Jukka Westermarck
MD, PhD
jukka.westermarck@utu.fi +358 29 450 2880 +358 40 742 3007 Tykistökatu 6 Turku Office: 4124 (B-stairs, 4th floor) ORCID identifier: https://orcid.org/0000-0001-7478-3018 |
Role and regulation of phosphatases, particularly tumor suppressor protein phosphatase 2A (PP2A) in human cancers
Jukka Westermarck is a Professor of Cancer Biology, and Research Director, in the Turku Bioscience Centre at University of Turku.
Westermarck earned his medical degree from University of Turku in 1996. Two years later he obtained his PhD degree in Department of Medical Biochemistry and Department of Dermatology at the same University. He was working as a postdoctoral fellow in the laboratory of Dirk Bohmann during 1999-2001 in the European Molecular Biology Laboratory in Heidelberg, Germany. After being appointed as Academy Fellow by the Academy of Finland, he established his own research group at Turku Centre for Biotechnology in 2002. In 2006-2009 he was appointed as a group leader in the Institute of Medical Technology at University of Tampere, and after that he returned back to Turku due to his appointment as a tenure Research Director of Turku Centre for Biotechnology, and as a Professor of Cancer Biology at the Faculty of Medicine. In 2012, he worked as a visiting Professor at Dana-Farber Cancer Institute, Boston.
Professor Westermarck received young researcher prize from Finnish Medical Association Duodecim 2007, and Anders Jahre young investigator prize 2009 from University of Oslo, Norway. In 2017, he became an elected member of the Finnish Academy of Science and Letters.
Prof. Westermarck´s research focuses on role and regulation of phosphatases, particularly tumor suppressor protein phosphatase 2A (PP2A) in human cancers. Based on this work his group has identified several novel signaling principles how PP2A regulates cancer progression, as well as potential novel cancer therapy targets and diagnostic biomarkers.
- Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype (2022)
- Molecular Cancer Therapeutics
(A1 Refereed original research article in a scientific journal) - SHARPIN S146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis (2022)
- Journal of Cell Science
(A1 Refereed original research article in a scientific journal) - Cancer cell line microarray as a novel screening method for identification of radioresistance biomarkers in head and neck squamous cell carcinoma (2021)
- BMC Cancer
(A1 Refereed original research article in a scientific journal) - Cancer stem cell phosphatases (2021)
- Biochemical Journal
(A2 Refereed review article in a scientific journal ) - CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis (2021)
- Cancer Research
(A1 Refereed original research article in a scientific journal) - Circumventing drug treatment? Intrinsic lethal effects of polyethyleneimine (PEI)-functionalized nanoparticles on glioblastoma cells cultured in stem cell conditions (2021)
- Cancers
(A1 Refereed original research article in a scientific journal) - Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias (2021)
- Clinical Cancer Research
(A1 Refereed original research article in a scientific journal) - Druggable cancer phosphatases (2021)
- Science Translational Medicine
(A2 Refereed review article in a scientific journal ) - Evaluation of prognostic biomarkers in a population-validated Finnish HNSCC patient cohort (2021)
- European Archives of Oto-Rhino-Laryngology
(A1 Refereed original research article in a scientific journal) - Fosfataasien avulla syövän kimppuun (2021)
- Duodecim
(A2 Refereed review article in a scientific journal ) - The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer (2021)
- Cell
(A1 Refereed original research article in a scientific journal) - (2S, 4R)-4-[18F]Fluoroglutamine for In vivo PET Imaging of Glioma Xenografts in Mice: an Evaluation of Multiple Pharmacokinetic Models (2020)
- Molecular Imaging and Biology
(A1 Refereed original research article in a scientific journal) - CIP2A Constrains Th17 Differentiation by Modulating STAT3 Signaling (2020)
- iScience
(A1 Refereed original research article in a scientific journal) - Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models (2020)
- Neurotherapeutics
(A1 Refereed original research article in a scientific journal) - Good guy in bad company: How STRNs convert PP2A into an oncoprotein (2020)
- Cancer Cell
(B1 Non-refereed article in a scientific journal) - Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors (2020)
- Oncogene
(A1 Refereed original research article in a scientific journal) - Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma (2020)
- Brain Communications
(A1 Refereed original research article in a scientific journal) - Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 (2020)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy (2020)
- Cell
(B1 Non-refereed article in a scientific journal) - Protein interactome of the Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Th17 cells (2020)
- Current Research in Immunology
(A1 Refereed original research article in a scientific journal)