Olli Raitakari
MD/PhD
olli.raitakari@utu.fi +358 29 450 2304 Kiinamyllynkatu 10 Turku ORCID-tunniste: https://orcid.org/0000-0001-9365-3702 |
cardiovascular and metabolic diseases; risk factors; vascular epidemiology; genetic epidemiology; epidemiology; dietary intervention; cohort studies; follow-up studies
EDUCATION AND DEGREES
2001 Docent in Clinical Physiology
1997-1999 Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997 Docent in Epidemiology
1996 Specialist in Clinical Physiology
1995 Doctorate, PhD
1989 Licentiate in Medicine, MD
CURRENT POSITIONS
2017- Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and
Preventive Cardiovascular Medicine, University of Turku, Finland
PAST POSITIONS
2012-2016 Academy Professor, University of Turku
2007-2016 Professor in Cardiovascular Medicine (part time), University of Turku
2007-2008 Senior Scientist Grant, Academy of Finland
2004-2016 Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
University Hospital (leave of absence 2012-2016)
2002-2004 Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital
2002 (1 mo) Head of Nuclear Medicine Department, Turku University Hospital
2000-2003 (3 mo) Head of Clinical Physiology Department, Turku University Hospital
2000-2005 Senior Fellow Post, Academy of Finland
1998-2000 Postdoctoral Research Post, Academy of Finland
1996-1997 Consultant in Clinical Physiology, Turku University Hospital
1991-1996 Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical
Physiology, Turku University Hospital
1988-1990 Positions as General Practioner and Resident in Internal Medicine or Surgery
Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.
- Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants (2016)
- Lancet
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - TV viewing and subclinical cardiac diastolic dysfunction in early midlife. The Cardiovascular Risk in Young Finns Study. (2016) Helajärvi H, Ruohonen S, Pahkala K, Heinonen OJ, Viikari J, Raitakari OT
(O2 Muu julkaisu ) - Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram (2016)
- Human Molecular Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis (2016)
- American Journal of Human Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants (2016)
- Lancet
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Activated immune-inflammatory pathways are associated with long-standing depressive symptoms: Evidence from gene-set enrichment analyses in the Young Finns Study (2015)
- Journal of Psychiatric Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Adolescence physical activity is associated with higher tibial pQCT bone values in adulthood after 28-years of follow-up The Cardiovascular Risk in Young Finns Study (2015)
- BONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Adult dyslipidemia prediction is improved by repeated measurements in childhood and young adulthood. The Cardiovascular Risk in Young Finns Study (2015)
- Atherosclerosis
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Adulthood temperament and educational attainment: A population-based cohort study (2015)
- Learning and Instruction
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism (2015)
- PLoS Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure (2015)
- Human Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A novel common variant in DCST2 is associated with length in early life and height in adulthood (2015)
- Human Molecular Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Association of adiponectin with adolescent cardiovascular health in a dietary intervention study (2015)
- Journal of Pediatrics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Biological interpretation of genome-wide association studies using predicted gene functions (2015)
- Nature Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Childhood 25-OH Vitamin D Levels and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study (2015)
- Journal of Clinical Endocrinology and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Childhood and adolescence risk factors and development of depressive symptoms: the 32-year prospective Young Finns follow-up study (2015)
- Journal of Epidemiology and Community Health
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies (2015)
- Cephalalgia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians (2015)
- American Journal of Clinical Nutrition
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Coronary heart disease risk factors, coronary artery calcification and epicardial fat volume in the Young Finns Study (2015)
- EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Cumulative Effect of Psychosocial Factors in Youth on Ideal Cardiovascular Health in Adulthood The Cardiovascular Risk in Young Finns Study (2015)
- Circulation
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )