Matti Poutanen
PhD
matpou@utu.fi +358 29 450 2632 +358 50 366 0140 Kiinamyllynkatu 10 Turku : C507 : https://orcid.org/000-0002-8953-1734 |
gentically modified mice, sex steroids, endometriosis, hormonal cancer
EDUCATIONAL
TRAINING
1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland
1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland
1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland
CURRENT
POSITIONS
Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland
Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden
MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry
SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.
SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK
Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)
Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.
Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging
5 of 10
- The gut microbiota is a major regulator of androgen metabolism in intestinal contents (2019)
- American Journal of Physiology : Endocrinology and Metabolism
- A cancer-specific detection of serum CA125 improves differential diagnosis of epithelial ovarian cancer from benign conditions. (2018)
- Clinical Cancer Research
- Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts (2018)
- American Journal of Pathology
- Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue (2018)
- Journal of Pharmaceutical and Biomedical Analysis
- Animal Models for Human Endocrine Disorders: Preface (2018)
- Best Practice and Research: Clinical Endocrinology and Metabolism
- Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts (2018)
- American Journal of Pathology
- CA125 glycoform assay improves the performance of conventional CA125 in the diagnostics of epithelial ovarian cancer (2018)
- International Journal of Gynecological Cancer
- Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria (2018)
- Nucleic Acids Research
- HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium (2018)
- Endocrine-Related Cancer
- Hydroxysteroid (17 beta) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice (2018)
- FASEB Journal
- Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility (2018)
- FASEB Journal
- Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice (2018)
- Thyroid
- Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice (2018)
- Journal of Endocrinology
- Insights into the role of androgen receptor in human testicular peritubular cells (2018)
- Andrology
- Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer (2018)
- Endocrine-Related Cancer
- Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling (2018)
- Proceedings of the National Academy of Sciences of the United States of America
- NLRP3 in somatic non-immune cells of rodent and primate testes (2018)
- Reproduction
- Partial thyrocyte-specific Gαs deficiency leads to rapid-onset hypothyroidism, hyperplasia, and papillary thyroid carcinoma-like lesions in mice (2018)
- FASEB Journal
- Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis (2018)
- Human Reproduction
- The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer (2018)
- Oncology
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