MD/PhD Olli Raitakari - UTU Tutkimustietojärjestelmä

Olli Raitakari
MD/PhD

- professori,
väestötutkimuskeskus (lääketieteellinen tiedekunta)
- ,
InFLAMES Lippulaiva (lääketieteellinen tiedekunta)

olli.raitakari@utu.fi

+358 29 450 2304

Kiinamyllynkatu 10

Turku

ORCID-tunniste: https://orcid.org/0000-0001-9365-3702

10_representative_publications.pdf

Asiantuntijuusalueet

cardiovascular and metabolic diseases; risk factors; vascular epidemiology; genetic epidemiology; epidemiology; dietary intervention; cohort studies; follow-up studies

Biografia

EDUCATION AND DEGREES

2001   Docent in Clinical Physiology
1997-1999  Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997   Docent in Epidemiology
1996   Specialist in Clinical Physiology
1995   Doctorate, PhD
1989   Licentiate in Medicine, MD

CURRENT POSITIONS

2017- Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and
Preventive Cardiovascular Medicine, University of Turku, Finland

PAST POSITIONS

2012-2016 Academy Professor, University of Turku

2007-2016 Professor in Cardiovascular Medicine (part time), University of Turku

2007-2008 Senior Scientist Grant, Academy of Finland

2004-2016 Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
University Hospital (leave of absence 2012-2016)

2002-2004 Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital

2002 (1 mo) Head of Nuclear Medicine Department, Turku University Hospital

2000-2003 (3 mo) Head of Clinical Physiology Department, Turku University Hospital

2000-2005 Senior Fellow Post, Academy of Finland

1998-2000 Postdoctoral Research Post, Academy of Finland

1996-1997 Consultant in Clinical Physiology, Turku University Hospital

1991-1996 Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical
Physiology, Turku University Hospital

1988-1990 Positions as General Practioner and Resident in Internal Medicine or Surgery

Tutkimus

Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.

Julkaisut

35/53

Adult dyslipidemia prediction is improved by repeated measurements in childhood and young adulthood. The Cardiovascular Risk in Young Finns Study (2015)
- Atherosclerosis
Nuotio J, Oikonen M, Magnussen CG, Viikari JSA, Hutri-Kahonen N, Jula A, Thomson R, Sabin MA, Daniels SR, Raitakari OT, Juonala M
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Adulthood temperament and educational attainment: A population-based cohort study (2015)
- Learning and Instruction
Mullola S, Hintsanen M, Elovainio M, Pulkki-Raback L, Lipsanen J, Josefsson K, Lehtimaki T, Raitakari OT, Keltikangas-Jarvinen L
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism (2015)
- PLoS Genetics
Loukola A, Buchwald J, Gupta R, Palviainen T, Hallfors J, Tikkanen E, Korhonen T, Ollikainen M, Sarin AP, Ripatti S, Lehtimaki T, Raitakari O, Salomaa V, Rose RJ, Tyndale RF, Kaprio J
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure (2015)
- Human Genetics
Turpeinen H, Seppala I, Lyytikainen LP, Raitoharju E, Hutri-Kahonen N, Levula M, Oksala N, Waldenberger M, Klopp N, Illig T, Mononen N, Laaksonen R, Raitakari O, Kahonen M, Lehtimaki T, Pesu M
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
A novel common variant in DCST2 is associated with length in early life and height in adulthood (2015)
- Human Molecular Genetics
van der Valk RJP, Kreiner-Moller E, Kooijman MN, Guxens M, Stergiakouli E, Saaf A, Bradfield JP, Geller F, Hayes MG, Cousminer DL, Korner A, Thiering E, Curtin JA, Myhre R, Huikari V, Joro R, Kerkhof M, Warrington NM, Pitkanen N, Ntalla I, Horikoshi M, Veijola R, Freathy RM, Teo YY, Barton SJ, Evans DM, Kemp JP, St Pourcain B, Ring SM, Smith GD, Bergstrom A, Kull I, Hakonarson H, Mentch FD, Bisgaard H, Chawes B, Stokholm J, Waage J, Eriksen P, Sevelsted A, Melbye M, van Duijn CM, Medina-Gomez C, Hofman A, de Jongste JC, Taal HR, Uitterlinden AG, Armstrong LL, Eriksson J, Palotie A, Bustamante M, Estivill X, Gonzalez JR, Llop S, Kiess W, Mahajan A, Flexeder C, Tiesler CMT, Murray CS, Simpson A, Magnus P, Sengpiel V, Hartikainen AL, Keinanen-Kiukaanniemi S, Lewin A, Alves ADC, Blakemore AI, Buxton JL, Kaakinen M, Rodriguez A, Sebert S, Vaarasmaki M, Lakka T, Lindi V, Gehring U, Postma DS, Ang W, Newnham JP, Lyytikainen LP, Pahkala K, Raitakari OT, Panoutsopoulou K, Zeggini E, Boomsma DI, Groen-Blokhuis M, Ilonen J, Franke L, Hirschhorn JN, Pers TH, Liang L, Huang J, Hocher B, Knip M, Saw SM, Holloway JW, Melen E, Grant SFA, Feenstra B, Lowe WL, Widen E, Sergeyev E, Grallert H, Custovic A, Jacobsson B, Jarvelin MR, Atalay M, Koppelman GH, Pennell CE, Niinikoski H, Dedoussis GV, Mccarthy MI, Frayling TM, Sunyer J, Timpson NJ, Rivadeneira F, Bonnelykke K, Jaddoe VWV
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Association of adiponectin with adolescent cardiovascular health in a dietary intervention study (2015)
- Journal of Pediatrics
Jaakkola J, Pahkala K, Viitala M, Rönnemaa T, Viikari J, Niinikoski H, Lagström H, Jula A, Simell O, Raitakari O.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Biological interpretation of genome-wide association studies using predicted gene functions (2015)
- Nature Communications
Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L.; Genetic Investigation of ANthropometric Traits (GIANT) Consortium
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Childhood 25-OH Vitamin D Levels and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study (2015)
- Journal of Clinical Endocrinology and Metabolism
Juonala M, Voipio A, Pahkala K, Viikari JSA, Mikkila V, Kahonen M, Hutri-Kahonen N, Jula A, Burgner D, Sabin MA, Marniemi J, Loo BM, Laitinen T, Jokinen E, Taittonen L, Magnussen CG, Raitakari OT
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Childhood and adolescence risk factors and development of depressive symptoms: the 32-year prospective Young Finns follow-up study (2015)
- Journal of Epidemiology and Community Health
Elovainio M, Pulkki-Råback L, Hakulinen C, Ferrie JE, Jokela M, Hintsanen M, Raitakari OT, Keltikangas-Järvinen L
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies (2015)
- Cephalalgia
Nyholt DR, Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M, Malik R, de Vries B, Terwindt GM, Ikram MA, Stam AH, Ligthart L, Freilinger T, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Aromaa A, Eriksson JG, Kaprio J, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Quaye L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AMJM, Dichgans M, Wessman M, Smith GD, Stefansson K, Chasman DI, Palotie A
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians (2015)
- American Journal of Clinical Nutrition
Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV, Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkilä V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renström F, North KE, McKeown NM, Feitosa MF, Kanoni S, Smith CE, Garcia ME, Tiainen AM, Sonestedt E, Manichaikul A, van Rooij FJ, Dimitriou M, Raitakari O, Pankow JS, Djoussé L, Province MA, Hu FB, Lai CQ, Keller MF, Perälä MM, Rotter JI, Hofman A, Graff M, Kähönen M, Mukamal K, Johansson I, Ordovas JM, Liu Y, Männistö S, Uitterlinden AG, Deloukas P, Seppälä I, Psaty BM, Cupples LA, Borecki IB, Franks PW, Arnett DK, Nalls MA, Eriksson JG, Orho-Melander M, Franco OH, Lehtimäki T, Dedoussis GV, Meigs JB, Siscovick DS
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Coronary heart disease risk factors, coronary artery calcification and epicardial fat volume in the Young Finns Study (2015)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
Hartiala O, Magnussen CG, Bucci M, Kajander S, Knuuti J, Ukkonen H, Saraste A, Rinta-Kiikka I, Kainulainen S, Kähönen M, Hutri-Kähönen N, Laitinen T, Lehtimäki T, Viikari JS, Hartiala J, Juonala M, Raitakari OT
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Cumulative Effect of Psychosocial Factors in Youth on Ideal Cardiovascular Health in Adulthood The Cardiovascular Risk in Young Finns Study (2015)
- Circulation
Pulkki-Raback L, Elovainio M, Hakulinen C, Lipsanen J, Hintsanen M, Jokela M, Kubzansky LD, Hintsa T, Serlachius A, Laitinen T, Pahkala K, Mikkila V, Nevalainen J, Hutri-Kahonen N, Juonala M, Viikari J, Raitakari OT, Keltikangas-Jarvinen L
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans (2015)
- Arteriosclerosis, Thrombosis, and Vascular Biology
Rinne P, Ahola-Olli A, Nuutinen S, Koskinen E, Kaipio K, Eerola K, Juonala M, Kahonen M, Lehtimaki T, Raitakari OT, Savontaus E
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Determinants of serum 25(OH)D concentration in young and middle-aged adults. The Cardiovascular Risk in Young Finns Study (2015)
- Annals of Medicine
Atte J. W. Voipio, Katja A. Pahkala, Jorma S. A. Viikari, Vera Mikkilä, Costan G. Magnussen, Nina Hutri-Kähönen, Mika Kähönen, Terho Lehtimäki, Satu Männistö, Britt-Marie Loo, Antti Jula, Jukka Marniemi, Markus Juonala, Olli T. Raitakari
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents (2015)
- Diabetes
Qi QB, Downer MK, Kilpelainen TO, Taal HR, Barton SJ, Ntalla I, Standl M, Boraska V, Huikari V, Kiefte-de Jong JC, Korner A, Lakka TA, Liu GF, Magnusson J, Okuda M, Raitakari O, Richmond R, Scott RA, Bailey MES, Scheuermann K, Holloway JW, Inskip H, Isasi CR, Mossavar-Rahmani Y, Jaddoe VWV, Laitinen J, Lindi V, Melen E, Pitsiladis Y, Pitkanen N, Snieder H, Heinrich J, Timpson NJ, Wang T, Yuji H, Zeggini E, Dedoussis GV, Kaplan RC, Wylie-Rosett J, Loos RJF, Hu FB, Qi L
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Directional dominance on stature and cognition in diverse human populations (2015)
- Nature
Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang WH, Okada Y, Stancakova A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S, Guo XQ, Chasman DI, O'Connel JR, Corre T, Nongmaithem SS, Chen Y, Mangino M, Ruggiero D, Michela T, Farmaki AE, Kacprowski T, Bjonnes A, van der Spek A, Wu Y, Giri AK, Yanek LR, Wang LH, Hofer E, Rietveld CA, McLeod O, Cornelis MC, Pattaro C, Verweij N, Baumbach C, Abdellaoui A, Warren HR, Vuckovic D, Mei H, Bouchard C, Perry JRB, Cappellani S, Mirza SS, Benton MC, Broeckel U, Medland SE, Lind P, Malerba G, Drong A, Yengo L, Bielak LF, Zhi DG, van der Most PJ, Shriner D, Magi R, Hemani G, Karaderi T, Wang ZM, Liu T, Demuth I, Zhao JH, Meng WH, Lataniotis L, van der Laan SW, Bradfield JP, Wood AR, Bonnefond A, Ahluwalia TS, Hall L, Salvi E, Yazar S, Carstensen L, de Haan HG, Abney M, Afzal U, Allison MA, Amin N, Asselbergs FW, Bakker SJL, Barr RG, Baumeister SE, Benjamin DJ, Bergmann S, Boerwinkle E, Bottinger EP, Campbell A, Chakravarti A, Chan YL, Chanock SJ, Chen C, Chen YDI, Collins FS, Connell J, Correa A, Cupples LA, Smith GD, Davies G, Dorr M, Ehret G, Ellis SB, Feenstra B, Feitosa MF, Ford I, Fox CS, Frayling TM, Friedrich N, Geller F, Scotland G, Gillham-Nasenya I, Gottesman O, Graff M, Grodstein F, Gu C, Haley C, Hammond CJ, Harris SE, Harris TB, Hastie ND, Heard-Costa NL, Heikkila K, Hocking LJ, Homuth G, Hottenga JJ, Huang JY, Huffman JE, Hysi PG, Ikram MA, Ingelsson E, Joensuu A, Johansson A, Jousilahti P, Jukema JW, Kahonen M, Kamatani Y, Kanoni S, Kerr SM, Khan NM, Koellinger P, Koistinen HA, Kooner MK, Kubo M, Kuusisto J, Lahti J, Launer LJ, Lea RA, Lehne B, Lehtimaki T, Liewald DCM, Lind L, Loh M, Lokki ML, London SJ, Loomis SJ, Loukola A, Lu YC, Lumley T, Lundqvist A, Mannisto S, Marques-Vidal P, Masciullo C, Matchan A, Mathias RA, Matsuda K, Meigs JB, Meisinger C, Meitinger T, Menni C, Mentch FD, Mihailov E, Milani L, Montasser ME, Montgomery G, Morrison A, Myers RH, Nadukuru R, Navarro P, Nelis M, Nieminen MS, Nolte IM, O'Connor GT, Ogunniyi A, Padmanabhan S, Palmas WR, Pankow JS, Patarcic I, Pavani F, Peyser PA, Pietilainen K, Poulter N, Prokopenko I, Ralhan S, Redmond P, Rich SS, Rissanen H, Robino A, Rose LM, Rose R, Sala C, Salako B, Salomaa V, Sarin AP, Saxena R, Schmidt H, Scott LJ, Scott WR, Sennblad B, Seshadri S, Sever P, Shrestha S, Smith BH, Smith JA, Soranzo N, Sotoodehnia N, Southam L, Stanton AV, Stathopoulou MG, Strauch K, Strawbridge RJ, Suderman MJ, Tandon N, Tang ST, Taylor KD, Tayo BO, Toglhofer AM, Tomaszewski M, Tsernikova N, Tuomilehto J, Uitterlinden AG, Vaidya D, Vlieg AV, van Setten J, Vasankari T, Vedantam S, Vlachopoulou E, Vozzi D, Vuoksimaa E, Waldenberger M, Ware EB, Wentworth-Shields W, Whitfield JB, Wild S, Willemsen G, Yajnik CS, Yao J, Zaza G, Zhu XF, Salem RM, Melbye M, Bisgaard H, Samani NJ, Cusi D, Mackey DA, Cooper RS, Froguel P, Pasterkamp G, Grant SFA, Hakonarson H, Ferrucci L, Scott RA, Morris AD, Palmer CNA, Dedoussis G, Deloukas P, Bertram L, Lindenberger U, Berndt SI, Lindgren CM, Timpson NJ, Tonjes A, Munroe PB, Sorensen TIA, Rotimi CN, Arnett DK, Oldehinkel AJ, Kardia SLR, Balkau B, Gambaro G, Morris AP, Eriksson JG, Wright MJ, Martin NG, Hunt SC, Starr JM, Deary IJ, Griffiths LR, Tiemeier H, Pirastu N, Kaprio J, Wareham NJ, Peerusse L, Wilson JG, Girotto G, Caulfield MJ, Raitakari O, Boomsma DI, Gieger C, van der Harst P, Hicks AA, Kraft P, Sinisalo J, Knekt P, Johannesson M, Magnusson PKE, Hamsten A, Schmidt R, Borecki IB, Vartiainen E, Becker DM, Bharadwaj D, Mohlke KL, Boehnke M, van Duijn CM, Sanghera DK, Teumer A, Zeggini E, Metspalu A, Gasparini P, Ulivi S, Ober C, Toniolo D, Rudan I, Porteous DJ, Ciullo M, Spector TD, Hayward C, Dupuis J, Loos RJF, Wright AF, Chandak GR, Vollenweider P, Shuldiner AR, Ridker PM, Rotter JI, Sattar N, Gyllensten U, North KE, Pirastu M, Psaty BM, Weir DR, Laakso M, Gudnason V, Takahashi A, Chambers JC, Kooner JS, Strachan DP, Campbell H, Hirschhorn JN, Perola M, Polasek O, Wilson JF
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation (2015)
- PLoS Genetics
Horikoshi M, Magi R, van de Bunt M, Surakka I, Sarin AP, Mahajan A, Marullo L, Thorleifsson G, Hagg S, Hottenga JJ, Ladenvall C, Ried JS, Winkler TW, Willems SM, Pervjakova N, Esko T, Beekman M, Nelson CP, Willenborg C, Wiltshire S, Ferreira T, Fernandez J, Gaulton KJ, Steinthorsdottir V, Hamsten A, Magnusson PKE, Willemsen G, Milaneschi Y, Robertson NR, Groves CJ, Bennett AJ, Lehtimaki T, Viikari JS, Rung J, Lyssenko V, Perola M, Heid IM, Herder C, Grallert H, Muller-Nurasyid M, Roden M, Hypponen E, Isaacs A, van Leeuwen EM, Karssen LC, Mihailov E, Houwing-Duistermaat JJ, de Craen AJM, Deelen J, Havulinna AS, Blades M, Hengstenberg C, Erdmann J, Schunkert H, Kaprio J, Tobin MD, Samani NJ, Lind L, Salomaa V, Lindgren CM, Slagboom PE, Metspalu A, van Duijn CM, Eriksson JG, Peters A, Gieger C, Jula A, Groop L, Raitakari OT, Power C, Penninx BWJH, de Geus E, Smit JH, Boomsma DI, Pedersen NL, Ingelsson E, Thorsteinsdottir U, Stefansson K, Ripatti S, Prokopenko I, McCarthy MI, Morris AP; ENGAGE Consortium
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Distensibility of the Aorta and Carotid Artery and Left Ventricular Mass From Childhood to Early Adulthood. (2015)
- Hypertension
Hanna Mikola, Katja Pahkala, Tapani Rönnemaa, Jorma S.A. Viikari, Harri Niinikoski, Eero Jokinen, Pia Salo, Olli Simell, Markus Juonala, Olli T. Raitakari
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: The Cardiovascular Risk in Young Finns Study (2015)
- Atherosclerosis
Burgner DP, Sabin MA, Magnussen CG, Cheung M, Sun C, Kahonen M, Hutri-Kahonen N, Lehtimaki T, Jokinen E, Laitinen T, Viikari JSA, Raitakari OT, Juonala M
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )