Matti Poutanen
PhD
matpou@utu.fi +358 29 450 2632 +358 50 366 0140 Kiinamyllynkatu 10 Turku : C507 : https://orcid.org/000-0002-8953-1734 |
gentically modified mice, sex steroids, endometriosis, hormonal cancer
EDUCATIONAL
TRAINING
1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland
1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland
1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland
CURRENT
POSITIONS
Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland
Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden
MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry
SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.
SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK
Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)
Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.
Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging
2 of 10
- Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression (2023)
- BMC Medicine
- Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer (2023)
- Oncogenesis
- Persistently expressed human chorionic gonadotropin induces premature luteinization and progressive alterations on the reproductive axis in female mice (2023)
- General and Comparative Endocrinology
- Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men (2023)
- Journal of Clinical Endocrinology and Metabolism
- Targeting sex steroid biosynthesis for breast and prostate cancer therapy (2023)
- Nature Reviews Cancer
- The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression (2023)
- FASEB BioAdvances
- AKR1D1 knockout mice develop a sex-dependent metabolic phenotype (2022)
- Journal of Endocrinology
- Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2022)
- Reproduction
- Comprehensive Sex Steroid Profiling in Multiple Tissues Reveals Novel Insights in Sex Steroid Distribution in Male Mice (2022)
- Endocrinology
- Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function (2022)
- Thyroid
- Dehydroepiandrosterone Supplementation Results in Varying Tissue-specific Levels of Dihydrotestosterone in Male Mice (2022)
- Endocrinology
- Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice (2022)
- Nature Communications
- High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice (2022)
- iScience
- Histone H3K4me3 breadth in hypoxia reveals endometrial core functions and stress adaptation linked to endometriosis (2022)
- iScience
- Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis (2022)
- International Journal of Molecular Sciences
- Low Progesterone and Low Estradiol Levels Associate with Abdominal Aortic Aneurysms in Men (2022)
- Journal of Clinical Endocrinology and Metabolism
- Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice (2022)
- International Journal of Molecular Sciences
- Physiological levels of estradiol limit murine osteoarthritis progression (2022)
- Journal of Endocrinology
- Preterm infant circulating sex steroid levels are not altered by transfusion with adult male plasma: a retrospective multicentre cohort study (2022)
- Archives of Disease in Childhood Fetal and Neonatal Edition
- Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure (2022)
- Human Reproduction
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