Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi ORCID identifier: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Reduction in camera-specific variability in [I-123]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls (2016)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Refereed original research article in a scientific journal) - Substantial Reduction of Parenchymal Cerebral Blood Flow in Mice with Bilateral Common Carotid Artery Stenosis (2016)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - A Novel Mouse Model of Subcortical Infarcts with Dementia (2015)
- Journal of Neuroscience
(A1 Refereed original research article in a scientific journal) - Asymmetrical intersection between the middle cerebral artery and rhinal vein suggests asymmetrical gustatory cortex location in rodent hemispheres (2015)
- Neuroscience Letters
(A1 Refereed original research article in a scientific journal) - Combined PET/MRI: Multi-modality Multi-parametric Imaging Is Here (2015)
- Molecular Imaging and Biology
(A1 Refereed original research article in a scientific journal) - Delayed atrophy in posterior cingulate cortex and apathy after stroke (2015)
- International Journal of Geriatric Psychiatry
(A1 Refereed original research article in a scientific journal) - Intraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia ischemia (2015)
- Brain and Development
(A1 Refereed original research article in a scientific journal) - Low amyloid-beta deposition correlates with high education in cognitively normal older adults: a pilot study (2015)
- International Journal of Geriatric Psychiatry
(A1 Refereed original research article in a scientific journal) - Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment (2015)
- Neurobiology of Aging
(A1 Refereed original research article in a scientific journal) - Adequacy of a compartment model for CMRO2 quantitation using O-15-labeled oxygen and PET: a clearance measurement of O-15-radioactivity following intracarotid bolus injection of O-15-labeled oxyhemoglobin on Macaca fascicularis (2014)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal)



