PhD Matti Poutanen - UTU Research Portal

Matti Poutanen
PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

matpou@utu.fi

+358 29 450 2632

+358 50 366 0140

Kiinamyllynkatu 10

Turku

Office: C507

ORCID identifier: https://orcid.org/000-0002-8953-1734

http://www.tcdm.fi/research/poutanen-matti/

Areas of expertise

gentically modified mice, sex steroids, endometriosis, hormonal cancer

Biography

EDUCATIONAL
TRAINING

1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland

1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland

1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland

CURRENT
POSITIONS

Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland

Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden

MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry

SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.

SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK

Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)

Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.

Research

Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.

Teaching

Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging

Publications

7 of 10

Autocrine Action of IGF2 Regulates Adult beta-Cell Mass and Function (2015)
- Diabetes
Modi H, Jacovetti C, Tarussio D, Metref S, Madsen OD, Zhang FP, Rantakari P, Poutanen M, Nef S, Gorman T, Regazzi R, Thorens B
(A1 Refereed original research article in a scientific journal)
Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes (2015)
- PLoS ONE
Sareila O, Hagert C, Rantakari P, Poutanen M, Holmdahl R
(A1 Refereed original research article in a scientific journal)
Does in utero exposure to human chorionic gonadotropin (hcg) have a protective effect on hormonal imbalances in transgenic mice? (2015)
- Placenta
Ratner LD, Stevens G, Marcia C, Farre P, Poutanen M, Calandra R, Huhtaniemi I, Rulli SB
(Other publication)
HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo (2015)
- Chemico-Biological Interactions
Jarvensivu P, Saloniemi-Heinonen T, Awosanya M, Koskimies P, Saarinen N, Poutanen M
(A1 Refereed original research article in a scientific journal)
Hydroxysteroid (17b)-dehydrogenase 1–deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production (2015)
- FASEB Journal
Janne Hakkarainen, Heli Jokela, Pirjo Pakarinen, Hanna Heikela, Laura Kätkänaho, Liesbeth Vandenput, Claes Ohlsson, Fu-Ping Zhang, and Matti Poutanen
(A1 Refereed original research article in a scientific journal)
Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane (2015)
- FASEB Journal
Björkgren I, Gylling H, Turunen H, Huhtaniemi I, Strauss L, Poutanen M, Sipilä P
(A1 Refereed original research article in a scientific journal)
Measurement of a Comprehensive Sex Steroid Profile in Rodent Serum by High-Sensitive Gas Chromatography-Tandem Mass Spectrometry (2015)
- Endocrinology
Nilsson ME, Vandenput L, Tivesten A, Norlen AK, Lagerquist MK, Windahl SH, Borjesson AE, Farman HH, Poutanen M, Benrick A, Maliqueo M, Stener-Victorin E, Ryberg H, Ohlsson C
(A1 Refereed original research article in a scientific journal)
Optimization of Statistical Methods Impact on Quantitative Proteomics Data (2015)
- Journal of Proteome Research
Pursiheimo A, Vehmas AP, Afzal S, Suomi T, Chand T, Strauss L, Poutanen M, Rokka A, Corthals GL, Elo LL,
(A1 Refereed original research article in a scientific journal)
The bone-sparing effects of estrogen and WNT16 are independent of each other (2015)
- Proceedings of the National Academy of Sciences of the United States of America
Moverare-Skrtic S, Wu JY, Henning P, Gustafsson KL, Sjogren K, Windahl SH, Koskela A, Tuukkanen J, Borjesson AE, Lagerquist MK, Lerner UH, Zhang FP, Gustafsson JA, Poutanen M, Ohlsson C
(A1 Refereed original research article in a scientific journal)
Thyrocyte-Specific Dicer1 Deficiency Alters Thyroid Follicular Organization and Prevents Goiter Development (2015)
- Endocrinology
Undeutsch H, Lof C, Pakarinen P, Poutanen M, Kero J
(A1 Refereed original research article in a scientific journal)
Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity (2015)
- Molecular and Cellular Endocrinology
Polari L., Yatkin E., Martínez Chacón M., Ahotupa M., Smeds A., Strauss L., Zhang F., Poutanen M., Saarinen N., Mäkelä S.
(A1 Refereed original research article in a scientific journal)
Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model (2014)
- American Journal of Pathology
Matias Knuuttila, Emrah Yatkin, Jenny Kallio, Saija Savolainen, Teemu D. Laajala, Tero Aittokallio, Riikka Oksala, Merja Häkkinen, Pekka Keski-Rahkonen, Seppo Auriola, Matti Poutanen, Sari Mäkelä
(A1 Refereed original research article in a scientific journal)
Castration induces upregulation of intratumoral androgen biosynthesis and androgen receptor expression in orthotopic VCaP human prostate cancer xenograft model (2014)
- Cancer Research
Matias Knuuttila, Emrah Yatkin, Jenny Kallio, Saija Savolainen, Teemu Daniel Laajala, Tero Aittokallio, Riikka Oksala, Merja Häkkinen, Pekka Keski-Rahkonen, Seppo Auriola, Matti Poutanen, Sari Mäkelä
(Other publication)
Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: effect of androgens (2014)
- Molecular and Cellular Endocrinology
Betina Gonzalez, Laura D. Ratner, María J. Scerbo, Noelia P. Di Giorgio, Matti Poutanen, Ilpo T. Huhtaniemi, Ricardo S. Calandra, Victoria A.R. Lux-Lantos, María J. Cambiasso, Susana B. Rulli
(A1 Refereed original research article in a scientific journal)
ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. (2014)
- Molecular Endocrinology -Baltimore-
Florence Naillat, Ville Veikkolainen, Ilkka Miinalainen, Petra Sipilä, Matti Poutanen, Klaus Elenius, Seppo J. Vainio
(A1 Refereed original research article in a scientific journal)
Human Testicular Peritubular Cells Host Putative Stem Leydig Cells With Steroidogenic Capacity (2014)
- Journal of Clinical Endocrinology and Metabolism
Landreh L, Spinnler K, Schubert K, Hakkinen MR, Auriola S, Poutanen M, Soder O, Svechnikov K, Mayerhofer A
(A1 Refereed original research article in a scientific journal)
Intra-Tissue Steroid Profiling Indicates Differential Progesterone and Testosterone Metabolism in the Endometrium and Endometriosis Lesions (2014)
- Journal of Clinical Endocrinology and Metabolism
Huhtinen K, Saloniemi-Heinonen T, Keski-Rahkonen P, Desai R, Laajala D, Ståhle M, Häkkinen M, Laajala D, Suvitie P, Awosanya M, Aittokallio T, Handelsman D, Auriola S, Perheentupa A, Poutanen M.
(A1 Refereed original research article in a scientific journal)
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. (2014)
- Nature Medicine
Sofia Movérare-Skrtic, Petra Henning, Xianwen Liu, Kenichi Nagano, Hiroaki Saito, Anna E Börjesson, Klara Sjögren, Sara H Windahl, Helen Farman, Bert Kindlund, Cecilia Engdahl, Antti Koskela, Fu-Ping Zhang, Emma E Eriksson, Farasat Zaman, Ann Hammarstedt, Hanna Isaksson, Marta Bally, Ali Kassem, Catharina Lindholm, Olof Sandberg, Per Aspenberg, Lars Sävendahl, Jian Q Feng, Jan Tuckermann, Juha Tuukkanen, Matti Poutanen, Roland Baron, Ulf H Lerner, Francesca Gori, Claes Ohlsson
(A1 Refereed original research article in a scientific journal)
Ovarian Endometriosis Signatures Established through Discovery and Directed Mass Spectrometry Analysis (2014)
- Journal of Proteome Research
Vehmas AP, Muth-Pawlak D, Huhtinen K, Saloniemi-Heinonen T, Jaakkola K, Laajala TD, Kaprio H, Suvitie PA, Aittokallio T, Siitari H, Perheentupa A, Poutanen M, Corthals GL
(A1 Refereed original research article in a scientific journal)
A reporter mouse model reveals that human CYP19A1 (aromatase) gene expression is induced in breast cancer xenograft stroma and surrounding mammary gland by the cancer cells in vivo. (2013)
- Cancer Research
Järvensivu P, Strauss L, Mäkelä S, Poutanen M, Saarinen N
(Other publication)

CURRENTPOSITIONS

CURRENT
POSITIONS