Hidehiro Iida
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ
Turku PET Center hidehiro.iida@utu.fi PET Keskus (14) ORCID identifier: https://orcid.org/0000-0002-7914-3068 |
Instrumentation and modeling in PET, SPECT and medical imaging
Dr.
Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.
Dr.
Hidehiro Iida’s primary interest is the non-invasive imaging of
bio-physiological functions and molecular processes using PET, SPECT and MRI modalities.
He has been working on instrumentation and kinetic modeling-based
methodologies. and contributed to develop several methods to quantitatively
assess tissue perfusion, oxidative metabolism and other functions, in brain,
heart and other organs. Some of those techniques have been utilized in a number
of clinical researches as a gold standard, and also in clinical practice in
patients with cerebral and cardiovascular diseases.
Interest areas in teaching are as follows:
1. PET, SPECT and MR instrumentation
2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem
3. To learn pathophysiology from PET, SPECT and MR images.
- Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion (2024)
- Journal of Stroke
(Refereed journal article or data article (A1)) - Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes (2023)
- Metabolism
(Refereed journal article or data article (A1)) - Neuronal Loss in the Bilateral Medial Frontal Lobe Revealed by 123I-iomazenil Single-photon Emission Computed Tomography in Patients with Moyamoya Disease: The First Report from Cognitive Dysfunction Survey of Japanese Patients with Moyamoya Disease (COSMO-Japan Study) (2023)
- Neurologia Medico-Chirurgica
(Refereed journal article or data article (A1)) - Quantitative Perfusion Imaging with Total-Body PET (2023)
- Journal of Nuclear Medicine
(Refereed review article in scientific journal (A2)) - Renal Cortical Glucose Uptake Is Decreased in Insulin Resistance and Correlates Inversely With Serum Free-fatty Acids (2023)
- Journal of Clinical Endocrinology and Metabolism
(Refereed journal article or data article (A1)) - Small animal PET with spontaneous inhalation of 15O-labelled oxygen gases: Longitudinal assessment of cerebral oxygen metabolism in a rat model of neonatal hypoxic-ischaemic encephalopathy (2023)
- Journal of Cerebral Blood Flow and Metabolism
(Refereed journal article or data article (A1)) - Assessment of a digital and an analog PET/CT system for accurate myocardial perfusion imaging with a flow phantom (2022)
- Journal of Nuclear Cardiology
(Refereed journal article or data article (A1)) - Brown adipose tissue fat-fraction is associated with skeletal muscle adiposity (2022)
- European Journal of Applied Physiology
(Refereed journal article or data article (A1)) - Correction to: Brown adipose tissue fat‑fraction is associated with skeletal muscle adiposity (European Journal of Applied Physiology, (2022), 122, 1, (81-90), 10.1007/s00421-021-04816-z) (2022)
- European Journal of Applied Physiology
(Other (O2)) - Evaluation of [F-18]F-DPA PET for Detecting Microglial Activation in the Spinal Cord of a Rat Model of Neuropathic Pain (2022)
- Molecular Imaging and Biology
(Refereed journal article or data article (A1)) - Evaluation of renal glucose uptake with [F-18]FDG-PET: methodological advancements and clinical outcomes (2022)
- Diabetologia
(Other (O2)) - Accuracy of Non-invasive Arterial Input Functions and Error in Quantitative Images in the Cerebellar Reference Method (2021)
- Kaku igaku. The Japanese journal of nuclear medicine
(Refereed journal article or data article (A1)) - A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model (2021)
- Journal of Nuclear Medicine
(Refereed journal article or data article (A1)) - A non-invasive reference-based method for imaging the cerebral metabolic rate of oxygen by PET/MR: theory and error analysis (2021)
- Physics in Medicine and Biology
(Refereed journal article or data article (A1)) - Consensus recommendations on the use of 18F-FDG PET/CT in lung disease (2020)
- Journal of Nuclear Medicine
(Refereed journal article or data article (A1)) - Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy (2020)
- Journal of Cerebral Blood Flow and Metabolism
(Refereed journal article or data article (A1)) - Magnetic Resonance-Based Attenuation Correction and Scatter Correction in Neurological Positron Emission Tomography/Magnetic Resonance Imaging—Current Status With Emerging Applications (2020)
- Frontiers in Physics
(Refereed review article in scientific journal (A2)) - Quantification Analysis of Behavioral Changes after Sciatic Nerve Ligation in Rats (2020)
- Asia-pacific signal and information processing association annual summit and conference
(Refereed article in conference proceedings (A4)) - Amyloid β deposition in subcortical stroke patients and effects of educational achievement: A pilot study (2019)
- International Journal of Geriatric Psychiatry
(Refereed journal article or data article (A1)) - Detection of brain amyloid‐β deposits due to the repetitive head trauma in a former karate player (2019)
- Psychogeriatrics
(Article or data-article in scientific journal (B1))