Virpi Talman
PhD (Pharm), Title of Docent
virpi.talman@utu.fi +358 29 450 2952 +358 50 590 6676 Office: C639 ORCID identifier: https://orcid.org/0000-0002-2702-6505 |
Publications 
2 of 3
- Doxorubicin-Induced Cardiotoxicity and Novel GATA4-Targeted Compounds (2019) Karhu ST, Kinnunen S, Talman V, Ruskoaho H
(A4 Refereed article in a conference publication ) - Structure-activity relationship-guided synthesis and identification of the GATA4 and NKX2-5 protein-protein interaction modulators (2019) Jumppanen M, Kinnunen S, Välimäki M, Auno S, Boije af Gennäs G, Xhaard H, Talman V, Ruskoaho H, Yli-Kauhaluoma J
(A1 Refereed original research article in a scientific journal) - Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators (2019)
- Journal of Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - The Role of Protein Kinase C Isoforms in Cardiomyocyte Hypertrophy (2019) Pohjolainen L, Solanki R, Ruskoaho H, Talman V
(A4 Refereed article in a conference publication ) - Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer (2018)
- FEBS Open Bio
(A1 Refereed original research article in a scientific journal) - Cardiomyocyte—Endothelial Cell Interactions in Cardiac Remodeling and Regeneration (2018)
- Frontiers in Cardiovascular Medicine
(A2 Refereed review article in a scientific journal ) - Dual‐drug delivery using dextran‐functionalized nanoparticles targeting cardiac fibroblasts for cellular reprogramming (2018)
- Advanced Functional Materials
(A1 Refereed original research article in a scientific journal) - Identification of cardiomyocyte-specific lncRNAs as potential regulators of cardiac regeneration (2018)
- Cardiovascular Research
(A4 Refereed article in a conference publication ) - Molecular atlas of postnatal mouse heart development (2018)
- Journal of the American Heart Association
(A1 Refereed original research article in a scientific journal) - Protein kinase C-activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations (2018)
- Neuropharmacology
(A1 Refereed original research article in a scientific journal) - Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C (2018)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds (2018)
- Archives of Toxicology
(A1 Refereed original research article in a scientific journal) - Toxicity profiling of cardiac transcription factor-targeted compounds in various cardiac and stem cell types reveals cell type-and compound-dependent toxicity (2018)
- Cardiovascular Research
(A4 Refereed article in a conference publication ) - Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5 (2017)
- Journal of Medicinal Chemistry
(A1 Refereed original research article in a scientific journal) - Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (2017)
- Small
(A1 Refereed original research article in a scientific journal) - Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration (2016)
- Cell and Tissue Research
(A2 Refereed review article in a scientific journal ) - Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins? (2016)
- Basic and Clinical Pharmacology and Toxicology
(A2 Refereed review article in a scientific journal ) - Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands (2015)
- MedChemComm
(A1 Refereed original research article in a scientific journal) - C1 domain-targeted isophthalates as protein kinase C modulators: Structure-based design, structure-activity relationships and biological activities (2014)
- Biochemical Society Transactions
(A2 Refereed review article in a scientific journal ) - Evidence for a role of MRCK in mediating He La cell elongation induced by the Cl domain ligand HMI-1a3 (2014)
- European Journal of Pharmaceutical Sciences
(A1 Refereed original research article in a scientific journal)
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