PhD Matti Poutanen - UTU Research Portal

Matti Poutanen
PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

matpou@utu.fi

+358 29 450 2632

+358 50 366 0140

Kiinamyllynkatu 10

Turku

: C507

: https://orcid.org/000-0002-8953-1734

http://www.tcdm.fi/research/poutanen-matti/

gentically modified mice, sex steroids, endometriosis, hormonal cancer

EDUCATIONAL
TRAINING

1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland

1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland

1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland

CURRENT
POSITIONS

Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland

Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden

MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry

SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.

SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK

Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)

Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.

Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.

Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging

3 of 10

Steroidogenic factor 1 (NR5A1) induces multiple transcriptional changes during differentiation of human gonadal-like cells (2022)
- Differentiation
Sepponen Kirsi, Lundin Karolina, Yohannes Dawit A, Vuoristo Sanna, Balboa Diego, Poutanen Matti, Ohlsson Claes, Hustad Steinar, Bifulco Ersilia, Paloviita Pauliina, Otonkoski Timo, Ritvos Olli, Sainio Kirsi, Tapanainen Juha S, Tuuri Timo
The variant rs77559646 associated with aggressive prostate cancer disrupts ANO7 mRNA splicing and protein expression (2022)
- Human Molecular Genetics
Wahlström Gudrun, Heron Samuel, Knuuttila Matias, Kaikkonen Elina, Tulonen Nea, Metsälä Olli, Lof Christoffer, Ettala Otto, Boström Peter J., Taimen Pekka, Poutanen Matti, Schleutker Johanna
AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction (2021)
- Metabolism
Franssen D, Barroso A, Ruiz-Pino F, Vázquez MJ, Garcia-Galiano D, Castellano JM, Onieva R, Ruiz-Cruz M, Poutanen M, Gaytán F, Diéguez C, Pinilla L, Lopez M, Roa J, Tena-Sempere M
Comparative Analysis of the Effects of Long-Term 3,5-diiodothyronine Treatment on the Murine Hepatic Proteome and Transcriptome Under Conditions of Normal Diet and High-Fat Diet (2021)
- Thyroid
Lietzow Julika, Golchert Janine, Pietzner Maik, Volker Uwe, Poutanen Matti, Ohlsson Claes, Homuth Georg, Kohrle Josef
Correction: MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility (vol 4, pg 3, 2021) (2021)
- Life Science Alliance
Lahiri Shibojyoti, Aftab Wasim, Walenta Lena, Strauss Leena, Poutanen Matti, Mayerhofer Artur, Imhof Axel
Docetaxel chemotherapy response in PC3 prostate cancer mouse model detected by rotating frame relaxations and water diffusion (2021)
- NMR in Biomedicine
Laakso Hanne, Ylä-Herttuala Elias, Sierra Alejandra, Jambor Ivan, Poutanen Matti, Liljenbäck Heidi, Virtanen Helena, Merisaari Harri, Aronen Hannu, Minn Heikki, Roivainen Anne, Liimatainen Timo
Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis (2021)
- International Journal of Molecular Sciences
Eubler Katja, Rantakari Pia, Gerke Heidi, Herrmann Carola, Missel Annika, Schmid Nina, Walenta Lena, Lahiri Shibojyoti, Imhof Axel, Strauss Leena, Poutanen Matti, Mayerhofer Artur
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility (2021)
- Life Science Alliance
Lahiri Shibojyoti, Aftab Wasim, Walenta Lena, Strauss Leena, Poutanen Matti, Mayerhofer Artur, Imhof Axel
Pulsed administration for physiological estrogen replacement in mice (2021)
- F1000Research
Corciulo Carmen, Scheffler Julia M., Gustafsson Karin L., Drevinge Christina, Humeniuk Piotr, del Carpio Pons Alicia M., Poutanen Matti, Ohlsson Claes, Lagerquist Marie K, Islander Ulrika
Statistical Evaluation of Different Mathematical Models for Diffusion Weighted Imaging of Prostate Cancer Xenografts in Mice (2021)
- Frontiers in Oncology
Merisaari Harri, Laakso Hanne, Liljenbäck Heidi, Virtanen Helena, Aronen Hannu J., Minn Heikki, Poutanen Matti, Roivainen Anne, Liimatainen Timo, Jambor Ivan
Testicular adenosine acts as a pro-inflammatory molecule: role of testicular peritubular cells (2021)
- Molecular Human Reproduction
Missel Annika, Walenta Lena, Eubler Katja, Mundt Nadine, Heikelä Hanna, Pickl Ulrich, Trottmann Matthias, Popper Bastian, Poutanen Matti, Strauss Leena, Köhn Frank-Michael, Kunz Lars, Spehr Marc, Mayerhofer Artur
The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation (2021)
- EMBO Reports
El Kharraz Sarah, Dubois Vanessa, van Royen Martin E, Houtsmuller Adriaan B, Pavlova Ekaterina, Atanassova Nina, Nguyen Tien, Voet Arnout, Eerlings Roy, Handle Florian, Prekovic Stefan, Smeets Elien, Moris Lisa, Devlies Wout, Ohlsson Claes, Poutanen Matti, Verstrepen Kevin J, Carmeliet Geert, Launonen Kaisa-Mari, Helminen Laura, Palvimo Jorma J, Libert Claude, Vanderschueren Dirk, Helsen Christine, Claessens Frank
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer (2020)
- Nature Communications
Tiwari R, Manzar N, Bhatia V, Yadav A, Nengroo MA, Datta D, Carskadon S, Gupta N, Sigouros M, Khani F, Poutanen M, Zoubeidi A, Beltran H, Palanisamy N, Ateeq B
A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions (2020)
- Scientific Data
Gabriel M, Fey V, Heinosalo T, Adhikari P, Rytkönen K, Komulainen T, Huhtinen K, Laajala TD, Siitari H, Virkki A, Suvitie P, Kujari H, Aittokallio T, Perheentupa A, Poutanen M
Erbb4 regulates the oocyte microenvironment during folliculogenesis (2020)
- Human Molecular Genetics
Veikkolainen V, Ali N, Doroszko M, Kiviniemi A, Miinalainen I, Ohlsson C, Poutanen M, Rahman N, Elenius K, Vainio SJ, Naillat F
Exploratory Analysis of CA125-MGL and –STn Glycoforms in the Differential Diagnostics of Pelvic Masses (2020)
- The Journal of Applied Laboratory Medicine
Liina Salminen, Nimrah Nadeem, Anne Lone Rolfsen, Anne Dørum, Teemu D Laajala, Seija Grènman, Sakari Hietanen, Taija Heinosalo, Antti Perheentupa, Matti Poutanen, Nils Bolstad, Olli Carpén, Urpo Lamminmäki, Kim Pettersson, Kamlesh Gidwani, Johanna Hynninen, Kaisa Huhtinen
Genetic Ablation of MiR-22 Fosters Diet-Induced Obesity and NAFLD Development (2020)
- Journal of Personalized Medicine
Gjorgjieva Monika, Sobolewski Cyril, Ay Anne-Sophie, Abegg Daniel, de Sousa Marta Correia, Portius Dorothea, Berthou Flavien, Fournier Margot, Maeder Christine, Rantakari Pia, Zhang Fu-Ping, Poutanen Matti, Picard Didier, Montet Xavier, Nef Serge, Adibekian Alexander, Foti Michelangelo
Glycovariant-based lateral flow immunoassay to detect ovarian cancer–associated serum CA125 (2020)
- Communications Biology
Sherif Bayoumy, Heidi Hyytiä, Janne Leivo, Sheikh M. Talha, Kaisa Huhtinen, Matti Poutanen, Johanna Hynninen, Antti Perheentupa, Urpo Lamminmäki, Kamlesh Gidwani & Kim Pettersson
Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice (2020)
- American Journal of Physiology : Endocrinology and Metabolism
Heikelä Hanna, Ruohonen Suvi T, Adam Marion, Viitanen Riikka, Liljenbäck Heidi, Eskola Olli, Gabriel Michael, Mairinoja Laura, Pessia Alberto, Velagapudi Vidya, Roivainen Anne, Zhang Fu-Ping, Strauss Leena, Poutanen Matti
Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice (2020)
- Scientific Reports
Aguilar-Pimentel J.A., Cho Y.L., Gerlini R., Calzada-Wack J., Wimmer M., Mayer-Kuckuk P., Adler T., Schmidt-Weber C.B., Busch D.H., Fuchs H., Gailus-Durner V., Ollert M., Hrabě de Angelis M., Ohlsson C., Poutanen M., Teperino R., Strauss L.

CURRENTPOSITIONS

CURRENT
POSITIONS