Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- (2009)
- NeuroImage
- (2009)
- Radiological Physics and Technology
- Absolute quantitation of myocardial blood flow with Tl-201 and dynamic SPECT in canine: optimisation and validation of kinetic modellingSeparation of input function for rapid measurement of quantitative CMRO2 and CBF in a single PET scan with a dual tracer administration method2008
- European Journal of Nuclear Medicine and Molecular ImagingPhysics in Medicine and BiologyPhysics in Medicine and Biology
- Acceleration of Monte Carlo-based scatter compensation for cardiac SPECTComparison of Gd-DTPA-induced signal enhancements in rat brain c6 glioma among different pulse sequences in 3-tesla magnetic resonance imagingComparison of multi-ray and point-spread function based resolution recovery methods in pinhole SPECT reconstruction2008
- (2008)
- Acta RadiologicaNuclear Medicine Communications
- Heart and brain circulation and CO2 in healthy menEstimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable O-15-O-22008
- Acta PhysiologicaJournal of Cerebral Blood Flow and Metabolism
- Optimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rateGene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction2008
- Annals of Nuclear MedicineHypertension
- Three-dimensional SPECT reconstruction with transmission-dependent scatter correctionQuantitative mapping of basal and vasareactive cerebral blood flow using split-dose I-123-iodoamphetamine and single photon emission computed tomography2008
- Annals of Nuclear MedicineNeuroImage
- 3D-OSEM reconstruction from truncated data in pinhole SPECTSystem design and development of a pinhole SPECT system for quantitative functional imaging of small animals2007
- IEEE conference record - Nuclear Science Symposium & Medical Imaging ConferenceAnnals of Nuclear Medicine
- Accelerated 3D-OSEM image reconstruction using a Beowulf PC cluster for pinhole SPECT2007
- Annals of Nuclear MedicineBrain
- (2007)
- StrokeAnnals of Nuclear Medicine
- (2007)
- (2006)
- (2006)
- (2006)
- Performance of list mode data acquisition with ECAT EXACT HR and ECAT EXACT HR+ positron emission scanners (2006)
- Annals of Nuclear Medicine
- (2006)
- (2006)
- The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia (2006)
- Use of a compact pixellated gamma camera for small animal pinhole SPECT imaging (2006)



