Georgy Belogurov
PhD
gebelo@utu.fi +358 29 450 4775 +358 50 475 7149 Tykistökatu 6 Turku Työhuone: 6057 ORCID-tunniste: https://orcid.org/0000-0002-3070-6843 |
Transcription, nucleic acids enzymes, enzyme kinetics, protein chemistry, molecular modeling, nucleoside analogue inhibitors, phylogenomics.
Ph.D. - University of Turku, Dept. of Biochemistry, Finland, 2005
Postdoc - Ohio State Univesity, Dept. of Microbiology, USA, 2006-2009
Principal investigator - University of Turku, Dept. of Biochemistry, Finland, 2009-2020
Principal investigator - University of Turku, Dept. of Life Technologies, Finland, 2020-
Associate Professor - University of Turku, Dept. of Life Technologies, Finland, 2023-
The properties of a cell are determined by the information encoded in its genome. Understanding how such information is differentially and dynamically retrieved in response to environmental changes and cellular needs is a major challenge facing molecular biology. The focal point of our research is a multisubunit RNA polymerase, the enzyme that carries out the first step in gene expression, synthesis of RNA. We study several classes of RNA polymerases with the aim of understanding the fundamental aspects of transcription regulation, catalytic mechanism, and developing medically relevant transcription inhibitors.
Molecular Biology, Bioproduction, Bioinformatics, Enzyme kinetics
- Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Oxazinomycin arrests RNA polymerase at the polythymidine sequences (2019)
- Nucleic Acids Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The Mechanisms of Substrate Selection, Catalysis, and Translocation by the Elongating RNA Polymerase (2019)
- Journal of Molecular Biology
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Active site closure stabilizes the backtracked state of RNA polymerase (2018)
- Nucleic Acids Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Locking the nontemplate DNA to control transcription (2018)
- Molecular Microbiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Structural basis of RNA polymerase I stalling at UV light-induced DNA damage (2018)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Uneven Braking Spins RNA Polymerase into a Pause (2018)
- Molecular Cell
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics (2017)
- ACS Chemical Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - GreA and GreB Enhance Expression of Escherichia coli RNA Polymerase Promoters in a Reconstituted Transcription–Translation System (2016)
- ACS Synthetic Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Lineage-specific variations in the trigger loop modulate RNA proofreading by bacterial RNA polymerases (2016)
- Nucleic Acids Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
