Docent Jarkko Koivunen - UTU Research Portal

Jarkko Koivunen
Docent

Research Manager, MediCity Research Laboratory (Faculty of Medicine)

jarkko.koivunen@utu.fi

+358 29 450 4927

+358 50 449 4932

Tykistökatu 6

Turku

ORCID identifier: https://orcid.org/0000-0001-8060-555X

Areas of expertise

Academia – Industry collaboration; Academia – Industry funding; drug discovery; cell signaling; research funding

Biography

I obtained my masters in organic chemistry in 2007 and my PhD in cellular and molecular biology in 2011, both from the University of Jyväskylä. After finishing my doctorate, I moved to Oulu where I worked as a researcher over ten years. I have been a research manager of InFLAMES flagship since January 2022.

I have good industrial and academic networks varying from high content screening to cancer research. I have been preparing and writing consortium and other big international applications, seeking new partners, commenting on the application texts and participating in other tasks related to compiling the funding applications.

Publications

Analysis of extracellular matrix network dynamics in cancer using the MatriNet database (2022)
- Matrix Biology
Kontio J, Sonora VR, Pesola V, Lamba R, Dittmann A, Navarro AD, Koivunen J, Pihlajaniemi T, Izzi V
(Refereed journal article or data article (A1))
Identification of suitable reference genes for normalization of reverse transcription quantitative real-time PCR (RT-qPCR) in the fibrotic phase of the bleomycin mouse model of pulmonary fibrosis. (2022)
- PLoS ONE
O Norman , Koivunen Jarkko , JM Mäki , T Pihlajaniemi , Heikkinen Anne
(Refereed journal article or data article (A1))
The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis (2022)
- Scientific Reports
Kemppainen A, Finnilä M, Heikkinen A, Härönen H, Izzi V, Kauppinen S, Saarakkala S, Pihlajaniemi T, Koivunen J
(Refereed journal article or data article (A1))
Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis (2022)
- Frontiers in Oncology
Martínez-Nieto GA, Teppo HR, Petrelius N, Izzi V, Devarajan R, Petäistö T, Liu H, Kim KS, Karppinen SM, Ruotsalainen H, Koivunen J, Mäki JM, Walker GC, Pihlajaniemi T, Gullberg D, Heljasvaara R
(Refereed journal article or data article (A1))
Integrin alpha 11 beta 1 is a receptor for collagen XIII (2021)
- Cell and Tissue Research
Koivunen J, Tu H, Kemppainen A, Anbazhagan P, Finnila MA, Saarakkala S, Kapyla J, Lu N, Heikkinen A, Juffer AH, Heino J, Gullberg D, Pihlajaniemi T
(Refereed journal article or data article (A1))
The Burden of Post-Translational Modification (PTM)-Disrupting Mutations in the Tumor Matrisome (2021)
- Cancers
Holstein E, Dittmann A, Kaariainen A, Pesola V, Koivunen J, Pihlajaniemi T, Naba A, Izzi V
(Refereed journal article or data article (A1))
Exploring the roles of MACIT and multiplexin collagens in stem cells and cancer (2020)
- Seminars in Cancer Biology
Izzi V, Heljasvaara R, Heikkinen A, Karppinen SM, Koivunen J, Pihlajaniemi T
(Refereed journal article or data article (A1))
Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis (2020)
- Journal of Physiology
Petaisto T, Vicente D, Makela KA, Finnila MA, Miinalainen I, Koivunen J, Izzi V, Aikio M, Karppinen SM, Devarajan R, Thevenot J, Herzig KH, Heljasvaara R, Pihlajaniemi T
(Refereed journal article or data article (A1))
Machine Learning Identifies Robust Matrisome Markers and Regulatory Mechanisms in Cancer (2020)
- International Journal of Molecular Sciences
Kaariainen A, Pesola V, Dittmann A, Kontio J, Koivunen J, Pihlajaniemi T, Izzi V
(Refereed journal article or data article (A1))
Collagen XIII-derived ectodomain regulates bone angiogenesis and intracortical remodeling (2019)
- Matrix Biology
Koivunen J, Kemppainen AV, Finnila MA, Keski-Filppula R, Haronen H, Tu HM, Pellikka H, Heikkinen A, Kylmaoja E, Sormunen R, Miinalainen I, Saarakkala S, Izzi V, Pihlajaniemi T
(Refereed journal article or data article (A1))
2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors (2018)
- Scientific Reports
Nkizinkiko Y, Desantis J, Koivunen J, Haikarainen T, Murthy S, Sancineto L, Massari S, Ianni F, Obaji E, Loza MI, Pihlajaniemi T, Brea J, Tabarrini O, Lehtio L
(Refereed journal article or data article (A1))
The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated (2018)
- Biochemical Journal
Kaur I, Ruskamo S, Koivunen J, Heljasvaara R, Lackman JJ, Izzi V, Petaja-Repo UE, Kursula P, Pihlajaniemi T
(Refereed journal article or data article (A1))
Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity (2017)
- Journal of Medicinal Chemistry
Nathubhai A, Haikarainen T, Koivunen J, Murthy S, Koumanov F, Lloyd MD, Holman GD, Pihlajaniemi T, Tosh D, Lehtio L, Threadgill MD
(Refereed journal article or data article (A1))
Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage (2016) Venkannagari H, Verheugd P, Koivunen J, Haikarainen T, Obaji E, Ashok Y, Narwal M, Pihlajaniemi T, Luscher B, Lehtio L
(Refereed journal article or data article (A1))
Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics (2015)
- Bioorganic and Medicinal Chemistry
Nkizinkiko Y, Kumar BVSS, Jeankumar VU, Haikarainen T, Koivunen J, Madhuri C, Yogeeswari P, Venkannagari H, Obaji E, Pihlajaniemi T, Sriram D, Lehtio L
(Refereed journal article or data article (A1))
Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity (2013)
- Journal of Medicinal Chemistry
Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtio L
(Refereed journal article or data article (A1))
para-Substituted 2-Phenyl-3,4-dihydroquinazolin-4-ones As Potent and Selective Tankyrase Inhibitors (2013)
- ChemMedChem
Haikarainen T, Koivunen J, Narwal M, Venkannagari H, Obaji E, Joensuu P, Pihlajaniemi T, Lehtio L
(Refereed journal article or data article (A1))
Novel alpha 2 beta 1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation (2012)
- Journal of Biological Chemistry
Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K, Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J
(Refereed journal article or data article (A1))
Blockage of collagen binding to integrin alpha 2 beta 1: structure-activity relationship of protein-protein interaction inhibitors (2011)
- MedChemComm
Koivunen JT, Nissinen L, Juhakoski A, Pihlavisto M, Marjamaki A, Huuskonen J, Pentikainen OT
(Refereed journal article or data article (A1))
Fluorescent Small Molecule Probe to Modulate and Explore alpha 2 beta 1 Integrin Function (2011)
- Journal of the American Chemical Society
Koivunen JT, Nissinen L, Kapyla J, Jokinen J, Pihlavisto M, Marjamaki A, Heino J, Huuskonen J, Pentikainen OT
(Refereed journal article or data article (A1))