Matti Poutanen
PhD
matpou@utu.fi +358 29 450 2632 +358 50 366 0140 Kiinamyllynkatu 10 Turku : C507 : https://orcid.org/000-0002-8953-1734 |
gentically modified mice, sex steroids, endometriosis, hormonal cancer
EDUCATIONAL
TRAINING
1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland
1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland
1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland
CURRENT
POSITIONS
Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland
Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden
MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry
SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.
SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK
Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)
Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.
Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging
6 of 10
- WNT16 overexpression partly protects against glucocorticoid-induced bone loss (2018)
- American Journal of Physiology : Endocrinology and Metabolism
- Defects in chondrocyte maturation and secondary ossification in mouse knee joint epiphyses due to Snorc deficiency (2017)
- Osteoarthritis and Cartilage
- Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease (2017)
- Scientific Reports
- Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty (2017)
- Scientific Reports
- Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice (2017)
- American Journal of Physiology : Endocrinology and Metabolism
- In Vivo Expression of miR-32 Induces Proliferation in Prostate Epithelium (2017)
- American Journal of Pathology
- Matched preclinical designs for improved translatability (2017)
- Science Translational Medicine
- Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development (2017)
- Development
- A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources (2016)
- Clinical Chemistry
- Diffusion weighted imaging of prostate cancer xenografts: comparison of bayesian modeling and independent least squares fitting (2016)
- International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition. Proceedings
- Fam3c modulates osteogenic cell differentiation and affects bone volume and cortical bone mineral density (2016)
- BoneKEy Reports
- From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo (2016)
- Toxicology Letters
- Generation of membrane-bound catechol-O-methyl transferase deficient mice with distinct sex dependent behavioral phenotype (2016)
- Journal of Physiology and Pharmacology
- Hyperprolactinemia induced by hCG leads to metabolic disturbances in female mice (2016)
- Journal of Endocrinology
- Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse (2016)
- Journal of Proteomics
- Optimized design and analysis of preclinical intervention studies in vivo (2016)
- Scientific Reports
- Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells (2016)
- Scientific Reports
- Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption (2016)
- Gut
- Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding (2016)
- Molecular and Cellular Endocrinology
- The Hydroxysteroid (17 beta) Dehydrogenase Family Gene HSD17B12 Is Involved in the Prostaglandin Synthesis Pathway, the Ovarian Function, and Regulation of Fertility (2016)
- Endocrinology
UTU Research Portal