Aleksi Tornio - UTU Research Portal

Aleksi Tornio

- Associate Professor,
Institute of Biomedicine (Faculty of Medicine)

aleksi.tornio@utu.fi

+358 29 450 4608

+358 50 476 5715

Kiinamyllynkatu 10

Turku

: https://orcid.org/0000-0001-5713-5692

Clinical Pharmacology; Pharmacokinetics; Drug-drug interactions; Pharmacogenetics

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Placental transporter-mediated drug interactions and offspring congenital anomalies (2020)
- British Journal of Clinical Pharmacology
Maria Ellfolk, Aleksi Tornio, Mikko Niemi, Maarit K. Leinonen, Anna‐Maria Lahesmaa‐Korpinen, Heli Malm
UGT1A3 and Sex Are Major Determinants of Telmisartan Pharmacokinetics-A Comprehensive Pharmacogenomic Study (2020)
- Clinical Pharmacology and Therapeutics
Hirvensalo P, Tornio A, Launiainen T, Paile-Hyvarinen M, Tapaninen T, Neuvonen M, Backman JT, Niemi M
Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation (2019)
- Clinical Pharmacology and Therapeutics
Tornio A, Filppula AM, Niemi M, Backman JT
Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans (2019)
- Drug Metabolism and Disposition
Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT
Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel (2019)
- Clinical Pharmacology and Therapeutics
Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT
CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel (2019)
- Clinical Pharmacology and Therapeutics
Holmberg MT, Tornio A, Paile-Hyvarinen M, Tarkiainen EK, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M
Enantiospecific Pharmacogenomics of Fluvastatin (2019)
- Clinical Pharmacology and Therapeutics
Hirvensalo P, Tornio A, Neuvonen M, Kiander W, Kidron H, Paile-Hyvarinen M, Tapaninen T, Backman JT, Niemi M
Farmakogenetiikan merkitys lääkehoidolle (2019) Lääketieteellinen farmakologia ja toksikologia Mikko Niemi, Miia Turpeinen, Aleksi Tornio
Farmakokinetiikkaan vaikuttavat perintötekijät (2019) Lääketieteellinen farmakologia ja toksikologia Mikko Niemi, Miia Turpeinen, Aleksi Tornio
Itraconazole Increases Ibrutinib Exposure 10-Fold and Reduces Interindividual Variation-A Potentially Beneficial Drug-Drug Interaction (2019)
- Clinical and Translational Science
Tapaninen T, Olkkola AM, Tornio A, Neuvonen M, Elonen E, Neuvonen PJ, Niemi M, Backman JT
Muut lääkevasteeseen vaikuttavat perintötekijät (2019) Lääketieteellinen farmakologia ja toksikologia Mikko Niemi, Miia Turpeinen, Aleksi Tornio
Response to "Interaction of Dasabuvir With Clopidogrel: Did Predictions by Physiologically Based Pharmacokinetics Modeling Pass the Test?" (2019) Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT
Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans (2018)
- Clinical Pharmacology and Therapeutics
Itkonen MK, Tornio A, Filppula AM, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT
Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions (2018)
- Drug Metabolism and Disposition
Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT
Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics (2018)
- Clinical Pharmacology and Therapeutics
Hirvensalo P, Tornio A, Neuvonen M, Tapaninen T, Paile-Hyvarinen M, Karja V, Mannisto VT, Pihlajamaki J, Backman JT, Niemi M
Cytochrome P450 in Pharmacogenetics: An Update (2018)
- Advances in Pharmacology
Tornio A, Backman JT
Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects (2018)
- Basic and Clinical Pharmacology and Toxicology
Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvarinen M, Itkonen MK, Holmberg MT, Karja V, Mannisto VT, Neuvonen PJ, Pihlajamaki J, Backman JT, Niemi M
Implications of intercorrelation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: a case study with repaglinide (2018)
- British Journal of Clinical Pharmacology
Doki K, Darwich AS, Achour B, Tornio A, Backman JT, Rostami-Hodjegan A
Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records (2018)
- Clinical Pharmacology and Therapeutics
Tornio A, Flynn R, Morant S, Velten E, Palmer CNA, MacDonald TM, Doney ASF
Response to "Influence of Diabetes on Antiplatelet Drug Efficacy" (2018) Tornio A, Palmer CNA, Doney ASF