Aleksi Tornio - UTU Research Portal

Aleksi Tornio

- Associate Professor,
Institute of Biomedicine (Faculty of Medicine)

aleksi.tornio@utu.fi

+358 29 450 4608

+358 50 476 5715

Kiinamyllynkatu 10

Turku

ORCID identifier: https://orcid.org/0000-0001-5713-5692

Areas of expertise

Clinical Pharmacology; Pharmacokinetics; Drug-drug interactions; Pharmacogenetics

Publications

4 of 5

A commonmissense variant of LILRB5 is associated with statin intolerance andmyalgia (2017)
- European Heart Journal
Siddiqui MK, Maroteau C, Veluchamy A, Tornio A, Tavendale R, Carr F, Abelega NU, Carr D, Bloch K, Hallberg P, Yue QY, Pearson ER, Colhoun HM, Morris AD, Dow E, George J, Pirmohamed M, Ridker PM, Doney ASF, Alfirevic A, Wadelius M, Maitland-van der Zee AH, Chasman DI, Palmer CNA
(A1 Refereed original research article in a scientific journal)
Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters (2017)
- Expert Opinion on Drug Metabolism and Toxicology
Tornio A, Neuvonen PJ, Niemi M, Backman JT
(A2 Refereed review article in a scientific journal )
Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone (2016)
- Drug Metabolism and Disposition
Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT
(A1 Refereed original research article in a scientific journal)
High Frequency of CYP2D6 Ultrarapid Metabolizer Genotype in the Finnish Population (2016)
- Basic and Clinical Pharmacology and Toxicology
Pietarinen P, Tornio A, Niemi M
(A1 Refereed original research article in a scientific journal)
Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans (2015)
- Clinical Pharmacology and Therapeutics
Tarkiainen EK, Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M
(A1 Refereed original research article in a scientific journal)
Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin (2015)
- Drug Metabolism and Disposition
Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT
(A1 Refereed original research article in a scientific journal)
Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril (2015)
- British Journal of Clinical Pharmacology
Tarkiainen EK, Tornio A, Holmberg MT, Launiainen T, Neuvonen PJ, Backman JT, Niemi M
(A1 Refereed original research article in a scientific journal)
Effect of grapefruit juice on the bioactivation of prasugrel (2015)
- British Journal of Clinical Pharmacology
Holmberg MT, Tornio A, Hyvarinen H, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M
(A1 Refereed original research article in a scientific journal)
SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid (2015)
- Pharmacogenetics and Genomics
Tornio A, Vakkilainen J, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M
(A1 Refereed original research article in a scientific journal)
Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug-Drug Interactions (2014)
- Clinical Pharmacology and Therapeutics
Tornio A, Filppula AM, Kailari O, Neuvonen M, Nyronen TH, Tapaninen T, Neuvonen PJ, Niemi M, Backman JT
(A1 Refereed original research article in a scientific journal)
Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel (2014)
- Clinical Pharmacology and Therapeutics
Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M
(A1 Refereed original research article in a scientific journal)
Gemfibrozil Impairs lmatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite (2013)
- Clinical Pharmacology and Therapeutics
Filppula AM, Tornio A, Niemi M, Neuvonen PJ, Backman JT
(A1 Refereed original research article in a scientific journal)
Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects (2013)
- British Journal of Clinical Pharmacology
Holmberg MT, Tornio A, Joutsi-Korhonen L, Neuvonen M, Neuvonen PJ, Lassila R, Niemi M, Backman JT
(A1 Refereed original research article in a scientific journal)
Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications (2012)
- Trends in Pharmacological Sciences
Tornio A, Niemi M, Neuvonen PJ, Backman JT
(A2 Refereed review article in a scientific journal )
CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe (2009)
- Drug Metabolism and Disposition
Backman JT, Honkalammi J, Neuvonen M, Kurkinen KJ, Tornio A, Niemi M, Neuvonen PJ
(A1 Refereed original research article in a scientific journal)
The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: Evidence for mechanism-based inhibition of CYP2C8 in vivo (2008)
- Clinical Pharmacology and Therapeutics
Tornio A, Niemi M, Neuvonen M, Laitila J, Kalliokoski A, Neuvonen PJ, Backman JT
(A1 Refereed original research article in a scientific journal)
Trimethoprim and the CYP2C8*3 allele have opposite effects on the pharmacokinetics of pioglitazone (2008)
- Drug Metabolism and Disposition
Tornio A, Niemi M, Neuvonen PJ, Backman JT
(A1 Refereed original research article in a scientific journal)
Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen (2007)
- European Journal of Clinical Pharmacology
Tornio A, Niemi M, Neuvonen PJ, Backman JT
(A1 Refereed original research article in a scientific journal)
Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide (2006)
- European Journal of Clinical Pharmacology
Niemi M, Tornio A, Pasanen MK, Fredrikson H, Neuvonen PJ, Backman JT
(A1 Refereed original research article in a scientific journal)
The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone (2006)
- European Journal of Clinical Pharmacology
Tornio A, Neuvonen PJ, Backman JT
(A1 Refereed original research article in a scientific journal)