Matti Poutanen
PhD
matpou@utu.fi +358 29 450 2632 +358 50 366 0140 Kiinamyllynkatu 10 Turku : C507 : https://orcid.org/000-0002-8953-1734 |
gentically modified mice, sex steroids, endometriosis, hormonal cancer
EDUCATIONAL
TRAINING
1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland
1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland
1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland
CURRENT
POSITIONS
Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland
Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden
MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry
SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.
SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK
Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)
Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.
Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging
7 of 10
- Autocrine Action of IGF2 Regulates Adult beta-Cell Mass and Function (2015)
- Diabetes
- Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes (2015)
- PLoS ONE
- Does in utero exposure to human chorionic gonadotropin (hcg) have a protective effect on hormonal imbalances in transgenic mice? (2015)
- Placenta
- HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo (2015)
- Chemico-Biological Interactions
- Hydroxysteroid (17b)-dehydrogenase 1–deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production (2015)
- FASEB Journal
- Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane (2015)
- FASEB Journal
- Measurement of a Comprehensive Sex Steroid Profile in Rodent Serum by High-Sensitive Gas Chromatography-Tandem Mass Spectrometry (2015)
- Endocrinology
- Optimization of Statistical Methods Impact on Quantitative Proteomics Data (2015)
- Journal of Proteome Research
- The bone-sparing effects of estrogen and WNT16 are independent of each other (2015)
- Proceedings of the National Academy of Sciences of the United States of America
- Thyrocyte-Specific Dicer1 Deficiency Alters Thyroid Follicular Organization and Prevents Goiter Development (2015)
- Endocrinology
- Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity (2015)
- Molecular and Cellular Endocrinology
- Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model (2014)
- American Journal of Pathology
- Castration induces upregulation of intratumoral androgen biosynthesis and androgen receptor expression in orthotopic VCaP human prostate cancer xenograft model (2014)
- Cancer Research
- Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: effect of androgens (2014)
- Molecular and Cellular Endocrinology
- ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. (2014)
- Molecular Endocrinology -Baltimore-
- Human Testicular Peritubular Cells Host Putative Stem Leydig Cells With Steroidogenic Capacity (2014)
- Journal of Clinical Endocrinology and Metabolism
- Intra-Tissue Steroid Profiling Indicates Differential Progesterone and Testosterone Metabolism in the Endometrium and Endometriosis Lesions (2014)
- Journal of Clinical Endocrinology and Metabolism
- Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. (2014)
- Nature Medicine
- Ovarian Endometriosis Signatures Established through Discovery and Directed Mass Spectrometry Analysis (2014)
- Journal of Proteome Research
- A reporter mouse model reveals that human CYP19A1 (aromatase) gene expression is induced in breast cancer xenograft stroma and surrounding mammary gland by the cancer cells in vivo. (2013)
- Cancer Research
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