Aleksi Tornio - UTU Research Portal

Aleksi Tornio

- Associate Professor,
Institute of Biomedicine (Faculty of Medicine)

aleksi.tornio@utu.fi

+358 29 450 4608

+358 50 476 5715

Kiinamyllynkatu 10

Turku

ORCID identifier: https://orcid.org/0000-0001-5713-5692

Areas of expertise

Clinical Pharmacology; Pharmacokinetics; Drug-drug interactions; Pharmacogenetics

Publications

8 of 9

Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin (2015)
- Drug Metabolism and Disposition
Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT
(A1 Refereed original research article in a scientific journal)
Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril (2015)
- British Journal of Clinical Pharmacology
Tarkiainen EK, Tornio A, Holmberg MT, Launiainen T, Neuvonen PJ, Backman JT, Niemi M
(A1 Refereed original research article in a scientific journal)
Effect of grapefruit juice on the bioactivation of prasugrel (2015)
- British Journal of Clinical Pharmacology
Holmberg MT, Tornio A, Hyvarinen H, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M
(A1 Refereed original research article in a scientific journal)
SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid (2015)
- Pharmacogenetics and Genomics
Tornio A, Vakkilainen J, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M
(A1 Refereed original research article in a scientific journal)
Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions (2014)
- Clinical Pharmacology and Therapeutics
Tornio A, Filppula AM, Kailari O, Neuvonen M, Nyronen TH, Tapaninen T, Neuvonen PJ, Niemi M, Backman JT
(A1 Refereed original research article in a scientific journal)
Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel (2014)
- Clinical Pharmacology and Therapeutics
Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M
(A1 Refereed original research article in a scientific journal)
Gemfibrozil Impairs lmatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite (2013)
- Clinical Pharmacology and Therapeutics
Filppula AM, Tornio A, Niemi M, Neuvonen PJ, Backman JT
(A1 Refereed original research article in a scientific journal)
Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects (2013)
- British Journal of Clinical Pharmacology
Holmberg MT, Tornio A, Joutsi-Korhonen L, Neuvonen M, Neuvonen PJ, Lassila R, Niemi M, Backman JT
(A1 Refereed original research article in a scientific journal)
Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications (2012)
- Trends in Pharmacological Sciences
Tornio A, Niemi M, Neuvonen PJ, Backman JT
(A2 Refereed review article in a scientific journal )
CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe (2009)
- Drug Metabolism and Disposition
Backman JT, Honkalammi J, Neuvonen M, Kurkinen KJ, Tornio A, Niemi M, Neuvonen PJ
(A1 Refereed original research article in a scientific journal)