Petri Susi
PhD, docent in molecular virology (University of Turku)
pesusi@utu.fi +358 29 450 4556 +358 46 922 7336 Kiinamyllynkatu 10 Turku : D7062 |
Picornavirus; enterovirus; rhinovirus; parechovirus; virus evolution; bioinformatics; respiratory pathogens; clinical virology; diagnostics; protein production technologies; bioprocesses; cell culture techniques; molecular biology; gene technology; biosecurity; research data management;
I studied biochemistry and plant biology as major subjects at University of Turku (Turku, Finland) and graduated with MSc degree in biology in 1994. The following five years (1995-1999) I worked as doctoral student at University of Helsinki (Helsinki, Finland) with prof. Eija Pehu and Dr. Kirsi Lehto, and visited Agrotechnological Research Institute (Wageningen, Netherlands; with Dr. Chris van der Schoot) and The James Hutton Institute (Dundee, UK; with Dr. Lesley Torrance) to learn new techniques. I obtained my PhD degree in the field of plant virology in 1999. As a post-doc, I first did a short visit to cancer cell biology in Turku Bioscience (in 2000; with Dr. Päivi Koskinen), before a four-year period as Academy of Finland post-doctoral researcher. During those years, I worked with FLP/FRT gene editing system in plants with a twist to plant virus movement processes in Joint Biotechnology Laboratory at University of Turku. Following that period, I switched from plant virology to human picornavirus research, and joined the group of prof. Timo Hyypiä. This started by career as a university staff member in Institute of Biomedicine (Faculty of Medicine, University of Turku). Currently, I am in a position of university lecturer in medical biotechnology and microbiology. My work history also includes research visits to diagnostic companies in Finland (2015 and 2017) and abroad (2015), two years as project manager at Turku University of Applied Sciences (2012-2013), and expert work in Tykslab clinical virology unit (2006-2012). I have co-founded two start-up companies.
I am interested in the relationship between picornavirus genome evolution, cellular infectivity and disease mechanisms, which are the key elements in therapy development. My current projects include NGS sequencing of human picornaviruses, receptor research on entero- and parechoviruses, and development of novel diagnostics to picornaviruses and novel enterovirus vectors for cancer therapy.
- The association of recombination events in the founding and emergence of subgenogroup evolutionary lineages of human enterovirus 71 (2012)
- Journal of Virology
- A combined method for rescue of modified enteroviruses by mutagenic primers, long PCR and T7 RNA polymerase-driven in vivo transcription (2011)
- Journal of Virological Methods
- Biological control of wood decay against fungal infection (2011)
- Journal of Environmental Management
- Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions (2011)
- Proceedings of the National Academy of Sciences of the United States of America
- Evolutionary Dynamics and Temporal/Geographical Correlates of Recombination in the Human Enterovirus Echovirus Types 9, 11, and 30 (2010)
- Journal of Virology
- Interaction of αVβ3 and αVβ6 integrins with human parechovirus 1 (2010)
- Journal of Virology
- Internalization of Coxsackievirus A9 Is Mediated by beta 2-Microglobulin, Dynamin, and Arf6 but Not by Caveolin-1 or Clathrin (2010)
- Journal of Virology
- Pikornavirusten käyttö geenivektoreina ja syöpäterapiassa (2010)
- Solubiologi
- Coxsackievirus A6 and hand, foot and mouth disease, Finland (2009)
- Emerging Infectious Diseases
- Integrin αVβ6 is a high-affinity receptor for coxsackievirus A9 (2009)
- Journal of General Virology
- RNA-hiljentyminen viruslääkkeenä (2009)
- Solubiologi
- Typing of enteroviruses by use of microwell oligonucleotide arrays (2009)
- Journal of Clinical Microbiology
- Clinical effects of rhinovirus infections (2008)
- Journal of Clinical Virology
- Mutagenic analysis of Potato Virus X movement protein (TGBp1) and the coat protein (CP): in vitro TGBp1–CP binding and viral RNA translation activation (2008)
- Molecular Plant Pathology
- Rhinovirus transmission within families with children: Incidence of symptomatic and asymptomatic infections (2008)
- Journal of Infectious Diseases
- Structure of the mite-transmitted Blackcurrant reversion nepovirus using electron cryo-microscopy (2008)
- Virology
- Wide-range antifungal antagonism of Paenibacillus ehimensis IB-X-b and its dependence on chitinase and β-1,3-glucanase production (2008)
- Canadian Journal of Microbiology
- RNA silencing as a general defence mechanism against pathogens (2007) Comprehensive and Molecular Phytopathology Susi P,
- Eläin- ja kasvisolujen solukuolemaprosessien yhtäläisyydet ja eroavaisuudet (2006)
- Solubiologi
- Microbial dextranases: fundamentals and biotechnological applications. (2005)
- Microbiology and Molecular Biology Reviews