Matti Poutanen
PhD
matpou@utu.fi +358 29 450 2632 +358 50 366 0140 Kiinamyllynkatu 10 Turku : C507 : https://orcid.org/000-0002-8953-1734(external) |
gentically modified mice, sex steroids, endometriosis, hormonal cancer
EDUCATIONAL
TRAINING
1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland
1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland
1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland
CURRENT
POSITIONS
Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland
Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden
MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry
SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.
SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK
Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)
Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.
Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging
4 of 10
- Interplay between gonadal hormones and postnatal overfeeding in defining sex-dependent differences in gut microbiota architecture (2020)
- Aging
- Neonatal exposure to androgens dynamically alters gut microbiota architecture (2020)
- Journal of Endocrinology
- Phenotypic characterization of transgenic mouse models overproducing hCG (2020) 100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives Rulli Susana B, Poutanen Matti, Huhtaniemi Ilpo T
- Phosphorylation site S122 in estrogen receptor alpha has a tissue-dependent role in female mice (2020)
- FASEB Journal
- Role of kisspeptins in the control of the hypothalamic-pituitary-ovarian axis: old dogmas and new challenges (2020)
- Fertility and Sterility
- The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency (2020)
- FASEB Journal
- Transcriptomic responses to hypoxia in endometrial and decidual stromal cells (2020)
- Reproduction
- Uusia työkaluja paikallisesti edenneen ja etäpesäkkeisen eturauhassyövän lääkehoitoon (2020)
- Duodecim
- Androgen receptor SUMOylation regulates bone mass in male mice (2019)
- Molecular and Cellular Endocrinology
- Applying mass spectrometric methods to study androgen biosynthesis and metabolism in prostate cancer (2019)
- Journal of Molecular Endocrinology
- Biology and clinical relevance of Hydroxysteroid (17beta)dehydrogenase enzymes (2019)
- Molecular and Cellular Endocrinology
- Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs (2019)
- Reproductive Sciences
- Europium Nanoparticle-Based Sialyl-Tn Monoclonal Antibody Discriminates Epithelial Ovarian Cancer-Associated CA125 from Benign Sources (2019)
- The Journal of Applied Laboratory Medicine
- Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus (2019)
- Neuroendocrinology
- Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis (2019)
- Metabolism
- Interleukin-6 in the central amygdala is bioactive and co-localised with glucagon-like peptide-1 receptor (2019)
- Journal of Neuroendocrinology
- Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction (2019)
- Nature Communications
- Personalized Drug Sensitivity Screening for Bladder Cancer Using Conditionally Reprogrammed Patient-derived Cells (2019)
- European Urology
- Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseases (2019)
- Molecular and Cellular Endocrinology
- Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue (2019)
- Journal of Pharmaceutical and Biomedical Analysis
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