Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID-tunniste: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle - Studies using [O-15]H2O, [F-18]fluoro-2-deoxy-D-glucose, and positron emission tomography (1996)
- Diabetes
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Glucose uptake in the chronically dysfunctional but viable myocardium (1996)
- Circulation
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Minimum cross-entropy reconstruction of PET images using prior anatomical information (1996)
- Physics in Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Monte Carlo and experimental evaluation of accuracy and noise properties of two scatter correction methods for SPECT (1996)
- Physics in Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Quantitative evaluation of neutral amino acid transport in cerebral gliomas using positron emission tomography and fluorine-18 fluorophenylalanine (1996)
- European Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Relationship between limb and muscle blood flow in man (1996)
- Journal of Physiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A COMPARATIVE-STUDY OF 3 FAST ALGORITHMS TO ESTIMATE CEREBRAL BLOOD-FLOW AND DISTRIBUTION VOLUME USING N-ISOPROPYL-P-[I-123]IODOAMPHETAMINE AND 2 SPECT SCANS (1995)
- Physics in Medicine and Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A FULLY-AUTOMATIC MULTIMODALITY IMAGE REGISTRATION ALGORITHM (1995)
- Journal of Computer Assisted Tomography
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - AGING EFFECT ON NEUTRAL AMINO-ACID-TRANSPORT AT THE BLOOD-BRAIN-BARRIER MEASURED WITH L-[2-F-18]-FLUOROPHENYLALANINE AND PET (1995)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - EFFECT OF REAL-TIME WEIGHTED INTEGRATION SYSTEM FOR RAPID CALCULATION OF FUNCTIONAL IMAGES IN CLINICAL POSITRON EMISSION TOMOGRAPHY (1995)
- IEEE Transactions on Medical Imaging
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - EVALUATION OF CEREBRAL INFARCTION WITH IODINE-123-IOMAZENIL SPECT (1995)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Insulin increases blood volume in human skeletal muscle: Studies using [O-15]CO and positron emission tomography (1995)
- American Journal of Physiology : Endocrinology and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - MYOCARDIAL BLOOD-FLOW - COMPARISON OF OXYGEN-15-WATER BOLUS INJECTION, SLOW INFUSION AND OXYGEN-15-CARBON DIOXIDE SLOW INHALATION (1995)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - PHOTIC-STIMULATION STUDY OF CHANGING THE ARTERIAL PARTIAL-PRESSURE LEVEL OF CARBON-DIOXIDE (1995)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - POSITRON EMISSION TOMOGRAPHY WITH O-15 OF STUNNED MYOCARDIUM CAUSED BY CORONARY-ARTERY VASOSPASM AFTER RECOVERY (1995)
- British Heart Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - RAPID CALCULATION OF REGIONAL CEREBRAL BLOOD-FLOW AND DISTRIBUTION VOLUME USING IODINE-123-IODOAMPHETAMINE AND DYNAMIC SPECT (1995)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - QUANTITATIVE MAPPING OF REGIONAL CEREBRAL BLOOD-FLOW USING IODINE-123-IMP AND SPECT (1994)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A NEW GRAPHIC PLOT ANALYSIS FOR CEREBRAL BLOOD-FLOW AND PARTITION-COEFFICIENT WITH IODINE-123-IODOAMPHETAMINE AND DYNAMIC SPECT VALIDATION STUDIES USING OXYGEN-15-WATER AND PET (1993)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - MODELING APPROACH TO ELIMINATE THE NEED TO SEPARATE ARTERIAL PLASMA IN O-15 INHALATION POSITRON EMISSION TOMOGRAPHY (1993)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A CONVENIENT METHOD FOR REGIONAL MONOAMINE OXIDASE-A DETERMINATION BY [C-14] CLORGYLINE AUTORADIOGRAPHY (1992)
- International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )