Olli Raitakari
 MD/PhD


olli.raitakari@utu.fi

+358 29 450 2304

Kiinamyllynkatu 10

Turku


ORCID-tunniste: https://orcid.org/0000-0001-9365-3702

Asiantuntijuusalueet
cardiovascular and metabolic diseases; risk factors; vascular epidemiology; genetic epidemiology; epidemiology; dietary intervention; cohort studies; follow-up studies

Biografia

EDUCATION AND DEGREES
 
2001   Docent in Clinical Physiology
1997-1999  Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997   Docent in Epidemiology
1996   Specialist in Clinical Physiology 
1995   Doctorate, PhD
1989   Licentiate in Medicine, MD

CURRENT POSITIONS

2017-                 Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and 
                          Preventive Cardiovascular Medicine, University of Turku, Finland                         

 

PAST POSITIONS

2012-2016                          Academy Professor, University of Turku

2007-2016                          Professor in Cardiovascular Medicine (part time), University of Turku

2007-2008                          Senior Scientist Grant, Academy of Finland

2004-2016                          Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
                                           University Hospital (leave of absence 2012-2016)

2002-2004                          Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital

2002 (1 mo)                        Head of Nuclear Medicine Department, Turku University Hospital

2000-2003 (3 mo)               Head of Clinical Physiology Department, Turku University Hospital

2000-2005                          Senior Fellow Post, Academy of Finland

1998-2000                          Postdoctoral Research Post, Academy of Finland

1996-1997                          Consultant in Clinical Physiology, Turku University Hospital

1991-1996                          Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical 
                                           Physiology, Turku University Hospital

1988-1990                          Positions as General Practioner and Resident in Internal Medicine or Surgery




Tutkimus

Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.



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  • Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants  (2020)  
    • Lancet
     NCD Risk Factor Collaboration (NCD-RisC)
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Ideal cardiovascular health in adolescents and young adults is associated with alexithymia over two decades later: Findings from the cardiovascular risk in Young Finns Study  (2020)  
    • Psychiatry Research
     Karukivi M, Jula A, Pulkki-Råback L, Hutri-Kähönen N, Laitinen TT, Viikari J, Juonala M, Raitakari O
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure  (2020)  
    • Hypertension
     Huang YS, Ollikainen M, Muniandy M, Zhang T, van Dongen J, Hao G, van Der Most PJ, Pan Y, Pervjakova N, Sun YV, Hui Q, Lahti J, Fraszczyk E, Lu XL, Sun D, Richard MA, Willemsen G, Heikkila K, Leach IM, Mononen N, Kahonen M, Hurme MA, Raitakari OT, Drake AJ, Perola M, Nuotio ML, Huang YF, Khulan B, Raikkonen K, Wolffenbuttel BHR, Zhernakova A, Fu JY, Zhu HD, Dong YB, van Vliet-Ostaptchouk JV, Franke L, Eriksson JG, Fornage M, Milani L, Lehtimaki T, Vaccarino V, Boomsma DI, van Der Harst P, de Geus EJC, Salomaa V, Li SX, Chen W, Su SY, Wilson J, Snieder H, Kaprio J, Wang XL
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Increase in adiposity from childhood to adulthood predicts a metabolically obese phenotype in normal-weight adults  (2020)  
    • International Journal of Obesity
     A. Viitasalo, N. Pitkänen, K. Pahkala, T. Lehtimäki, J. S. A. Viikari, O. Raitakari, T. O. Kilpeläinen
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke  (2020)  
    • Hypertension
     Matthew Traylor , Ali Amin Al Olama, Leo-Pekka Lyytikäinen, Sandro Marini, Jaeyoon Chung, Rainer Malik, Martin Dichgans, Mika Kähönen, Terho Lehtimäki, Christopher D. Anderson, Olli T. Raitakari, Hugh S. Markus
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study  (2020)  
    • BONE
     Binisha H. Mishra, Pashupati P. Mishra, Nina Mononen, Mika Hilvo, Harri Sievänen, Markus Juonala, Marika Laaksonen, Nina Hutri-Kähönen, Jorma Viikari, Mika Kähönen, Olli T.Raitakari, Reijo Laaksonen, Terho Lehtimäki
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Longitudinal association of a body mass index (BMI) genetic risk score with growth and BMI changes across the life course: The Cardiovascular Risk in Young Finns Study  (2020)  
    • International Journal of Obesity
     Buscot MJ, Wu FT, Juonala M, Lehtimaki T, Pitkanen N, Sabin MA, Viikari JSA, Raitakari OT, Magnussen CG
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood  (2020)  
    • European Journal of Epidemiology
     Zheng Y., Huang T., Wang T., Mei Z., Sun Z., Zhang T., Ellervik C., Chai J.-F., Sim X., van Dam R.M., Tai E.-S., Koh W.-P., Dorajoo R., Saw S.-M., Sabanayagam C., Wong T.Y., Gupta P., Rossing P., Ahluwalia T.S., Vinding R.K., Bisgaard H., Bønnelykke K., Wang Y., Graff M., Voortman T., van Rooij F.J.A., Hofman A., van Heemst D., Noordam R., Estampador A.C., Varga T.V., Enzenbach C., Scholz M., Thiery J., Burkhardt R., Orho-Melander M., Schulz C.-A., Ericson U., Sonestedt E., Kubo M., Akiyama M., Zhou A., Kilpeläinen T.O., Hansen T., Kleber M.E., Delgado G., McCarthy M., Lemaitre R.N., Felix J.F., Jaddoe V.W.V., Wu Y., Mohlke K.L., Lehtimäki T., Wang C.A., Pennell C.E., Schunkert H., Kessler T., Zeng L., Willenborg C., Peters A., Lieb W., Grote V., Rzehak P., Koletzko B., Erdmann J., Munz M., Wu T., He M., Yu C., Lecoeur C., Froguel P., Corella D., Moreno L.A., Lai C.-Q., Pitkänen N., Boreham C.A., Ridker P.M., Rosendaal F.R., de Mutsert R., Power C., Paternoster L., Sørensen T.I.A., Tjønneland A., Overvad K., Djousse L., Rivadeneira F., Lee N.R., Raitakari O.T., Kähönen M., Viikari J., Langhendries J.-P., Escribano J., Verduci E., Dedoussis G., König I., Balkau B., Coltell O., Dallongeville J., Meirhaeghe A., Amouyel P., Gottrand F., Pahkala K., Niinikoski H., Hyppönen E., März W., Mackey D.A., Gruszfeld D., Tucker K.L., Fumeron F., Estruch R., Ordovas J.M., Arnett D.K., Mook-Kanamori D.O., Mozaffarian D., Psaty B.M., North K.E., Chasman D.I., Qi L.
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction  (2020)  
    • Nature Communications
     Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP, Souza RP, Tarazona-Santos E, Giedraitis V, Ingelsson E, Mahajan A, Morris AP, Del Greco M F, Foco L, Gögele M, Hicks AA, Cook JP, Lind L, Lindgren CM, Sundström J, Nelson CP, Riaz MB, Samani NJ, Sinagra G, Ulivi S, Kähönen M, Mishra PP, Mononen N, Nikus K, Caulfield MJ, Dominiczak A, Padmanabhan S, Montasser ME, O'Connell JR, Ryan K, Shuldiner AR, Aeschbacher S, Conen D, Risch L, Thériault S, Hutri-Kähönen N, Lehtimäki T, Lyytikäinen LP, Raitakari OT, Barnes CLK, Campbell H, Joshi PK, Wilson JF, Isaacs A, Kors JA, van Duijn CM, Huang PL, Gudnason V, Harris TB, Launer LJ, Smith AV, Bottinger EP, Loos RJF, Nadkarni GN, Preuss MH, Correa A, Mei H, Wilson J, Meitinger T, Müller-Nurasyid M, Peters A, Waldenberger M, Mangino M, Spector TD, Rienstra M, van de Vegte YJ, van der Harst P, Verweij N, Kääb S, Schramm K, Sinner MF, Strauch K, Cutler MJ, Fatkin D, London B, Olesen M, Roden DM, Benjamin Shoemaker M, Gustav Smith J, Biggs ML, Bis JC, Brody JA, Psaty BM, Rice K, Sotoodehnia N, De Grandi A, Fuchsberger C, Pattaro C, Pramstaller PP, Ford I, Wouter Jukema J, Macfarlane PW, Trompet S, Dörr M, Felix SB, Völker U, Weiss S, Havulinna AS, Jula A, Sääksjärvi K, Salomaa V, Guo X, Heckbert SR, Lin HJ, Rotter JI, Taylor KD, Yao J, de Mutsert R, Maan AC, Mook-Kanamori DO, Noordam R, Cucca F, Ding J, Lakatta EG, Qian Y, Tarasov KV, Levy D, Lin H, Newton-Cheh CH, Lunetta KL, Murray AD, Porteous DJ, Smith BH, Stricker BH, Uitterlinden A, van den Berg ME, Haessler J, Jackson RD, Kooperberg C, Peters U, Reiner AP, Whitsel EA, Alonso A, Arking DE, Boerwinkle E, Ehret GB, Soliman EZ, Avery CL, Gogarten SM, Kerr KF, Laurie CC, Seyerle AA, Stilp A, Assa S, Abdullah Said M, Yldau van der Ende M, Lambiase PD, Orini M, Ramirez J, Van Duijvenboden S, Arnar DO, Gudbjartsson DF, Holm H, Sulem P, Thorleifsson G, Thorolfsdottir RB, Thorsteinsdottir U, Benjamin EJ, Tinker A, Stefansson K, Ellinor PT, Jamshidi Y, Lubitz SA, Munroe PB
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries  (2020)  
    • International Journal of Epidemiology
     NCD Risk Factor Collaboration (NCD-RisC)
    (    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )



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