Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID-tunniste: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Understanding of cerebral energy metabolism by dynamic living brain slice imaging system with [(18)F]FDG (2005)
- Neuroscience Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (18)F-FDG accumulation in atherosclerotic plaques: Immunohistochemical and PET imaging study (2004)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A new reconstruction strategy for image improvement in pinhole SPECT (2004)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D-2 receptors using [I-123]epidepride SPET (2004)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Endogenous dopamine release by repetitive transcranial magnetic stimulation over the primary motor cortex in anesthetized macaque monkeys (2004)
- Movement Disorders
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex: An [11]raclopride positron emission tomography study in anesthetized macaque monkeys (2004)
- Biological Psychiatry
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Long-term effect of motor cortical repetitive transcranial magnetic stimulation induces (2004)
- Annals of Neurology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Long-term effect of motor cortical repetitive transcranial magnetic stimulation induces. (vol 56, pg 77, 2004) (2004)
- Annals of Neurology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Optimization of the width of the photopeak energy window in the TDCS technique for scatter correction in quantitative SPECT (2004)
- IEEE Transactions on Nuclear Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Sinogram-based motion correction of PET images using optical motion tracking system and list-mode data acquisition (2004)
- IEEE Transactions on Nuclear Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A coil for magnetic stimulation of the macaque monkey brain (2003) Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation Nonaka Y, Hayashi T, Ohnishi T, Okabe S, Teramoto N, Ueno S, Watabe H, Matsuda H, Iida H, Ugawa Y
(A4 Vertaisarvioitu artikkeli konferenssijulkaisussa) - Activation of the anterior cingulate gyrus by 'green odor': A positron emission tomography study in the monkey (2003)
- Chemical Senses
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A theoretical model of oxygen delivery and metabolism for physiologic interpretation of quantitative cerebral blood flow and metabolic rate of oxygen (2003)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities (2003)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Dependency of energy and spatial distributions of photons on edge of object in brain SPECT (2003)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Development of a GSO detector assembly for a continuous blood sampling system (2003)
- IEEE Transactions on Nuclear Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Evaluation of penetration and scattering components in conventional pinhole SPECT: phantom studies using Monte Carlo simulation (2003)
- Physics in Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantification in SPECT cardiac imaging (2003)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The effect of nitroglycerin on myocardial blood flow in various segments characterized by rest-redistribution thallium SPECT (2003)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Validation of the dual-table autoradiographic method to quantify two sequential rCBFs in a single SPET session with N-isopropyl-[I-123]p-iodoamphetamine (2003)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )