Matti Poutanen
PhD
matpou@utu.fi +358 29 450 2632 +358 50 366 0140 Kiinamyllynkatu 10 Turku Työhuone: C507 ORCID-tunniste: https://orcid.org/000-0002-8953-1734 |
geenimuunnellut eläimet, steroidi hormoni, endometrioosi, hormonaalinen syöpä
EDUCATIONAL
TRAINING
1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland
1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland
1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland
CURRENT
POSITIONS
Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland
Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden
MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry
SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.
SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK
Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)
Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.
Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging
- Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo (2012)
- Clinical Cancer Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterne myocytes (2012)
- Journal of Cellular and Molecular Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Loss of Bmyc results in increased apoptosis associated with upregulation Myc expression in juvenile murine testis (2012)
- Reproduction
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Serum HE4 concentration is not dependent on menstrual cycle or hormonal treatment among endometriosis patients and healthy premenopausal women (2012)
- Gynecologic Oncology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Short-Term Pharmacological Suppression of the Hyperprolactinemia of Infertile hCG-Overproducing Female Mice Persistently Restores Their Fertility (2012)
- Endocrinology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The diversity of sex steroid action: novel functions of hydroxysteroid (17 beta) dehydrogenases as revealed by genetically modified mouse models (2012)
- Journal of Endocrinology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Understanding the diversity of sex steroid action (2012)
- Journal of Endocrinology
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - A Single Dose of Enterolactone Activates Estrogen Signaling and Regulates Expression of Circadian Clock Genes in Mice (2011)
- Journal of Nutrition
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Down-Regulation of the Histone Methyltransferase EZH2 Contributes to the Epigenetic Programming of Decidualizing Human Endometrial Stromal Cells (2011)
- Molecular Endocrinology -Baltimore-
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Endogenously elevated androgens alter the developmental programming of the hypothalamic-pituitary axis in male mice (2011)
- Molecular and Cellular Endocrinology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )



