Markus Juonala
Professor
Areas of expertise
Internal medicine; endocrinology; cardiovascular risk
Research community or research topic
Cardiovascular epidemiology, Young Finns Study, i3c consortium
Biography
Professor Markus Juonala (MD,
PhD, University of Turku) is a specialist in internal medicine and
endocrinology at the Turku University Hospital, Turku, Finland. Since 2001, he
has been conducting research on longitudinal studies examining the importance
of childhood risk factors on later cardiovascular health. His PhD work was
based primarily on the Cardiovascular Risk in Young Finns Study (University of
Turku, April 2005). Since 2008, he has had a major involvement in the
development of the International Childhood Cardiovascular Cohort (i3C)
Consortium that combines the efforts of the main longitudinal studies
worldwide. In June 2014, he was appointed as Professor of Internal Medicine at
the University of Turku. In 2014-2015 and 2018-2019 he has been working as the Dame Elisabeth Murdoch Fellow in Murdoch Childrens Research Institute
(MCRI).
His career
publications total is 270 (h-index 44) with published highlights including a
first-author paper in the New England Journal of Medicine, the first-ranked
general medicine journal, one paper in JAMA, the third-ranked general medicine
journal and 30 papers (11 as first/last author) published in either the number
one, two, or three ranked cardiovascular disease journals (17 in Circulation,
five in the Journal of the American College of Cardiology, eight in the
European Heart Journal).
Research
Professor Juonala’s
principal research focus has been to provide novel information on the effects
of childhood risk factors on cardiovascular health in adulthood. Beginning from
the summer of 2008 he has led a research group within the Young Finns Study and
i3c consortium with special interest on cardiometabolic risk factors. The most
important findings of his research have provided information on childhood and
early adulthood risk factors for atherosclerosis, suggesting that childhood
risk factors, such as dyslipidaemia, elevated blood pressure and smoking,
predict early atherosclerosis and its progression independent of adult risk
factors levels. Concerning cardiometabolic risk factors, his group has been
able to show that overweight and metabolic syndrome diagnosed either in childhood or adulthood
is predictive of carotid atherosclerosis and its progression in adulthood.
However, at the time of obesity epidemic, the most important findings concern
the reversibility of cardiovascular risk. His work has demonstrated that although overweight and metabolic syndrome are predictive of early atherosclerosis, favourable changes
in lifestyle associated with weight maintenance or reduction improve
cardiovascular health.
Teaching
Teaching responsibilities: 1) Internal medicine for medical students, 2) Internal medicine specialisation programme for MDs
Special interest areas: Acute internal medicine, endocrinology, lipidology
Publications
- Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis (2018) Santosh D. Bhosale, Robert Moulder, Mikko S. Venäläinen, Juhani S. Koskinen, Niina Pitkänen, Markus T. Juonala, Mika A. P. Kähönen, Terho J. Lehtimäki, Jorma S. A. Viikari, Laura L. Elo, David R. Goodlett, Riitta Lahesmaa, Olli T. Raitakari
(A1 Refereed original research article in a scientific journal)
- Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids (2018) Laitinen TT, Nuotio J, Juonala M, Niinikoski H, Rovio S, Viikari JSA, Ronnemaa T, Magnussen CG, Jokinen E, Lagstrom H, Jula A, Simell O, Raitakari OT, Pahkala K
(A1 Refereed original research article in a scientific journal)
- The International Childhood Cardiovascular Cohort (i3C) consortium outcomes study of childhood cardiovascular risk factors and adult cardiovascular morbidity and mortality: Design and recruitment (2018)
- Contemporary Clinical Trials
Alan R. Sinaiko, David R. Jacobs Jr, Jessica G. Woo, Lydia Bazzano, Trudy Burns, Tian Hu, Markus Juonala, Ronald Prineas, Olli Raitakari, Julia Steinberger, Elaine Urbina, Alison Venn, Cashell Jaquish, Terry Dwyer
(A1 Refereed original research article in a scientific journal)
- Accumulation of Depressive Symptoms and Carotid Intima-Media Thickness: the Cardiovascular Risk in Young Finns Study (2017)
- Annals of Behavioral Medicine
Keltikangas-Jarvinen L, Savelieva K, Josefsson K, Elovainio M, Pulkki-Raback L, Juonala M, Raitakari OT, Hintsanen M
(A1 Refereed original research article in a scientific journal)
- An interaction map of circulating metabolites, immune gene networks, and their genetic regulation (2017) Nath AP, Ritchie SC, Byars SG, Fearnley LG, Havulinna AS, Joensuu A, Kangas AJ, Soininen P, Wennerstrom A, Milani L, Metspalu A, Mannisto S, Wurtz P, Kettunen J, Raitoharju E, Kahonen M, Juonala M, Palotie A, Ala-Korpela M, Ripatti S, Lehtimaki T, Juonala M, Raitakari O, Salomaa V, Perola M, Inouye M
(A1 Refereed original research article in a scientific journal)
- Association of Socioeconomic Status in Childhood With Left Ventricular Structure and Diastolic Function in Adulthood The Cardiovascular Risk in Young Finns Study (2017) Laitinen TT, Puolakka E, Ruohonen S, Magnussen CG, Smith KJ, Viikari JSA, Heinonen OJ, Kartiosuo N, Hutri-Kahonen N, Kahonen M, Jokinen E, Laitinen TP, Tossavainen P, Pulkki-Raback L, Elovainio M, Raitakari OT, Pahkala K, Juonala M
(A1 Refereed original research article in a scientific journal)
- Bayesian hierarchical piecewise regression models: a tool to detect trajectory divergence between groups in long-term observational studies (2017)
- BMC Medical Research Methodology
Buscot MJ, Wotherspoon SS, Magnussen CG, Juonala M, Sabin MA, Burgner DP, Lehtimäki T, Viikari JSA, Hutri-Kähönen N, Raitakari OT, Thomson RJ
(A1 Refereed original research article in a scientific journal)
- Blood pathway analyses reveal differences between prediabetic subjects with or without dyslipidaemia. The Cardiovascular Risk in Young Finns Study (2017)
- Diabetes/Metabolism Research and Reviews
Laaksonen J, Taipale T, Seppala I, Raitoharju E, Mononen N, Lyytikainen LP, Waldenberger M, Illig T, Hutri-Kahonen N, Ronnemaa T, Juonala M, Viikari J, Kahonen M, Raitakari O, Lehtimaki T
(A1 Refereed original research article in a scientific journal)
- Cardiometabolic Determinants of Carotid and Aortic Distensibility From Childhood to Early Adulthood (2017) Mikola H, Pahkala K, Niinikoski H, Ronnemaa T, Viikari JSA, Jula A, Juonala M, Raitakari OT
(A1 Refereed original research article in a scientific journal)
- Cardiorespiratory Fitness and Risk of Fatty Liver: The Young Finns Study (2017)
- Medicine and Science in Sports and Exercise
Palve KS, Pahkala K, Suomela E, Aatola H, Hulkkonen J, Juonala M, Lehtimaki T, Ronnemaa T, Viikari JSA, Kahonen M, Hutri-Kahonen N, Telama R, Tammelin T, Raitakari OT
(A1 Refereed original research article in a scientific journal)
- Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study (2017)
- Journal of the American College of Cardiology
Suvi P. Rovio, Katja Pahkala, Jaakko Nevalainen, Markus Juonala, Pia Salo, Mika Kähönen, Nina Hutri-Kähönen, Terho Lehtimäki, Eero Jokinen, Tomi Laitinen, Leena Taittonen, Päivi Tossavainen, Jorma S.A. Viikari, Juha O. Rinne, Olli T. Raitakari
(A1 Refereed original research article in a scientific journal)
- Childhood age and associations between childhood metabolic syndrome and adult risk for metabolic syndrome, type 2 diabetes mellitus and carotid intima media thickness: The international childhood cardiovascular cohort consortium (2017)
- Journal of the American Heart Association
Juha Koskinen, Costan G. Magnussen, Alan Sinaiko, Jessica Woo, Elaine Urbina, David R. Jacobs, Julia Steinberger, Ronald Prineas, Matthew A. Sabin, Trudy Burns, Gerald Berenson, Lydia Bazzano, Alison Venn, Jorma S.A. Viikari, Nina Hutri‐Kähönen, Olli Raitakari, Terence Dwyer, Markus Juonala
(A1 Refereed original research article in a scientific journal)
- Childhood Socioeconomic Status and Arterial Stiffness in Adulthood The Cardiovascular Risk in Young Finns Study (2017) Puolakka E, Pahkala K, Laitinen TT, Magnussen CG, Hutri-Kahonen N, Kahonen M, Lehtimaki T, Tossavainen P, Jokinen E, Sabin MA, Laitinen T, Elovainio M, Pulkki-Raback L, Viikari JSA, Raitakari OT, Juonala M
(A1 Refereed original research article in a scientific journal)
- Clinical review of 24-35 year olds conceived with and without in vitro fertilization: study protocol (2017) Lewis S, Kennedy J, Burgner D, McLachlan R, Ranganathan S, Hammarberg K, Saffery R, Amor DJ, Cheung MMH, Doyle LW, Juonala M, Donath S, McBain J, Halliday J
(A2 Refereed review article in a scientific journal )
- Does high optimism protect against the inter-generational transmission of high BMI? The Cardiovascular Risk in Young Finns Study (2017)
- Journal of Psychosomatic Research
Serlachius A, Pulkki-Raback L, Juonala M, Sabin M, Lehtimaki T, Raitakari O, Elovainio M
(A1 Refereed original research article in a scientific journal)
- Exposure to Parental Smoking in Childhood is Associated with High C-Reactive Protein in Adulthood: The Cardiovascular Risk in Young Finns Study (2017)
- Journal of Atherosclerosis and Thrombosis
Wang D, Juonala M, Viikari JSA, Wu F, Hutri-Kähönen N, Raitakari OT, Magnussen CG
(A1 Refereed original research article in a scientific journal)
- Fasting Glucose and the Risk of Depressive Symptoms: Instrumental-Variable Regression in the Cardiovascular Risk in Young Finns Study (2017)
- International Journal of Behavioral Medicine
Karolina Wesołowska, Marko Elovainio, Taina Hintsa, Markus Jokela, Laura Pulkki-Råback, Niina Pitkänen, Jari Lipsanen, Janne Tukiainen, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Markus Juonala, Olli Raitakari, Liisa Keltikangas-Järvinen
(A1 Refereed original research article in a scientific journal)
- Fasting glucose and the risk of depressive symptoms: Instrumental-variable regression in the Cardiovascular Risk in Young Finns Study (2017)
- International Journal of Behavioral Medicine
Wesołowska K, Elovainio M, Hintsa T, Jokela M, Pulkki-Råback L, Pitkänen N, Lipsanen J, Tukiainen J, Lyytikäinen LP, Lehtimäki T, Juonala M, Raitakari O, Keltikangas-Järvinen L
(A1 Refereed original research article in a scientific journal)
- Genetic loci associated with heart rate variability and their effects on cardiac disease risk (2017) Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikainen LP, Maihofer AX, Minassian A, van der Most PJ, Muller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen IE, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kahonen N, Ashar F, Ashar F, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao DP, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundstrom J, Swenne CA, Syvanen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong QN, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Jarvelin MR, Kaab S, Kahonen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimaki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC
(A1 Refereed original research article in a scientific journal)
- Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits (2017) Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, Ngwa JS, Ahluwalia TS, Chu AY, Heard-Costa NL, Lim E, Perez J, Eicher JD, Kutalik Z, Xue L, Mahajan A, Renstrom F, Wu J, Qi QB, Ahmad S, Alfred T, Amin N, Bielak LF, Bonnefond A, Bragg J, Cadby G, Chittani M, Coggeshall S, Corre T, Direk N, Eriksson J, Fischer K, Gorski M, Harder MN, Horikoshi M, Huang T, Huffman JE, Jackson AU, Justesen JM, Kanoni S, Kinnunen L, Kleber ME, Komulainen P, Kumari M, Lim U, Luan J, Lyytikainen LP, Mangino M, Manichaikul A, Marten J, Middelberg RPS, Mueller-Nurasyid M, Navarro P, Perusse L, Pervjakova N, Sarti C, Smith AV, Smith JA, Stancakova A, Strawbridge RJ, Stringham HM, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van der Most PJ, Van Vliet-Ostaptchouk JV, Vedantam SL, Verweij N, Vink JM, Vitart V, Wu Y, Yengo L, Zhang WH, Zhao JH, Zimmermann ME, Zubair N, Abecasis GR, Adair LS, Afaq S, Afzal U, Bakker SJL, Bartz TM, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Braga D, Buckley BM, Buyske S, Campbell H, Chambers JC, Collins FS, Curran JE, de Borst GJ, de Craen AJM, de Geus EJC, Dedoussis G, Delgado GE, den Ruijter HM, Eiriksdottir G, Eriksson AL, Esko T, Faul JD, Ford I, Forrester T, Gertow K, Gigante B, Glorioso N, Gong J, Grallert H, Grammer TB, Grarup N, Haitjema S, Hallmans G, Hamsten A, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie ND, Heath AC, Hernandez D, Hindorff L, Hocking LJ, Hollensted M, Holmen OL, Homuth G, Hottenga JJ, Huang J, Hung J, Hutri-Kahonen N, Ingelsson E, James AL, Jansson JO, Jarvelin MR, Jhun MA, Jorgensen ME, Juonala M, Kahonen M, Karlsson M, Koistinen HA, Kolcic I, Kolovou G, Kooperberg C, Kramer BK, Kuusisto J, Kvaloy K, Lakka TA, Langenberg C, Launer LJ, Leander K, Lee NR, Lind L, Lindgren CM, Linneberg A, Lobbens S, Loh M, Lorentzon M, Luben R, Lubke G, Ludolph-Donislawski A, Lupoli S, Madden PAF, Mannikko R, Marques-Vidal P, Martin NG, McKenzie CA, McKnight B, Mellstrom D, Menni C, Montgomery GW, Musk AW, Narisu N, Nauck M, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Peyser PA, Pisinger C, Porteous DJ, Raitakari OT, Rankinen T, Rao DC, Rasmussen-Torvik LJ, Rawal R, Rice T, Ridker PM, Rose LM, Bien SA, Rudan I, Sanna S, Sarzynski MA, Sattar N, Savonen K, Schlessinger D, Scholtens S, Schurmann C, Scott RA, Sennblad B, Siemelink MA, Silbernagel G, Slagboom PE, Snieder H, Staessen JA, Stott DJ, Swertz MA, Swift AJ, Taylor KD, Tayo BO, Thorand B, Thuillier D, Tuomilehto J, Uitterlinden AG, Vandenput L, Vohl MC, Volzke H, Vonk JM, Waeber G, Waldenberger M, Westendorp RGJ, Wild S, Willemsen G, Wolffenbuttel BHR, Wong A, Wright AF, Zhao W, Zillikens MC, Baldassarre D, Balkau B, Bandinelli S, Boger CA, Boomsma DI, Bouchard C, Bruinenberg M, Chasman DI, Chen YDI, Chines PS, Cooper RS, Cucca F, Cusi D, de Faire U, Ferrucci L, Franks PW, Froguel P, Gordon-Larsen P, Grabe HJ, Gudnason V, Haiman CA, Hayward C, Hveem K, Johnson AD, Jukema W, Kardia SLR, Kivimaki M, Kooner JS, Kuh D, Laakso M, Lehtimaki T, Le Marchand L, Marz W, McCarthy MI, Metspalu A, Morris AP, Ohlsson C, Palmer LJ, Pasterkamp G, Pedersen O, Peters A, Peters U, Polasek O, Psaty BM, Qi L, Rauramaa R, Smith BH, Sorensen TIA, Strauch K, Tiemeier H, Tremoli E, Van der Harst P, Vestergaard H, Vollenweider P, Wareham NJ, Weir DR, Whitfield JB, Wilson JF, Tyrrell J, Frayling TM, Barroso I, Boehnke M, Deloukas P, Fox CS, Hirschhorn JN, Hunter DJ, Spector TD, Strachan DP, van Duijn CM, Heid IM, Mohlke KL, Marchini J, Loos RJF, Kilpelainen TO, Liu CT, Borecki IB, North KE, Cupples LA, Hunter DJ, Hirschhorn JN, Strachan DP, Spector TD, Heid IM, van Duijn CM, Marchini J, Mohlke KL, Kilpelainen TO, Loos RJF, Borecki IB, Liu CT, Cupples LA, North KE
(A1 Refereed original research article in a scientific journal)