factors, such as dyslipidaemia, elevated blood pressure and smoking,
predict early atherosclerosis and its progression independent of adult risk
factors levels. Concerning cardiometabolic risk factors, his group has been
able to show that overweight and metabolic syndrome diagnosed either in childhood or adulthood
is predictive of carotid atherosclerosis and its progression in adulthood.
However, at the time of obesity epidemic, the most important findings concern
the reversibility of cardiovascular risk. His work has demonstrated that although overweight and metabolic syndrome are predictive of early atherosclerosis, favourable changes
in lifestyle associated with weight maintenance or reduction improve
cardiovascular health.

 




Teaching

Teaching responsibilities: 1) Internal medicine for medical students, 2) Internal medicine specialisation programme for MDs

Special interest areas: Acute internal medicine, endocrinology, lipidology

  



Publications
  
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  • Lifetime measures of ideal cardiovascular health and their association with subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study  (2015)  
    • International Journal of Cardiology
     Laitinen TT, Pahkala K, Magnussen CG, Oikonen M, Viikari JSA, Sabin MA, Daniels SR, Heinonen OJ, Taittonen L, Hartiala O, Mikkila V, Hutri-Kahonen N, Laitinen T, Kahonen M, Raitakari OT, Juonala M
    (    A1 Refereed original research article in a scientific journal)


  • Longitudinal investigation of adenovirus 36 seropositivity and human obesity: the Cardiovascular Risk in Young Finns Study  (2015)  
    • International Journal of Obesity
     Sabin MA, Burgner D, Atkinson RL, Lee ZPL, Magnussen CG, Cheung M, Kahonen M, Lehtimaki T, Jokinen E, Laitinen T, Hutri-Kahonen N, Viikari JSA, Juonala M, Raitakari OT
    (    A1 Refereed original research article in a scientific journal)


  • Metabolic Syndrome From Adolescence to Early Adulthood Effect of Infancy-Onset Dietary Counseling of Low Saturated Fat: The Special Turku Coronary Risk Factor Intervention Project (STRIP)  (2015)  
    • Circulation
     Nupponen M, Pahkala K, Juonala M, Magnussen CG, Niinikoski H, Ronnemaa T, Viikari JSA, Saarinen M, Lagstrom H, Jula A, Simell O, Raitakari OT
    (    A1 Refereed original research article in a scientific journal)


  • Paraoxonase-1 and oxidized lipoprotein lipids. The Cardiovascular Risk in Young Finns Study  (2015)  
    • Atherosclerosis
     Kresanov P, Vasankari T, Ahotupa M, Kaikkonen J, Hutri-Kahonen N, Juonala M, Kahonen M, Lehtimaki T, Viikari J, Raitakari OT
    (    A1 Refereed original research article in a scientific journal)


  • Prevalence and determinants of fatty liver in normal-weight and overweight young adults. The Cardiovascular Risk in Young Finns Study  (2015)  
    • Annals of Medicine
     Suomela E, Oikonen M, Virtanen J, Parkkola R, Jokinen E, Laitinen T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Taittonen L, Tossavainen P, Jula A, Loo BM, Mikkilä V, Younossi Z, Viikari JS, Juonala M, Raitakari OT
    (    A1 Refereed original research article in a scientific journal)


  • Stress-induced cardiac autonomic reactivity and preclinical atherosclerosis: does arterial elasticity modify the association?  (2015)  
    • Stress
     Chumaeva N, Hintsanen M, Pulkki-Råback L1, Merjonen P, Elovainio M, Hintsa T, Juonala M, Kähönen M, Raitakari OT, Keltikangas-Järvinen L
    (    A1 Refereed original research article in a scientific journal)


  • Subtle increases in heart size persist into adulthood in growth restricted babies: the Cardiovascular Risk in Young Finns Study.  (2015)  
    • Open Heart
     Clare Arnott, Michael R Skilton, Saku Ruohonen, Markus Juonala, Jorma S A Viikari, Mika Kähönen, Terho Lehtimäki, Tomi Laitinen, David S Celermajer, Olli T Raitakari
    (    A1 Refereed original research article in a scientific journal)


  • Television viewing and fatty liver in early midlife. The Cardiovascular Risk in Young Finns Study  (2015)  
    • Annals of Medicine
     Helajarvi H, Pahkala K, Heinonen OJ, Juonala M, Oikonen M, Tammelin T, Hutri-Kahonen N, Lehtimaki T, Mikkila V, Viikari J, Raitakari OT
    (    A1 Refereed original research article in a scientific journal)


  • The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection  (2015)  
    • Cell Systems
     Ritchie SC, Würtz P, Nath AP, Abraham G, Havulinna AS, Fearnley LG, Sarin A-P, Kangas AJ, Soininen P, Aalto K, Seppälä I, Raitoharju E, Salmi M, Maksimow M, Männistö S, Kähönen M, Juonala M, Ripatti S, Lehtimäki T, Jalkanen S, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, Inouye M
    (    A1 Refereed original research article in a scientific journal)


  • The effect of antidepressants and antipsychotics on weight gain in children and adolescents  (2015)  
    • Obesity Reviews
     Reekie J, Hosking SPM, Prakash C, Kao KT, Juonala M, Sabin MA
    (    A2 Refereed review article in a scientific journal )


  • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study  (2015)  
    • PLoS Genetics
     Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpelainen TO, Lu YC, Magi R, Mihailov E, Pers TH, Rueger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJM, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CWK, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson A, Kaakinen M, Kleber ME, Lahti J, Leach IM, Lehne B, Liu YF, Lo KS, Lorentzon M, Luan J, Madden PAF, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Muller G, Muller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renstrom F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi JX, Smith AV, Southam L, Stancakova A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang ZM, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang WH, Zhao JH, Andersson EA, Bakker SJL, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Bluher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YDI, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJC, de Groot LCPGM, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Grassler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kahonen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jorgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Kruger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindstrom J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Mannisto S, Magnusson PK, McArdle WL, Menni C, Merger S, Milani L, Montgomery GW, Morris AP, Narisu N, Nelis M, Ong KK, Palotie A, Perusse L, Pichler I, Pilia MG, Pouta A, Rheinberger M, Ribel-Madsen R, Richards M, Rice KM, Rice TK, Rivolta C, Salomaa V, Sanders AR, Sarzynski MA, Scholtens S, Scott RA, Scott WR, Sebert S, Sengupta S, Sennblad B, Seufferlein T, Silveira A, Slagboom PE, Smit JH, Sparso TH, Stirrups K, Stolk RP, Stringham HM, Swertz MA, Swift AJ, Syvanen AC, Tan ST, Thorand B, Tonjes A, Tremblay A, Tsafantakis E, van der Most PJ, Volker U, Vohl MC, Vonk JM, Waldenberger M, Walker RW, Wennauer R, Widen E, Willemsen G, Wilsgaard T, Wright AF, Zillikens MC, van Dijk SC, van Schoor NM, Asselbergs FW, de Bakker PIW, Beckmann JS, Beilby J, Bennett DA, Bergman RN, Bergmann S, Boger CA, Boehm BO, Boerwinkle E, Boomsma DI, Bornstein SR, Bottinger EP, Bouchard C, Chambers JC, Chanock SJ, Chasman DI, Cucca F, Cusi D, Dedoussis G, Erdmann J, Eriksson JG, Evans DA, de Faire U, Farrall M, Ferrucci L, Ford I, Franke L, Franks PW, Froguel P, Gansevoort RT, Gieger C, Gronberg H, Gudnason V, Gyllensten U, Hall P, Hamsten A, van der Harst P, Hayward C, Heliovaara M, Hengstenberg C, Hicks AA, Hingorani A, Hofman A, Hu F, Huikuri HV, Hveem K, James AL, Jordan JM, Jula A, Kahonen M, Kajantie E, Kathiresan S, Kiemeney LALM, Kivimaki M, Knekt PB, Koistinen HA, Kooner JS, Koskinen S, Kuusisto J, Maerz W, Martin NG, Laakso M, Lakka TA, Lehtimaki T, Lettre G, Levinson DF, Lind L, Lokki ML, Mantyselka P, Melbye M, Metspalu A, Mitchell BD, Moll FL, Murray JC, Musk AW, Nieminen MS, Njolstad I, Ohlsson C, Oldehinkel AJ, Oostra BA, Palmer LJ, Pankow JS, Pasterkamp G, Pedersen NL, Pedersen O, Penninx BW, Perola M, Peters A, Polasek O, Pramstaller PP, Psaty BM, Qi L, Quertermous T, Raitakari OT, Rankinen T, Rauramaa R, Ridker PM, Rioux JD, Rivadeneira F, Rotter JI, Rudan I, den Ruijter HM, Saltevo J, Sattar N, Schunkert H, Schwarz PEH, Shuldiner AR, Sinisalo J, Snieder H, Sorensen TIA, Spector TD, Staessen JA, Stefania B, Thorsteinsdottir U, Stumvoll M, Tardif JC, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Verbeek ALM, Vermeulen SH, Viikari JS, Vitart V, Volzke H, Vollenweider P, Waeber G, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Zeggini E, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, Abecasis GR, Assimes TL, Barroso I, Berndt SI, Boehnke M, Deloukas P, Fox CS, Groop LC, Hunter DJ, Ingelsson E, Kaplan RC, McCarthy MI, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Hirschhorn JN, Lindgren CM, Heid IM, North KE, Borecki IB, Kutalik Z, Loos RJF
    (    A1 Refereed original research article in a scientific journal)


  • Uudet preventiolääkkeet  (2015)  
    • Sydänääni: Suomen Kardiologisen Seuran Lehti
     Juonala M
    (    D1 Article in a professional journal)


  • Viewpoint article: Childhood obesity - looking back over 50 years to begin to look forward  (2015)  
    • Journal of Paediatrics and Child Health
     Sabin MA, Kao KT, Juonala M, Baur LA, Wake M
    (    A2 Refereed review article in a scientific journal )


  • Vigorous physical activity and carotid distensibility in young and mid-aged adults  (2015)  
    • Hypertension Research
     Huynh QL, Blizzard CL, Raitakari O, Sharman JE, Magnussen CG, Dwyer T, Juonala M, Kahonen M, Venn AJ
    (    A1 Refereed original research article in a scientific journal)


  • Association of physical activity in childhood and early adulthood with carotid artery elasticity 21 years later: the cardiovascular risk in Young Finns Study.  (2014)  
    • Journal of the American Heart Association
     Pälve KS, Pahkala K, Magnussen CG, Koivistoinen T, Juonala M, Kähönen M, Lehtimäki T, Rönnemaa T, Viikari JS, Raitakari OT
    (    A1 Refereed original research article in a scientific journal)


  • Association of thyrotropin with arterial pulse wave velocity in young adults: The Cardiovascular Risk in Young Finns Study  (2014)  
    • Scandinavian Journal of Clinical and Laboratory Investigation
     Hjelt S., Heikki Aatola M., Kähönen M., Juonala M., Koivistoinen T., Lehtimäki T., Viikari J., Raitakari O., Laitinen T., Hutri-Kähönen N.
    (    A1 Refereed original research article in a scientific journal)


  • Cardiovascular risk factors in 2011 and secular trends since 2007: The Cardiovascular Risk in Young Finns Study.  (2014)  
    • Scandinavian Journal of Public Health
     Nuotio J, Oikonen M, Magnussen CG, Jokinen E, Laitinen T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Taittonen L, Tossavainen P, Jula A, Loo BM, Viikari JS, Raitakari OT, Juonala M
    (    A1 Refereed original research article in a scientific journal)


  • Carotid artery elasticity decreases during pregnancy - the Cardiovascular Risk in Young Finns study  (2014)  
    • BMC Pregnancy and Childbirth
     Karkkainen H, Saarelainen H, Valtonen P, Laitinen T, Raitakari OT, Juonala M, Kahonen M, Hutri-Kahonen N, Heinonen S, Laitinen T
    (    A1 Refereed original research article in a scientific journal)


  • Exposure to parental smoking in childhood or adolescence is associated with increased carotid intima-media thickness in young adults: evidence from the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health Study  (2014)  
    • European Heart Journal
     Gall S, Huynh QL, Magnussen CG, Juonala M, Viikari JSA, Kahonen M, Dwyer T, Raitakari OT, Venn A
    (    A1 Refereed original research article in a scientific journal)


  • Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality  (2014)  
    • European Heart Journal
     Seppala I, Kleber ME, Lyytikainen LP, Hernesniemi JA, Makela KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kahonen N, Alfthan G, Viikari JSA, Kahonen M, Raitakari OT, Marz W, Meinitzer A, Lehtimaki T
    (    A1 Refereed original research article in a scientific journal)



Last updated on 2023-12-07 at 12:00