Terho Heikkinen
Professor of Paediatrics, MD, PhD
Paediatric infectious diseases; respiratory infections; respiratory viruses; vaccinations; influenza; respiratory syncytial virus; otitis media
Respiratory infections in children; RESCEU (EU/IMI-funded project 2017-2021); INFORM study
Professor Terho Heikkinen graduated from the Medical School at the
University of Turku in 1984, where he also specialized in Paediatrics and Paediatric
Infectious Diseases. He defended his thesis on Development and prevention of acute
otitis media in children in 1994. Having received the European Society for
Paediatric Infectious Diseases Fellowship Award, he worked in 1996-1998 as
a post-doc Research Fellow at the University of Texas Medical Branch at
Galveston, USA. Subsequently, he worked as a Senior Clinical Researcher and
Clinical Lecturer at the Department of Paediatrics, University of Turku. Since
2016, he has been Professor of Paediatrics at
the Faculty of Medicine, University of Turku.
During the years, Terho Heikkinen has served as the chairman or a board member
of several international and domestic societies in the field of paediatric
infectious diseases, including the President of the World Society for
Pediatric Infectious Diseases. He is currently a board member of the European Scientific
Working Group on Influenza (ESWI), a scientific advisory board and executive committee member of the global Respiratory Syncytial Virus Network (ReSViNET), and the chairman of the Nordic Research Network for Paediatric Infectious Diseases (NORDPID).
Terho Heikkinen´s major research interest lies in respiratory infections,
especially those caused by influenza or respiratory syncytial viruses. In year 2000, he founded his own research group and initiated a long-term research project on respiratory virus infections in children,
including the etiology, epidemiology, diagnosis, treatment, prevention, and
overall societal impact of these infections and their complications.
Terho Heikkinen has been
actively involved in international research collaboration. In 2014, he was a founding member of ReSViNET, a global respiratory syncytial virus research network.
He is also a principal investigator in RESCEU (Respiratory syncytial virus
consortium in Europe) that in 2017 received 5-year EU/IMI funding for research
on the burden of respiratory syncytial virus infections in Europe. He was also a founding member of the Nordic Research Network for Paediatric Infectious Diseases (NORDPID) that was established in 2018.
Since 1999, Terho Heikkinen has worked as a full-time
teacher of paediatrics at the Department of Paediatrics, University of Turku. He
is also responsible for the organization of the biannual International Course
of Paediatrics & Adolescent Medicine for international Erasmus students. He
has given 188 invited lectures at various international and domestic academic
meetings.
- The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus (2024) Langedijk Annefleur C., Vrancken Bram, Lebbink Robert Jan, Wilkins Deidre, Kelly Elizabeth J., Baraldi Eugenio, Mascareñas de Los Santos Abiel Homero, Danilenko Daria M., Choi Eun Hwa, Palomino María Angélica, Chi Hsin, Keller Christian, Cohen Robert, Papenburg Jesse, Pernica Jeffrey, Greenough Anne, Richmond Peter, Martinón-Torres Federico, Heikkinen Terho, Stein Renato T., Hosoya Mitsuaki, Nunes Marta C., Verwey Charl, Evers Anouk, Kragten-Tabatabaie Leyla, Suchard Marc A., Kosakovsky Pond Sergei L., Poletto Chiara, Colizza Vittoria, Lemey Philippe, Bont Louis J., Priante Elena, Komissarova Kseniya, Yun Ki Wook, Clement Pascale, Bauck Monica, Gupta Atul, Wadia Ushma, Rivero-Calle Irene, Lumertz Magalia, Hasimoto Koichi, Madhi Shabir A.; on behalf of the INFORM-RSV Study Group
- The respiratory microbiome is linked to the severity of RSV infections and the persistence of symptoms in children (2024) Kristensen, Maartje; de Steenhuijsen, Piters Wouter A.A.; Wildenbeest, Joanne; van Houten, Marlies A.; Zuurbier, Roy P.; Hasrat, Raiza; Arp, Kayleigh; Chu, Mei Ling J.N.; Billard, Marie; Heikkinen, Terho; Cunningham, Steve; Snape, Matthew; Drysdale, Simon B.; Thwaites, Ryan S.; Martinon-Torres, Federico; Pollard, Andrew J.; Openshaw, Peter J.M.; Aerssen, Jeroen; Binkowska, Justyna; Bont, Louis; Bogaert, Debby; REspiratory Syncytial virus Consortium in EUrope (RESCEU) investigators
- Uudet keinot käyttöön RSV:n ehkäisyssä (2024) Heinonen, Santtu; Heikkinen, Terho
- Burden of Respiratory Syncytial Virus in the European Union: estimation of RSV-associated hospitalizations in children under 5 years (2023)
- Journal of Infectious Diseases
Del Riccio M, Spreeuwenberg P, Osei-Yeboah R, Johannesen CK, Fernandez LV, Teirlinck AC, Wang X, Heikkinen T, Bangert M, Caini S, Campbell H, Paget J; RESCEU investigators
- Cost-effectiveness of monoclonal antibody and maternal immunization against respiratory syncytial virus (RSV) in infants: Evaluation for six European countries (2023) Getaneh Abraham M, Li Xiao, Mao Zhuxin, Johannesen Caroline K, Barbieri Eelisa, van Summeren Jojanneke, Wang Xin, Tong Sabine, Baraldi Eugenio, Phijffer Emily, Rizzo Caterina, van Wijhe Maarten, Heikkinen Terho, Bont Louis, Willem Lander, Jit Mark, Beutels Philippe, Bilcke Joke; for Respiratory Syncytial Virus Consortium in Europe (RESCEU) investigators
- Economic burden and health-related quality-of-life among infants with respiratory syncytial virus infection: A multi-country prospective cohort study in Europe (2023) Mao Zhuxin, Li Xiao, Dacosta-Urbieta Ana, Billard Marie-Noëlle, Wildenbeest Joanne, Korsten Koos, Martinón-Torres Federico, Heikkinen Terho, Cunningham Steve, Snape Matthew D, Robinson Hannah, Pollard Andrew J, Postma Maarten, Dervaux Benoit, Hens Niels, Bont Louis, Bilcke Joke, Beutels Philippe, for RESCEU investigators
- Hengitystieinfektiot: influenssa (2023) Lastentaudit Peltola Ville, Heikkinen Terho
- Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data (2023)
- Lancet Infectious Diseases
Wilkins Deidre, Langedijk Annefleur C, Lebbink Robert Jan, Morehouse Christopher, Abram Michael E, Ahani Bahar, Aksyuk Anastasia A, Baraldi Eugenio, Brady Tyler, Tian Chen Albert, Chi Hsin, Choi Eun Hwa, Cohen Robert, Danilenko Daria M, Gopalakrishnan Vancheswaran, Greenough Anne, Heikkinen Terho, Hosoya Mitsuaki, Keller Christian, Kelly Elizabeth J, Kragten-Tabatabaie Leyla, Martinón-Torres Federico, Homero Mascareñas de Los Santos Abiel, Nunes Marta C, Palomino María Angélica, Papenburg Jesse, Pernica Jeffrey M, Richmond Peter, Stein Renato T, Tuffy Kevin M, Verwey Charl, Esser Mark T, Tabor David E, Bont Louis J; INFORM-RSV Study Group
- Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape (2023)
- Lancet Infectious Diseases
Mazur Natalie I, Terstappen Jonne, Baral Ranju, Bardají Azucena, Beutels Philippe, Buchholz Ursula J, Cohen Cheryl, Crowe James E, Cutland Clare L, Eckert Linda, Feikin Daniel, Fitzpatrick Tiffany, Fong Youyi, Graham Barney S, Heikkinen Terho, Higgins Deborah, Hirve Siddhivinayak, Klugman Keith P, Kragten-Tabatabaie Leyla, Lemey Philippe, Libster Romina, Löwensteyn Yvette, Mejias Asuncion, Munoz Flor M, Munywoki Patrick K, Mwananyanda Lawrence, Nair Harish, Nunes Marta C, Ramilo Octavio, Richmond Peter, Ruckwardt Tracy J, Sande Charles, Srikantiah Padmini, Thacker Naveen, Waldstein Kody A, Weinberger Dan, Wildenbeest Joanne, Wiseman Dexter, Zar Heather J, Zambon Maria, Bont Louis
- The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study (2023)
- The Lancet Respiratory Medicine
Wildenbeest Joanne G, Billard Marie-Noëlle, Zuurbier Roy P, Korsten Koos, Langedijk Annefleur C, van de Ven Peter M, Snape Matthew D, Drysdale Simon B, Pollard Andrew J, Robinson Hannah, Heikkinen Terho, Cunningham Steve, O'Neill Thomas, Rizkalla Bishoy, Dacosta-Urbieta Ana, Martinón-Torres Federico, van Houten Marlies A, Bont Louis J, RESCEU Investigators
- Trends and Changes in Influenza-associated Hospitalizations in Children During 25 Years in Finland, 1993–2018 (2023)
- Pediatric Infectious Disease Journal
Mattila Janna-Maija, Vuorinen Tytti, Heikkinen Terho
- Age-Specific Estimates of Respiratory Syncytial Virus-Associated Hospitalizations in 6 European Countries: A Time Series Analysis (2022)
- Journal of Infectious Diseases
Johannesen Caroline K, van Wijhe Maarten, Tong Sabine, Fernández Liliana V, Heikkinen Terho, van Boven Michiel, Wang Xin, Bøås Håkon, Li You, Campbell Harry, Paget John, Stona Luca, Teirlinck Anne, Lehtonen Toni, Nohynek Hanna, Bangert Mathieu, Fischer Thea K; for the RESCEU Investigators
- A Systematic Review of European Clinical Practice Guidelines for Respiratory Syncytial Virus Prophylaxis (2022)
- Journal of Infectious Diseases
Reeves Rachel M, van Wijhe Maarten, Lehtonen Toni, Stona Luca, Teirlinck Anne C, Fernandez Liliana Vazquez, Li You, Osei-Yeboah Richard, Fischer Thea K, Heikkinen Terho, van Boven Michiel, Bøås Håkon, Donà Daniele, Barbieri Elisa, Campbell Harry ;RESCEU Investigators
- Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis (2022) Li You, Wang Xin, Blau Dianna M, Caballero Mauricio T, Feikin Daniel R, Gill Christopher J, Madhi Shabir A, Omer Saad B, Simoes Eric AF, Campbell Harry, Pariente Ana Bermejo, Bardach Darmaa, Bassat Quique, Casalegno Jean-Sebastien, Chakhunashvili Giorgi, Crawford Nigel, Danilenko Daria, Ha Do Lien Anh, Echavarria Marcela, Gentile Angela, Gordon Aubree, Heikkinen Terho, Huang Q Sue, Jullien Sophie, Krishnan Anand, Lopez Eduardo Luis, Markic Josko, Mira-Iglesias Ainara, Moore Hannah C, Moyes Jocelyn, Mwananyanda Lawrence, Nokes D James, Noordeen Faseeha, Obodai Evangeline, Palani Nandhini, Romero Candice, Salimi Vahid, Satav Ashish, Seo Euri, Shchomak Zakhar, Singleton Rosalyn, Stolyarov Kirill, Stoszek Sonia K, von Gottberg Anne, Wurzel Danielle, Yoshida Lay-Myint, Yung Chee Fu, Zar Heather J, Nair Harish; Respiratory Virus Global Epidemiology Network; RESCEU investigators
- Lasten influenssainfektioita ei pidä unohtaa: lasten influenssasta aiheutuvan tautitaakan keventäminen on tärkeää koko yhteiskunnalle (2022) Heikkilä Terho
- Respiratory Syncytial Virus-Associated Hospital Admissions and Bed Days in Children <5 Years of Age in 7 European Countries (2022)
- Journal of Infectious Diseases
Wang Xin, Li You, Fernandez Liliana Vazquez, Teirlinck Anne C, Lehtonen Toni, van Wijhe Maarten, Stona Luca, Bangert Mathieu, Reeves Rachel M, Bøås Håkon, van Boven Michiel, Heikkinen Terho, Johannesen Caroline Klint, Baraldi Eugenio, Dona Donà, Tong Sabine, Campbell Harry; Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators
- Burden of influenza during the first year of life (2021)
- Influenza and Other Respiratory Viruses
Mattila Janna‐Maija, Thomas Emilia, Lehtinen Pasi, Vuorinen Tytti, Waris Matti, Heikkinen Terho
- Burden of Respiratory Syncytial Virus Infection During the First Year of Life (2021)
- Journal of Infectious Diseases
Thomas Emilia, Mattila Janna-Maija, Lehtinen Pasi, Vuorinen Tytti, Waris Matti, Heikkinen Terho
- Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus (2021) Lin Gu-Lung, Drysdale Simon B., Snape Matthew D., O’Connor Daniel, Brown Anthony, MacIntyre-Cockett George, Mellado-Gomez Esther, de Cesare Mariateresa, Bonsall David, Ansari M. Azim, Öner Deniz, Aerssens Jeroen, Butler Christopher, Bont Louis, Openshaw Peter, Martinón-Torres Federico, Nair Harish, Bowden Rory; RESCEU Investigators, Golubchik Tanya, Pollard Andrew J.
- Global Molecular Epidemiology of Respiratory Syncytial Virus from the 2017-2018 INFORM-RSV Study (2021)
- Journal of Clinical Microbiology
Tabor David E, Fernandes Fiona, Langedijk Annefleur C, Wilkins Deidre, Lebbink Robert Jan, Tovchigrechko Andrey, Ruzin Alexey, Kragten-Tabatabaie Leyla, Jin Hong, Esser Mark T, Bont Louis J, Abram Michael E; the INFORM-RSV Study Group