PhD (Pharm), Title of Docent Virpi Talman - UTU Research Portal

Virpi Talman
PhD (Pharm), Title of Docent

- Associate Professor,
Institute of Biomedicine (Faculty of Medicine)

virpi.talman@utu.fi

+358 29 450 2952

+358 50 590 6676

Office: C639

ORCID identifier: https://orcid.org/0000-0002-2702-6505

ResearchGate

ORCiD

Publications

1 of 3

Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling (2025)
- Journal of the American Heart Association
Suominen, Anni; Suni, Aino; Ruohonen, Saku; Szabó, Zoltán; Pohjolainen, Lotta; Cai, Minying; Savontaus, Eriika; Talman, Virpi; Kerkelä, Risto; Rinne, Petteri
(A1 Refereed original research article in a scientific journal)
Melt electrowritten medium chain length polyhydroxyalkanoate cardiac patches for Post-MI cardiac regeneration (2025)
- Materials Today Bio
Majid, Qasim A.; Pandey, Pragati; Bellahcene, Mohamed; Grigsby, Christopher L.; Stevens, Molly M.; Talman, Virpi; Stuckey, Daniel J.; Harding, Sian E.; Roy, Ipsita; Foldes, Gabor
(A1 Refereed original research article in a scientific journal)
Tissue-Inducing Biomaterials for Cardiac Tissue Regeneration and Repair (2025)
- Tissue Engineering Part A
Shafiq, Muhammad; Majid, Qasim A.; Rafique, Muhammad; Talman, Virpi
(A2 Refereed review article in a scientific journal )
Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound (2024)
- Stem cell research & therapy
Pohjolainen, Lotta; Kinnunen, Sini M.; Auno, Samuli; Kiriazis, Alexandros; Pohjavaara, Saana; Kari-Koskinen, Julia; Zore, Matej; Jumppanen, Mikael; Yli-Kauhaluoma, Jari; Talman, Virpi; Ruskoaho, Heikki; Valimaki, Mika J.
(A1 Refereed original research article in a scientific journal)
α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor (2024)
- EMBO Reports
Suominen Anni, Saldo Rubio Guillem, Ruohonen Saku, Szabó Zoltan, Pohjolainen Lotta, Ghimire Bishwa, Ruohonen Suvi T., Saukkonen Karla, Ijas Jani, Skarp Sini, Kaikkonen Leena, Cai Minying, Wardlaw Sharon L., Ruskoaho Heikki, Talman Virpi, Savontaus Eriika, Kerkelä Risto, Rinne Petteri
(A1 Refereed original research article in a scientific journal)
Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists (2023)
- Journal of Medicinal Chemistry
Lautala, Saara; Provenzani, Riccardo; Tarvainen, Ilari; Sirna, Katia; Karhu, S. Tuuli; Grazhdankin, Evgeni; Lehtinen, Antti K.; Sa'd, Hanan; Koivuniemi, Artturi; Xhaard, Henri; Tuominen, Raimo K.; Talman, Virpi; Bunker, Alex; Yli-Kauhaluoma, Jari
(A1 Refereed original research article in a scientific journal)
Application of Human Induced Pluripotent Stem Cell Technology for Cardiovascular Regenerative Pharmacology (2022) Induced Pluripotent Stem (iPS) Cells Majid Q, Orsolits B, Pohjolainen L, Kovacs Z, Kovács Z, Földes G, Talman V
(A2 Refereed review article in a scientific journal )
Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. (2022)
- Journal of Physiology
Huethorst E, Mortensen P, Simitev {D, Gao H, Pohjolainen L, Talman V, Ruskoaho H, Burton {L, Gadegaard N, Smith {L
(A1 Refereed original research article in a scientific journal)
In vitro Evaluation of the Therapeutic Effects of Dual-Drug Loaded Spermine-Acetalated Dextran Nanoparticles Coated with Tannic Acid for Cardiac Applications (2022)
- Advanced Functional Materials
Torrieri, Giulia; Ferreira, Monica P. A.; Shahbazi, Mohammad-Ali; Talman, Virpi; Karhu, S. Tuuli; Pohjolainen, Lotta; Carvalho, Claudia; Pinto, Joao F.; Hirvonen, Jouni; Ruskoaho, Heikki; Balasubramanian, Vimalkumar; Santos, Helder A.
(A1 Refereed original research article in a scientific journal)
Protein Kinase A-Mediated Effects of Protein Kinase C Partial Agonist 5-(Hydroxymethyl)Isophthalate 1a3 in Colorectal Cancer (2022)
- Journal of Pharmacology and Experimental Therapeutics
Tarvainen, Ilari; Nunn, Rebecca C.; Tuominen, Raimo K.; Jantti, Maria H.; Talman, Virpi
(A1 Refereed original research article in a scientific journal)
Transcriptomics reveal stretched human pluripotent stem cell-derived cardiomyocytes as an advantageous hypertrophy model (2022)
- Journal of molecular and cellular cardiology plus
Pohjolainen, Lotta; Ruskoaho, Heikki; Talman, Virpi
(A1 Refereed original research article in a scientific journal)
Distinct Regulation of Cardiac Fibroblast Proliferation and Transdifferentiation by Classical and Novel Protein Kinase C Isoforms: Possible Implications for New Antifibrotic Therapies (2021)
- Molecular Pharmacology
Karhu, S. Tuuli; Ruskoaho, Heikki; Talman, Virpi
(A1 Refereed original research article in a scientific journal)
Mullistaako sydämen regeneraation mekanismien tutkimus sydäninfarktin jälkeisen lääkehoidon tulevaisuudessa? (2021)
- Sydänääni: Suomen Kardiologisen Seuran Lehti
Talman Virpi
(A2 Refereed review article in a scientific journal )
Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (2021)
- Frontiers in Pharmacology
Pohjolainen, Lotta; Easton, Julia; Solanki, Reesha; Ruskoaho, Heikki; Talman, Virpi
(A1 Refereed original research article in a scientific journal)
Cell adhesion and proliferation on common 3D printing materials used in stereolithography of microfluidic devices (2020)
- Lab on a Chip
Piironen K, Haapala M, Talman V, Järvinen P, Sikanen T
(A1 Refereed original research article in a scientific journal)
Dual-peptide functionalized acetalated dextran-based nanoparticles for sequential targeting of macrophages during myocardial infarction (2020)
- Nanoscale
Torrieri, Giulia; Fontana, Flavia; Figueiredo, Patricia; Liu, Zehua; Ferreira, Monica P. A.; Talman, Virpi; Martins, Joao P.; Fusciello, Manlio; Moslova, Karina; Teesalu, Tambet; Cerullo, Vincenzo; Hirvonen, Jouni; Ruskoaho, Heikki; Balasubramanian, Vimalkumar; Santos, Helder A.
(A1 Refereed original research article in a scientific journal)
GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes (2020)
- Archives of Toxicology
Karhu, S. Tuuli; Kinnunen, Sini M.; Tolli, Marja; Valimaki, Mika J.; Szabo, Zoltan; Talman, Virpi; Ruskoaho, Heikki
(A1 Refereed original research article in a scientific journal)
Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics (2020)
- ACS Medicinal Chemistry Letters
Tarvainen, Ilari; Zimmermann, Tomas; Heinonen, Pia; Jantti, Maria Helena; Yli-Kauhaluoma, Jari; Talman, Virpi; Franzyk, Henrik; Tuominen, Raimo K.; Christensen, Soren Brogger
(A1 Refereed original research article in a scientific journal)
Rigorous Computational Study Reveals What Docking Overlooks: Double Trouble from Membrane Association in Protein Kinase C Modulators (2020)
- Journal of Chemical Information and Modeling
Lautala, Saara; Provenzani, Riccardo; Koivuniemi, Artturi; Kulig, Waldemar; Talman, Virpi; Rog, Tomasz; Tuominen, Raimo K.; Yli-Kauhaluoma, Jari; Bunker, Alex
(A1 Refereed original research article in a scientific journal)
A potent partial agonist of PKC orients in membranes like the biological activator diacylglycerol (2019)
- European Biophysics Journal
Lautala, S.; Koivuniemi, A.; Kulig, W.; Rog, T.; Talman, V.; Tuominen, R.; Bunker, A.
(A1 Refereed original research article in a scientific journal)