Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID-tunniste: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Breath-hold CT attenuation correction for quantitative cardiac SPECT (2012)
- EJNMMI Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Cerebral blood flow and metabolism of hyperperfusion after cerebral revascularization in patients with moyamoya disease (2012)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Determination of two-photon-excitation cross section for molecular isotope separation (2012)
- Journal of Molecular Spectroscopy
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Effects of patient movement on measurements of myocardial blood flow and viability in resting O-15-water PET studies (2012)
- Journal of Nuclear Cardiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - F-18 fluorodeoxyglucose uptake and water-perfusable tissue fraction in assessment of myocardial viability (2012)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Monte Carlo estimation of scatter effects on quantitative myocardial blood flow and perfusable tissue fraction using 3D-PET and O-15-water (2012)
- Physics in Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Monte Carlo simulation of scintillation photons for the design of a high-resolution SPECT detector dedicated to human brain (2012)
- Annals of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Parametric imaging of myocardial viability using O-15-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR (2012)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET (2012)
- Nuclear Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantitative assessment of regional cerebral blood flow by dynamic susceptibility contrast-enhanced MRI, without the need for arterial blood signals (2012)
- Physics in Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Reproducibility of cerebral blood flow assessment using a quantitative SPECT reconstruction program and split-dose I-123-iodoamphetamine in institutions with different gamma-cameras and collimators (2012)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The use of magnetic resonance cell tracking to monitor endothelial progenitor cells in a rat hindlimb ischemic model (2012)
- Biomaterials
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Experimental pig model of old myocardial infarction with long survival leading to chronic left ventricular dysfunction and remodeling as evaluated by PET (2011)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Long-Term In Vivo Magnetic Resonance Imaging Tracking of Endothelial Progenitor Cells Transplanted in Rat Ischemic Limbs and Their Angiogenic Potential (2011)
- Tissue Engineering: Parts A, B, and C
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Sensitivity of Kinetic Macro Parameters to Changes in Dopamine Synthesis, Storage, and Metabolism: A Simulation Study for [F-18]FDOPA PET By a Model With Detailed Dopamine Pathway (2011)
- Synapse
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and I-123-iodoamphetamine (2011)
- Nuclear Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - 3-Tesla Magnetic Resonance Angiographic Assessment of a Tissue-Engineered Small-Caliber Vascular Graft Implanted in a Rat (2010)
- Journal of Biomedical Materials Research Part B: Applied Biomaterials
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A Monte Carlo estimation of effects of activity outside field of view in O-15 cardiac 3D-PET (2010)
- IEEE conference record - Nuclear Science Symposium & Medical Imaging Conference
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Design and characterization of a polymeric MRI contrast agent based on PVA for in vivo living-cell tracking (2010)
- Contrast Media and Molecular Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Development of a high resolution and quantitative SPECT for the human brain rain (2010)
- IEEE conference record - Nuclear Science Symposium & Medical Imaging Conference
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )