MD/PhD Olli Raitakari - UTU Research Portal

Olli Raitakari
MD/PhD

- Professor,
Cardiovascular Medicine (CAPC) (Centre for Population Health Research (POP Centre))
- ,
InFLAMES Flagship (Faculty of Medicine)

olli.raitakari@utu.fi

+358 29 450 2304

Kiinamyllynkatu 10

Turku

ORCID identifier: https://orcid.org/0000-0001-9365-3702

10_representative_publications.pdf

Areas of expertise

cardiovascular and metabolic diseases; risk factors; vascular epidemiology; genetic epidemiology; epidemiology; dietary intervention; cohort studies; follow-up studies

Biography

EDUCATION AND DEGREES

2001   Docent in Clinical Physiology
1997-1999  Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997   Docent in Epidemiology
1996   Specialist in Clinical Physiology
1995   Doctorate, PhD
1989   Licentiate in Medicine, MD

CURRENT POSITIONS

2017- Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and
Preventive Cardiovascular Medicine, University of Turku, Finland

PAST POSITIONS

2012-2016 Academy Professor, University of Turku

2007-2016 Professor in Cardiovascular Medicine (part time), University of Turku

2007-2008 Senior Scientist Grant, Academy of Finland

2004-2016 Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
University Hospital (leave of absence 2012-2016)

2002-2004 Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital

2002 (1 mo) Head of Nuclear Medicine Department, Turku University Hospital

2000-2003 (3 mo) Head of Clinical Physiology Department, Turku University Hospital

2000-2005 Senior Fellow Post, Academy of Finland

1998-2000 Postdoctoral Research Post, Academy of Finland

1996-1997 Consultant in Clinical Physiology, Turku University Hospital

1991-1996 Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical
Physiology, Turku University Hospital

1988-1990 Positions as General Practioner and Resident in Internal Medicine or Surgery

Research

Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.

Publications

23 of 52

Effect of Dietary Counseling on a Comprehensive Metabolic Profile from Childhood to Adulthood (2018)
- Journal of Pediatrics
Miia Lehtovirta, Katja Pahkala, Harri Niinikoski, Antti J. Kangas, Pasi Soininen, Hanna Lagström, Jorma S.A. Viikari, Tapani Rönnemaa, Antti Jula, Mika Ala-Korpela, Peter Würtz, Olli T. Raitakari
(A1 Refereed original research article in a scientific journal)
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 (2018)
- Genome Biology
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu XQ, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao RF, Lin HH, Liu CT, Lyytikainen LP, Marten J, Mei H, Muller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F, Ramirez J, Robino A, Schwartz M, van Setten J, Smith AV, Verweij N, Warren HR, Weiss S, Alonso A, Arnar DO, Bots ML, de Boer RA, Dominiczak AF, Eijgelsheim M, Ellinor PT, Guo XQ, Felix SB, Harris TB, Hayward C, Heckbert SR, Huang PL, Jukema JW, Kahonen M, Kors JA, Lambiase PD, Launer LJ, Li M, Linneberg A, Nelson CP, Pedersen O, Perez M, Peters A, Polasek O, Psaty BM, Raitakari OT, Rice KM, Rotter JI, Sinner MF, Soliman EZ, Spector TD, Strauch K, Thorsteinsdottir U, Tinker A, Trompet S, Uitterlinden A, Vaartjes I, van der Meer P, Volker U, Volzke H, Waldenberger M, Wilson JG, Xie ZJ, Asselbergs FW, Dorr M, van Duijn CM, Gasparini P, Gudbjartsson DF, Gudnason V, Hansen T, Kaab S, Kanters JK, Kooperberg C, Lehtimaki T, Lin HJ, Lubitz SA, Mook-Kanamori DO, Conti FJ, Newton-Cheh CH, Rosand J, Rudan I, Samani NJ, Sinagra G, Smith BH, Holm H, Stricker BH, Ulivi S, Sotoodehnia N, Apte SS, van der Harst P, Stefansson K, Munroe PB, Arking DE, Lo CW, Jamshidi Y, Jamshidi Y
(A1 Refereed original research article in a scientific journal)
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals (2018)
- Circulation: Genomic and Precision Medicine
Nathan A. Bihlmeyer, Jennifer A. Brody, Albert Vernon Smith, Helen R. Warren, Honghuang Lin, Aaron Isaacs, Ching-Ti Liu, Jonathan Marten, Farid Radmanesh, Leanne M. Hall, Niels Grarup, Hao Mei, Martina Müller-Nurasyid, Jennifer E. Huffman, Niek Verweij, Xiuqing Guo, Jie Yao, Ruifang Li-Gao, Marten van den Berg, Stefan Weiss, Bram P. Prins, Jessica van Setten, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Man Li, Alvaro Alonso, Elsayed Z. Soliman, Joshua C. Bis, Tom Austin, Yii-Der Ida Chen, Bruce M. Psaty, Tamara B. Harrris, Lenore J. Launer, Sandosh Padmanabhan, Anna Dominiczak, Paul L. Huang, Zhijun Xie, Patrick T. Ellinor, Jan A. Kors, Archie Campbell, Alison D. Murray, Christopher P. Nelson, Martin D. Tobin, Jette Bork-Jensen, Torben Hansen, Oluf Pedersen, Allan Linneberg, Moritz F. Sinner, Annette Peters, Melanie Waldenberger, Thomas Meitinger, Siegfried Perz, Ivana Kolcic, Igor Rudan, Rudolf A. de Boer, Peter van der Meer, Henry J. Lin, Kent D. Taylor, Renée de Mutsert, Stella Trompet, J. Wouter Jukema, Arie C. Maan, Bruno H.C. Stricker, Fernando Rivadeneira, André Uitterlinden, Uwe Völker, Georg Homuth, Henry Völzke, Stephan B. Felix, Massimo Mangino, Timothy D. Spector, Michiel L. Bots, Marco Perez, Olli T. Raitakari, Mika Kähönen, Nina Mononen, Vilmundur Gudnason, Patricia B. Munroe, Steven A. Lubitz, Cornelia M. van Duijn, Christopher H. Newton-Cheh, Caroline Hayward, Jonathan Rosand, Nilesh J. Samani, Jørgen K. Kanters, James G. Wilson, Stefan Kääb, Ozren Polasek, Pim van der Harst, Susan R. Heckbert, Jerome I. Rotter, Dennis O. Mook-Kanamori, Mark Eijgelsheim, Marcus Dörr, Yalda Jamshidi, Folkert W. Asselbergs, Charles Kooperberg, Terho Lehtimäki, Dan E. Arking, Nona Sotoodehnia
(A1 Refereed original research article in a scientific journal)
Fatty liver is associated with blood pathways of inflammatory response, immune system activation and prothrombotic state in Young Finns Study (2018)
- Scientific Reports
Tuukka Taipale, Ilkka Seppälä, Emma Raitoharju, Nina Mononen, Leo-Pekka Lyytikäinen, Thomas Illig, Melanie Waldenberger, Markus Juonala, Nina Hutri-Kähönen, Niku Oksala, Mika Kähönen, Olli Raitakari, Terho Lehtimäki
(A1 Refereed original research article in a scientific journal)
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals (2018)
- Nature Genetics
James J. Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, Julia Sidorenko, Richard Karlsson Linnér, Mark Alan Fontana, Tushar Kundu, Chanwook Lee, Hui Li, Ruoxi Li, Rebecca Royer, Pascal N. Timshel, Raymond K. Walters, Emily A. Willoughby, Loïc Yengo, 23andMe Research Team; COGENT (Cognitive Genomics Consortium); Social Science Genetic Association Consortium, Maris Alver, Yanchun Bao, David W. Clark, Felix R. Day, Nicholas A. Furlotte, Peter K. Joshi, Kathryn E. Kemper, Aaron Kleinman, Claudia Langenberg, Reedik Mägi, Joey W. Trampush, Shefali Setia Verma, Yang Wu, Max Lam, Jing Hua Zhao, Zhili Zheng, Jason D. Boardman, Harry Campbell, Jeremy Freese, Kathleen Mullan Harris, Caroline Hayward, Pamela Herd, Meena Kumari, Todd Lencz, Jian’an Luan, Anil K. Malhotra, Andres Metspalu, Lili Milani, Ken K. Ong, John R. B. Perry, David J. Porteous, Marylyn D. Ritchie, Melissa C. Smart, Blair H. Smith, Joyce Y. Tung, Nicholas J. Wareham, James F. Wilson, Jonathan P. Beauchamp, Dalton C. Conley, Tõnu Esko, Steven F. Lehrer, Patrik K. E. Magnusson, Sven Oskarsson, Tune H. Pers, Matthew R. Robinson, Kevin Thom, Chelsea Watson, Christopher F. Chabris, Michelle N. Meyer, David I. Laibson, Jian Yang, Magnus Johannesson, Philipp D. Koellinger, Patrick Turley, Peter M. Visscher, Daniel J. Benjamin, David Cesarini;
(A1 Refereed original research article in a scientific journal)
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018)
- Nature Genetics
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsu B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrer CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Edwards DRV, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Magi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan JA, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Theriault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Pare G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco MF, Demirkale CY, Dorr M, Ehret GB, Elosua R, Enroth S, Erzurumluoglu AM, Ferreira T, Franberg M, Franco OH, Gandin I, Gasparini P, Giedraitis V, Gieger C, Girotto G, Goel A, Gow AJ, Gudnason V, Guo XQ, Gyllensten U, Hamsten A, Harris TB, Harris SE, Hartman CA, Havulinna AS, Hicks AA, Hofer E, Hofman A, Hottenga JJ, Huffman JE, Hwang SJ, Ingelsson E, James A, Jansen R, Jarvelin MR, Joehanes R, Johansson A, Johnson AD, Joshi PK, Jousilahti P, Jukema JW, Jula A, Kahonen M, Kathiresan S, Keavney BD, Khaw KT, Knekt P, Knight J, Kolcic I, Kooner JS, Koskinen S, Kristiansson K, Kutalik Z, Laan M, Larson M, Launer LJ, Lehne B, Lehtimaki T, Liewald DCM, Lin L, Lind L, Lindgren CM, Liu YM, Loos RJF, Lopez LM, Lu YC, Lyytikainen LP, Mahajan A, Mamasoula C, Marrugat J, Marten J, Milaneschi Y, Morgan A, Morris AP, Morrison AC, Munson PJ, Nalls MA, Nandakumar P, Nelson CP, Niiranen T, Nolte IM, Nutile T, Oldehinkel AJ, Oostra BA, O'Reilly PF, Org E, Padmanabhan S, Palmas W, Palotie A, Pattie A, Penninx BWJH, Perola M, Peters A, Polasek O, Pramstaller PP, Nguyen QT, Raitakari OT, Ren M, Rettig R, Rice K, Ridker PM, Ried JS, Riese H, Ripatti S, Robino A, Rose LM, Rotter JI, Rudan I, Ruggiero D, Saba Y, Sala CF, Salomaa V, Samani NJ, Sarin AP, Schmidt R, Schmidt H, Shrine N, Siscovick D, Smith AV, Snieder H, Sober S, Sorice R, Starr JM, Stott DJ, Strachan DP, Strawbridge RJ, Sundstrom J, Swertz MA, Taylor KD, Teumer A, Tobin MD, Tomaszewski M, Toniolo D, Traglia M, Trompet S, Tuomilehto J, Tzourio C, Uitterlinden AG, Vaez A, van der Most PJ, van Duijn CM, Vergnaud AC, Verwoert GC, Vitart V, Volker U, Vollenweider P, Vuckovic D, Watkins H, Wild SH, Willemsen G, Wilson JF, Wright AF, Yao J, Zemunik T, Zhang WH, Attia JR, Butterworth AS, Chasman D, Conen D, Cucca F, Danesh J, Hayward C, Howson JMM, Laakso M, Lakatta EG, Langenberg C, Melander O, Mook-Kanamori DO, Palmer CNA, Risch L, Scott RA, Scott RJ, Sever P, Spector TD, van der Harst P, Wareham NJ, Zeggini E, Levy D, Munroe PB, Newton-Cheh C, Brown MJ, Metspalu A, Hung AM, O'Donnell C, Edwards TL, Psaty BM, Tzoulaki I, Barnes MR, Wain LV, Elliott P, Caulfield MJ, Psaty BM, Edwards TL, O'Donnell C, Hung AM, Elliott P, Wain LV, Barnes MR, Tzoulaki I, Caulfield MJ, Brown MJ, Metspalu A
(A1 Refereed original research article in a scientific journal)
Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
Gertraud Erhart, Claudia Lamina, Terho Lehtimäki, Pedro Marques-Vidal, Mika Kähönen, Peter Vollenweider, Olli T. Raitakari, Gérard Waeber, Barbara Thorand, Konstantin Strauch, Christian Gieger, Thomas Meitinger, Annette Peters, Florian Kronenberg, Stefan Coassin
(A1 Refereed original research article in a scientific journal)
Genetic polymorphism of sterol transporters in children with future gallstones (2018)
- Digestive and Liver Disease
Markku J.Nissinen, Niina Pitkänen, Piia Simonen, Helena Gylling, Jorma Viikari, Olli Raitakari, Terho Lehtimäki, Markus Juonala, Mikko P. Pakarinen
(A1 Refereed original research article in a scientific journal)
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders (2018)
- American Journal of Human Genetics
Ligthart S, Vaez A, Vosa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin HH, Pool R, Zhu G, Mace A, Sidore C, Trompet S, Mangino M, Sabater-Lleal M, Kemp JP, Abbasi A, Kacprowski T, Verweij N, Smith AV, Huang T, Marzi C, Feitosa MF, Lohman KK, Kleber ME, Milaneschi Y, Mueller C, Huq M, Vlachopoulou E, Lyytikainen LP, Oldmeadow C, Deelen J, Perola M, Zhao JH, Feenstra B, Amini M, Lahti J, Schraut KE, Fornage M, Suktitipat B, Chen WM, Li XH, Nutile T, Malerba G, Luan JA, Bak T, Schork N, Del Greco MF, Thiering E, Mahajan A, Marioni RE, Mihailov E, Eriksson J, Ozel AB, Zhang WH, Nethander M, Cheng YC, Aslibekyan S, Ang W, Gandin I, Yengo L, Portas L, Kooperberg C, Hofer E, Rajan KB, Schurmann C, den Hollander W, Ahluwalia TS, Zhao J, Draisma HHM, Ford I, Timpson N, Teumer A, Huang HY, Wahl S, Liu YM, Huang J, Uh HW, Geller F, Joshi PK, Yanek LR, Trabetti E, Lehne B, Vozzi D, Verbanck M, Biino G, Saba Y, Meulenbelt I, O'Connell JR, Laakso M, Giulianini F, Magnusson PKE, Ballantyne CM, Hottenga JJ, Montgomery G, Rivadineira F, Rueedi R, Steri M, Herzig KH, Stott DJ, Menni C, Franberg M, St Pourcain B, Felix SB, Pers TH, Bakker SJL, Kraft P, Peters A, Vaidya D, Delgado G, Smit JH, Grossmann V, Sinisalo J, Seppala I, Williams SR, Holliday EG, Moed M, Langenberg C, Raikkonen K, Ding JZ, Campbell H, Sale MM, Chen YDI, James AL, Ruggiero D, Soranzo N, Hartman CA, Smith EN, Berenson GS, Fuchsberger C, Hernandez D, Tiesler CMT, Giedraitis V, Liewald D, Fischer K, Mellstrom D, Larsson A, Wang YM, Scott WR, Lorentzon M, Beilby J, Ryan KA, Pennell CE, Vuckovic D, Balkau B, Concas MP, Schmidt R, de Leon CFM, Bottinger EP, Kloppenburg M, Paternoster L, Boehnke M, Musk AW, Willemsen G, Evans DM, Madden PAF, Kahonen M, Kutalik Z, Zoledziewska M, Karhunen V, Kritchevsky SB, Sattar N, Lachance G, Clarke R, Harris TB, Raitakari OT, Attia JR, Van Heemst D, Kajantie E, Sorice R, Gambaro G, Scott RA, Hicks AA, Ferrucci L, Standl M, Lindgren CM, Starr JM, Karlsson M, Lind L, Li JZ, Chambers JC, Mori TA, de Geus EJCN, Heath AC, Martin NG, Auvinen J, Buckley BM, de Craen AJM, Waldenberger M, Strauch K, Meitinger T, Scott RJ, McEvoy M, Beekman M, Bombieri C, Ridker PM, Mohlke KL, Pedersen NL, Morrison AC, Boomsma DI, Whitfield JB, Strachan DP, Hofman A, Vollenweider P, Cucca F, Jarvelin MR, Jukema JW, Spector TD, Hamsten A, Zeller T, Uitterlinden AG, Nauck M, Gudnason V, Qi L, Grallert H, Borecki IB, Rotter JI, Marz W, Wild PS, Lokki ML, Boyle M, Salomaa V, Melbye M, Eriksson JG, Wilson JF, Penninx BWJH, Becker DM, Worrall BB, Gibson G, Krauss RM, Ciullo M, Zaza G, Wareham NJ, Oldehinkel AJ, Palmer LJ, Murray SS, Pramstaller PP, Bandinelli S, Heinrich J, Ingelsson E, Deary IJ, Magi R, Vandenput L, van der Harst P, Desch KC, Kooner JS, Ohlsson C, Hayward C, Lehtimaki T, Shuldiner AR, Arnett DK, Beilin LJ, Robino A, Froguel P, Pirastu M, Jess T, Koenig W, Loos RJF, Evans DA, Schmidt H, Smith GD, Slagboom PE, Eiriksdottir G, Morris AP, Psaty BM, Tracy RP, Nolte IM, Boerwinkle E, Visvikis-Siest S, Reiner AP, Gross M, Bis JC, Franke L, Franco OH, Benjamin EJ, Chasman DI, Dupuis J, Snieder H, Dehghan A, Alizadeh BZ
(A1 Refereed original research article in a scientific journal)
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes (2018)
- Nature Communications
Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E. Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu; eQTLGen Consortium, Allan F. McRae, Peter M. Visscher, Jian Zeng & Jian Yang
(A1 Refereed original research article in a scientific journal)
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error (2018)
- Nature Genetics
Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, Iglesias AI, Meester-Smoor MA, Tompson SW, Fan Q, Khawaja AP, Cheng CY, Hohn R, Yamashiro K, Wenocur A, Grazal C, Haller T, Metspalu A, Wedenoja J, Jonas JB, Wang YX, Xie J, Mitchell P, Foster PJ, Klein BEK, Klein R, Paterson AD, Hosseini SM, Shah RL, Williams C, Teo YY, Tham YC, Gupta P, Zhao WT, Shi Y, Saw WY, Tai ES, Sim XL, Huffman JE, Polasek O, Hayward C, Bencic G, Rudan I, Wilson JF, Joshi PK, Tsujikawa A, Matsuda F, Whisenhunt KN, Zeller T, van der Spek PJ, Haak R, Meijers-Heijboer H, van Leeuwen EM, Iyengar SK, Lass JH, Hofman A, Rivadeneira F, Uitterlinden AG, Vingerling JR, Lehtimaki T, Raitakari OT, Biino G, Concas MP, Schwantes-An TH, Igo RP, Cuellar-Partida G, Martin NG, Craig JE, Gharahkhani P, Williams KM, Nag A, Rahi JS, Cumberland PM, Delcourt C, Bellenguez C, Ried JS, Bergen AA, Meitinger T, Gieger C, Wong TY, Hewitt AW, Mackey DA, Simpson CL, Pfeiffer N, Parssinen O, Baird PN, Vitart V, Amin N, van Duijn CM, Bailey-Wilson JE, Young TL, Saw SM, Stambolian D, MacGregor S, Guggenheim JA, Tung JY, Hammond CJ, Klaver CCW
(A1 Refereed original research article in a scientific journal)
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels (2018)
- Nature Communications
Joshi P., Cavadino A., Hayward C., Wilson J., Michaëlsson K., Lind L., Zillikens M., Trompet S., De Boer I., März W., Rotter J., Wood A., Robinson-Cohen C., Rich S., Jarvelin M., Den Heijer M., Dunlop M., Valdes A., Tikkanen E., Lehtimäki T., Lyytikäinen L., Kähönen M., Raitakari O., Mikkilä V., Uitterlinden A., Rivadeneira F., Broer L., Zgaga L., Campbell H., Theodoratou E., Farrington S., Timofeeva M., Wang T., Spector T., Danesh J., Butterworth A., Kiel D., Kraft P., Hyppönen E., Wareham N., Jukema J., Sattar N., Ikram M., Khaw K., Gundersen T., Forouhi N., Langenberg C., Jiang X., Dupuis J., Ingelsson E., Karasik D., Pilz S., O'Reilly P., Aschard H., Hsu Y., Richards J., Streeten E., Sofianopoulou E., Lutsey P., Albanes D., Kestenbaum B., Berry D., Luan J., Zheng J., Zhou A., Völzke H., McCarthy M., Power C., Tang W., Yao L., Wallaschofski H., Econs M., Van Der Velde N., Groot L., Huang W., Van Schoor N., Weinstein S., Freedman N., Michos E., Boerwinkle E., Ripatti S., Ohlsson C., Liu C., Zhou Y., Booth S., Vasan R., Enneman A., Cupples L., Lohman K., Liu Y., Kritchevsky S., Houston D., Shea M., Eriksson J., Lorentzon M., Vandenput L., Kleber M., Heemst D., Deelen J., Slagboom E., Beekman M., Gieger C., Peacock M., Ferrucci L.
(A1 Refereed original research article in a scientific journal)
Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent (2018)
- Molecular Nutrition and Food Research
Smith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM, Kilpelainen TO, Wojczynski MK, Richardson K, Nalls MA, Schulz CA, Liu YM, Frazier-Wood AC, van Eekelen E, Wang C, de Vries PS, Mikkilä V, Rohde R, Psaty BM, Hansen T, Feitosa MF, Lai CQ, Houston DK, Ferruci L, Ericson U, Wang Z, de Mutsert R, Oddy WH, de Jonge EAL, Seppälä I, Justice AE, Lemaitre RN, Sørensen TIA, Province MA, Parnell LD, Garcia ME, Bandinelli S, Orho-Melander M, Rich SS, Rosendaal FR, Pennell CE, Kiefte-de Jong JC, Kähönen M, Young KL, Pedersen O, Aslibekyan S, Rotter JI, Mook-Kanamori DO, Zillikens MC, Raitakari OT, North KE, Overvad K, Arnett DK, Hofman A, Lehtimaki T, Tjønneland A, Uitterlinden AG, Rivadeneira F, Franco OH, German JB, Siscovick DS, Cupples LA, Ordovás JM
(A1 Refereed original research article in a scientific journal)
Geographic origin as a determinant of left ventricular mass and diastolic function – the Cardiovascular Risk in Young Finns Study (2018)
- Scandinavian Journal of Public Health
L. Vähämurto, M. Juonala, S. Ruohonen, N. Hutri-Kähönen, M. Kähönen, T. Laitinen, P. Tossavainen, E. Jokinen, J. Viikari, O.T. Raitakari, K. Pahkala
(A1 Refereed original research article in a scientific journal)
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes (2018)
- Nature Communications
Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu LY, Scholz M, Sargurupremraj M, Pitkanen N, Franzen O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Volzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang JJ, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dorr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hagg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimaki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu XF, Zhang XL, Guo XQ, Saba Y, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikainen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Volker U, Gudnason V, Hingorani AD, Bjorkegren JLM, Casas JP, O'Donnell CJ, Humphries SE, Volker U, Gudnason V, Hingorani AD, Bjorkegren JLM, Casas JP, O'Donnell CJ
(A1 Refereed original research article in a scientific journal)
Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants (2018)
- Scientific Reports
Zhou A, Taylor AE, Karhunen V, Zhan YQ, Rovio SP, Lahti J, Sjogren P, Byberg L, Lyall DM, Auvinen J, Lehtimaki T, Kahonen M, Hutri-Kahonen N, Perala MM, Michaelsson K, Mahajan A, Lind L, Power C, Eriksson JG, Raitakari OT, Hagg S, Pedersen NL, Veijola J, Jarvelin MR, Munafo MR, Ingelsson E, Llewellyn DJ, Hypponen E
(A1 Refereed original research article in a scientific journal)
Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland (2018)
- American Journal of Human Genetics
Martin AR, Karczewski KJ, Kerminen S, Kurki MI, Sarin AP, Artomov M, Eriksson JG, Esko T, Genovese G, Havulinna AS, Kaprio J, Konradi A, Koranyi L, Kostareva A, Mannikko M, Metspalu A, Perola M, Prasad RB, Raitakari O, Rotar O, Salomaa V, Groop L, Palotie A, Neale BM, Ripatti S, Pirinen M, Daly MJ, Daly MJ
(A1 Refereed original research article in a scientific journal)
Higher step count is associated with greater bone mass and strength in women but not in men (2018)
- Archives of Osteoporosis
Sanna Tolonen, Harri Sievänen, Mirja Hirvensalo, Marika Laaksonen, Vera Mikkilä, Kristiina Pälve, Terho Lehtimäki, Olli Raitakari, Mika Kähönen
(A1 Refereed original research article in a scientific journal)
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood (2018)
- Nature Communications
Qi T, Wu Y, Zeng J, Zhang FT, Xue AL, Jiang LD, Zhu ZH, Kemper K, Yengo L, Zheng ZL; eQTLGen Consortium, Marioni RE, Montgomery GW, Deary IJ, Wray NR, Visscher PM, McRae AF, Yang J
(A1 Refereed original research article in a scientific journal)
Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study (2018)
- Journal of the American Heart Association
Matthew D. Campbell, Tomi T. Laitinen, Alun Hughes, Katja Pahkala, Markus Juonala, Mika Kähönen, Tien Y. Wong, Terho Lehtimäki, Nina Hutri-Kähönen, Olli T. Raitakari, Robyn J. Tapp
(A1 Refereed original research article in a scientific journal)