Olli Raitakari
MD/PhD
olli.raitakari@utu.fi +358 29 450 2304 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0001-9365-3702 |
cardiovascular and metabolic diseases; risk factors; vascular epidemiology; genetic epidemiology; epidemiology; dietary intervention; cohort studies; follow-up studies
EDUCATION AND DEGREES
2001 Docent in Clinical Physiology
1997-1999 Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997 Docent in Epidemiology
1996 Specialist in Clinical Physiology
1995 Doctorate, PhD
1989 Licentiate in Medicine, MD
CURRENT POSITIONS
2017- Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and
Preventive Cardiovascular Medicine, University of Turku, Finland
PAST POSITIONS
2012-2016 Academy Professor, University of Turku
2007-2016 Professor in Cardiovascular Medicine (part time), University of Turku
2007-2008 Senior Scientist Grant, Academy of Finland
2004-2016 Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
University Hospital (leave of absence 2012-2016)
2002-2004 Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital
2002 (1 mo) Head of Nuclear Medicine Department, Turku University Hospital
2000-2003 (3 mo) Head of Clinical Physiology Department, Turku University Hospital
2000-2005 Senior Fellow Post, Academy of Finland
1998-2000 Postdoctoral Research Post, Academy of Finland
1996-1997 Consultant in Clinical Physiology, Turku University Hospital
1991-1996 Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical
Physiology, Turku University Hospital
1988-1990 Positions as General Practioner and Resident in Internal Medicine or Surgery
Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018)
- Nature Genetics
(A1 Refereed original research article in a scientific journal) - Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
(A1 Refereed original research article in a scientific journal) - Genetic polymorphism of sterol transporters in children with future gallstones (2018)
- Digestive and Liver Disease
(A1 Refereed original research article in a scientific journal) - Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders (2018)
- American Journal of Human Genetics
(A1 Refereed original research article in a scientific journal) - Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes (2018)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error (2018)
- Nature Genetics
(A1 Refereed original research article in a scientific journal) - Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels (2018)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent (2018)
- Molecular Nutrition and Food Research
(A1 Refereed original research article in a scientific journal) - Geographic origin as a determinant of left ventricular mass and diastolic function – the Cardiovascular Risk in Young Finns Study (2018)
- Scandinavian Journal of Public Health
(A1 Refereed original research article in a scientific journal) - GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes (2018)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland (2018)
- American Journal of Human Genetics
(A1 Refereed original research article in a scientific journal) - Higher step count is associated with greater bone mass and strength in women but not in men (2018)
- Archives of Osteoporosis
(A1 Refereed original research article in a scientific journal) - Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood (2018)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study (2018)
- Journal of the American Heart Association
(A1 Refereed original research article in a scientific journal) - Impact of Lipid Measurements in Youth in Addition to Conventional Clinic-Based Risk Factors on Predicting Preclinical Atherosclerosis in Adulthood: The International Childhood Cardiovascular Cohort (i3C) Consortium (2018)
- Circulation
(A1 Refereed original research article in a scientific journal) - Influence of cardiovascular risk factors on longitudinal motion of the common carotid artery wall (2018)
- Atherosclerosis
(A1 Refereed original research article in a scientific journal) - Interethnic analyses of blood pressure loci in populations of East Asian and European descent (2018)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Is the Association Between Depressive Symptoms and Glucose Bidirectional? A Population-Based Study (2018)
- Health Psychology
(A1 Refereed original research article in a scientific journal) - Laseri-seurantatutkimus : liikunta-aktiivisuus lapsuudesta aikuisuuteen ja sen yhteydet muihin elintapoihin (2018)
- Liikunta ja tiede
(D1 Article in a professional journal)