Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID identifier: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Consensus recommendations on the use of 18F-FDG PET/CT in lung diseaseRegional Renal Hemodynamics and Fatty Acid Uptake: Effects of Obesity and Weight Loss (2020)
- Journal of Nuclear MedicineDiabetes
(A1 Refereed original research article in a scientific journal) - Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathyMagnetic Resonance-Based Attenuation Correction and Scatter Correction in Neurological Positron Emission Tomography/Magnetic Resonance Imaging—Current Status With Emerging Applications (2020)
- Journal of Cerebral Blood Flow and MetabolismFrontiers in PhysicsAmerican Journal of Physiology : Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - (2020)
(A2 Refereed review article in a scientific journal ) - Quantification Analysis of Behavioral Changes after Sciatic Nerve Ligation in RatsDysregulation of RNF213 promotes cerebral hypoperfusion (2020)
- Asia-pacific signal and information processing association annual summit and conference
(A4 Refereed article in a conference publication ) - Amyloid β deposition in subcortical stroke patients and effects of educational achievement: A pilot study (2019)
- International Journal of Geriatric Psychiatry
(A1 Refereed original research article in a scientific journal) - Detection of brain amyloid‐β deposits due to the repetitive head trauma in a former karate player (2019)
- Psychogeriatrics
(B1 Non-refereed article in a scientific journal) - Early Detection of Cerebral Infarction After Focal Ischemia Using a New MRI Indicator (2019)
- Molecular NeurobiologyMacromolecular Bioscience
(A1 Refereed original research article in a scientific journal) - Kinetic Modelling and Extraction of Metabolic Parameters (2019) Hybrid MR-PET Imaging: Systems, Methods and Applications Hans Herzog, Hidehiro Iida, Liliana Calderia
(B2 Non-refereed book chapter or chapter in a compilation book) - Vascular responses to abrupt blood flow change after bypass surgery for complex intracranial aneurysms (2019)
(Other publication) - Renal hemodynamics and fatty acid uptake: effects of obesity and weight lossBinding of C-11-Pittsburgh compound-B correlated with white matter injury in hypertensive small vessel disease (2019)
(A1 Refereed original research article in a scientific journal) - Renal vascular resistance is increased in patients with kidney transplant (2019)
- BMC Nephrology
(A1 Refereed original research article in a scientific journal) - Development of matrix metalloproteinase-targeted probes for lung inflammation detection with positron emission tomography (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - I-123-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice (2018)
- Nuclear Medicine and Molecular Imaging
(A1 Refereed original research article in a scientific journal) - One-pot enzymatic synthesis of L-[3-C-11]lactate for pharmacokinetic analysis of lactate metabolism in rat brain (2018)
- Nuclear Medicine and Biology
(A1 Refereed original research article in a scientific journal) - Superfine Magnetic Resonance Imaging of the Cerebrovasculature Using Self-Assembled Branched Polyethylene Glycol-Gd Contrast Agent (2018)
(A1 Refereed original research article in a scientific journal) - System evaluation of automated production and inhalation of O-15-labeled gaseous radiopharmaceuticals for the rapid O-15-oxygen PET examinations (2018)
- EJNMMI Physics
(A1 Refereed original research article in a scientific journal) - The renal blood flow reserve in healthy humans and patients with atherosclerotic renovascular disease measured by positron emission tomography using [O-15]H2O2018
- EJNMMI Research
(A1 Refereed original research article in a scientific journal) - (2018)
- Acta Neurochirurgica
(A1 Refereed original research article in a scientific journal) - (2017)
- Annals of Nuclear Medicine
(A1 Refereed original research article in a scientific journal)