Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID-tunniste: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Development of motion correction technique for cardiac O-15-water PET study using an optical motion tracking system (2010)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - High Resolution Brain Imaging with Combined Parallel-hole and Pinhole Collimation (2010)
- IEEE conference record - Nuclear Science Symposium & Medical Imaging Conference
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Impaired Myocardium Regeneration With Skeletal Cell Sheets-A Preclinical Trial for Tissue-Engineered Regeneration Therapy (2010)
- Transplantation
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration (2010)
- Experimental Neurology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Measurement of density and affinity for dopamine D-2 receptors by a single positron emission tomography scan with multiple injections of [C-11]raclopride (2010)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Multicenter Evaluation of a Standardized Protocol for Rest and Acetazolamide Cerebral Blood Flow Assessment Using a Quantitative SPECT Reconstruction Program and Split-Dose I-123-Iodoamphetamine (2010)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Optimization of transmission scan duration for O-15 PET study with sequential dual tracer administration using N-index (2010)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable O-15-O-2 (2010)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Slowly progressive neuronal death associated with postischemic hyperperfusion in cortical laminar necrosis after high-flow bypass for a carotid intracavernous aneurysm (2010)
- Journal of Neurosurgery
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A physiologic model for recirculation water correction in CMRO2 assessment with O-15(2) inhalation PET (2009)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Conceptual Design of High Resolution and Quantitative SPECT System for Imaging a Selected Small ROI of human brain (2009)
- IEEE conference record - Nuclear Science Symposium & Medical Imaging Conference
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction (2009)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Influence of residual oxygen-15-labeled carbon monoxide radioactivity on cerebral blood flow and oxygen extraction fraction in a dual-tracer autoradiographic method (2009)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Non-invasive estimation of hepatic glucose uptake from [F-18]FDG PET images using tissue-derived input functions (2009)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Parametric renal blood flow imaging using [O-15]H2O and PET (2009)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Performance estimation of high resolution SPECT for the human brain by Monte Carlo simulation of scintillation lights (2009)
- IEEE conference record - Nuclear Science Symposium & Medical Imaging Conference
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [C-11]raclopride (2009)
- NeuroImage
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Use of a clinical MRI scanner for preclinical research on rats (2009)
- Radiological Physics and Technology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Absolute quantitation of myocardial blood flow with Tl-201 and dynamic SPECT in canine: optimisation and validation of kinetic modelling (2008)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Acceleration of Monte Carlo-based scatter compensation for cardiac SPECT (2008)
- Physics in Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )