PhD Eeva-Christine Brockmann - UTU Research Portal

Eeva-Christine Brockmann
PhD

- Senior Researcher,
Biotechnology (Department of Life Technologies)

eechbr@utu.fi

+358 29 450 4590

+358 50 345 9103

Kiinamyllynkatu 10

Turku

Office: D6020

ORCID identifier: https://orcid.org/0009-0005-0362-0402(external)

Areas of expertise

Phage display; antibodies; antibody engineering; recombinant antibody libraries; immunoassays; diagnostics; molecular biology; protein expression and purification; antibody affinity and stability

Publications

Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cellsChimeric recombinant antibody fragments in cardiac troponin I immunoassay (2024)
- Biomedicine and PharmacotherapyClinical Biochemistry
Saha, Nayanendu; Lee, Sang Gyu; Brockmann, Eeva-Christine; de la Cruz, M. Jason; Goldgur, Yehuda; Mendoza, Rachelle P.; Stanchina, Elisa de; Love, Tanzy M.; Marvald, Josh; Xu, Yan; Xu, Kai; Himanen, Juha P.; Lamminmäki, Urpo; Veach, Darren; Nikolov, Dimitar B.
(A1 Refereed original research article in a scientific journal)
Plasma CHI3L1 associates with increased TSPO-PET measurable microglial activation in patients with progressive multiple sclerosis (2024)
- Multiple Sclerosis
40th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 18-20 September 2024, Copenhagen, Denmark Ahola, Venla; Saraste, Maija; Matilainen, Markus; Brockmann, Eeva-Christine; Lamminmaki, Urpo; Airas, Laura
(Poster)
Isolation and functional analysis of phage-displayed antibody fragments targeting the staphylococcal superantigen-like proteinsLactobacillus helveticus MIMLh5-specific antibodies for detection of S-layer protein in Grana Padano protected-designation-of-origin cheese (2023)
- MicrobiologyOpenApplied and Environmental Microbiology
Alanko Ida, Sandberg Rebecca, Brockmann Eeva-Christine, de Haas Carla J. C., van Strijp Jos A. G., Lamminmäki Urpo, Salo-Ahen Outi M. H.
(A1 Refereed original research article in a scientific journal)
Isolation and characterization of phage display-derived scFv antibodies against human parechovirus 1 VP0 protein (2022)
- Scientific Reports
Hietanen Eero, Tripathi Lav, Brockmann Eeva-Christine, Merilahti Pirjo, Lamminmäki Urpo, Susi Petri
(A1 Refereed original research article in a scientific journal)
Combinatorial mutagenesis with alternative CDR-L1 and-H2 loop lengths contributes to affinity maturation of antibodies (2021)
- New Biotechnology
Brockmann Eeva-Christine, Pyykkö Mikko, Hannula Heidi, Khan Kamran, Lamminmäki Urpo, Huovinen Tuomas
(A1 Refereed original research article in a scientific journal)
Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation (2020)
- Calcified Tissue International
Arponen Milja, Brockmann Eeva-Christine, Kiviranta Riku, Lamminmäki Urpo, Ivaska Kaisa K
(A1 Refereed original research article in a scientific journal)
Identification and analysis of anti-HDL scFv-antibodies obtained from phage display based synthetic antibody library – Phage display derived HDL antibodies (2016)
- Clinical Biochemistry
Priyanka Negi,Janita Lövgren,Päivi Malmi,Nina Sirkka,Jari Metso,Tuomas Huovinen,Eeva-Christine Brockmann,Kim Pettersson,Matti Jauhiainen,Urpo Lamminmäki
(A1 Refereed original research article in a scientific journal)
(2015)
Heidi Hyytiä, Taina Heikkilä, Eeva-Christine Brockmann, Henna Kekki, Pirjo Hedberg, Tarja Puolakanaho, Timo Lövgren, Kim Pettersson
(A1 Refereed original research article in a scientific journal)
Phage display aided improvement of a unique prostate-specific antigen (PSA) antibody unreactive with Lys(145)-Lys(146) internally cleaved formsUse of high-capacity surface with oriented recombinant antibody fragments in a 5-min immunoassay for thyroid-stimulating hormone (2015)
- Journal of Immunological MethodsAnalytical Biochemistry
Ferdhos Khan Liton, Mari T. Peltola, Markus Vehniäinen, Erica Kuusela, Tiina Pettersson, Urpo Lamminmäki, Kim Pettersson, Eeva-Christine Brockmann
(A1 Refereed original research article in a scientific journal)
(2014)
Milda Stuknytė, Eeva-Christine Brockmann, Tuomas Huovinen, Simone Guglielmetti, Diego Mora, Valentina Taverniti, Stefania Arioli, Ivano De Noni, Urpo Lamminmäki
(A1 Refereed original research article in a scientific journal)
Two ScFv antibody libraries derived from identical VLVH framework with different binding site designs display distinct binding profiles (2013)
- Protein Engineering, Design and Selection
Huovinen T, Syrjanpää M, Sanmark H, Brockmann EC, Azhayev A, Wang Q, Vehniäinen M, Lamminmäki U
(A1 Refereed original research article in a scientific journal)
Primer Extension Mutagenesis Powered by Selective Rolling Circle Amplification (2012)
- PLoS ONE
Huovinen T, Brockmann EC, Akter S, Perez-Gamarra S, Yla-Pelto J, Liu Y, Lamminmaki U
(A1 Refereed original research article in a scientific journal)
Selection of Stable scFv Antibodies by Phage Display (2012) Antibody Engineering: Methods and Protocols, Second Edition Eeva-Christine Brockmann
(B2 Non-refereed book chapter or chapter in a compilation book)
Synthetic single-framework antibody library integrated with rapid affinity maturation by V-L shuffling (2011)
- Protein Engineering, Design and Selection
Brockmann EC, Akter S, Savukoski T, Huovinen T, Lehmusvuori A, Leivo J, Saavalainen O, Azhayev A, Lovgren T, Hellman J, Lamminmaki U
(A1 Refereed original research article in a scientific journal)
(2010)
Brockmann EC, Vehniäinen M, Pettersson K
(A1 Refereed original research article in a scientific journal)