MD, PhD, Professor Emeritus Mika Scheinin - UTU Research Portal

Mika Scheinin
MD, PhD, Professor Emeritus

Institute of Biomedicine (Faculty of Medicine)

mschein@utu.fi

: https://orcid.org/0000-0001-7579-9126

Bioanalytics; Clinical Pharmacology; Drug Development; Positron Emission Tomography; Research Ethics

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Gene expression profiles and signaling mechanisms in α2B-adrenoceptor-evoked proliferation of vascular smooth muscle cells (2017)
- BMC Systems Biology
Anna Huhtinen, Vesa Hongisto, Asta Laiho, Eliisa Löyttyniemi, Dirk Pijnenburg, Mika Scheinin
Kliinisten lääketutkimusten eettinen arviointi uudistuu (2017)
- Duodecim
Scheinin M
Plasma concentration and cardiovascular effects of intramuscular medetomidine combined with three doses of the peripheral alpha2-antagonist MK-467 in dogs (2017)
- Veterinary Anaesthesia and Analgesia
Restitutti F., Kaartinen M., Raekallio M., Wejberg O., Mikkola E., del Castillo J., Scheinin M., Vainio O.
Safety, Tolerability, and Antihypertensive Effect of SER100, an Opiate Receptor-Like 1 (ORL-1) Partial Agonist, in Patients With Isolated Systolic Hypertension (2017)
- Clinical Pharmacology in Drug Development
Kantola I, Scheinin M, Gulbrandsen T, Meland N, Smerud KT
The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure (2017)
- Nutrition Journal
Saarenhovi M, Salo P, Scheinin M, Lehto J, Lovro Z, Tiihonen K, Lehtinen MJ, Junnila J, Hasselwander O, Tarpila A, Raitakari OT
The role of active transport in the transcellular movement of the peripheral α2-adrenoceptor antagonist, MK-467: An in vitro pilot study (2017)
- Canadian Journal of Veterinary Research
Bennett R., Palviainen M., Peltoniemi M., Vuorilehto L., Scheinin M., Raekallio M., Vainio O.
Tolerability of ORM-12741 and effects on episodic memory in patients with Alzheimer's disease (2017)
- Alzheimer's & dementia: diagnosis, assessment & disease monitoring
Hakulinen P., Cummings J., Hänninen J., Hallikainen M., Riordan H., Murphy M., Soininen H., Scheinin M., Rouru J., Rinne J., Wesnes K.
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin (2016)
- Bioorganic and Medicinal Chemistry
Jelica Vucicevic, Tatjana Srdic-Rajic, Marco Pieroni, Jonne M. M. Laurila, Vladimir Perovic, Sabrina Tassini, Elisa Azzali, Gabriele Costantino, Sanja Glisic, Danica Agbaba, Mika Scheinin, Katarina Nikolic, Marco Radi, Nevena Veljkovic
Clinical effects and pharmacokinetic variables of romifidine and the peripheral alfa2-adrenoceptor antagonist MK-467 in horses (2016)
- Veterinary Anaesthesia and Analgesia
De Vries Annemarie, Pakkanen Soile AE, Raekallio Marja R, Ekiri Abel, Scheinin Mika, Taylor Polly M, Vainio Outi M
Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the α2C-adrenoceptor PET ligand [11C]ORM-13070 (2016)
- Synapse
Lehto J, Scheinin A, Johansson J, Marjamäki P, Arponen E, Scheinin H, Scheinin M
Differential internalization rates and postendocytic sorting of the norepinephrine and dopamine transporters are controlled by structural elements in the N-termini (2016)
- Journal of Biological Chemistry
Vuorenpää A, Jørgensen TN, Newman AH, Madsen KL, Scheinin M, Gether U
Effects of MK-467 on the antinociceptive and sedative actions and pharmacokinetics of medetomidine in dogs (2016)
- Journal of Veterinary Pharmacology and Therapeutics
Bennett RC, Salla KM, Raekallio MR, Hanninen L, Rinne VM, Scheinin M, Vainio OM
Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Contolled Trial (2016)
- EBioMedicine
Stenman Lotta K., Lehtinen Markus J., Meleand Nils, Christensen jeffrey E.,Yeung Nicola, Saarinen Markku T., Courteny Michael, Burcelin Rémy, Lähdeaho Marja-Leena, Lindros Jüri, Apter dan, Scheinin Mika, Smerus Hilde Kloster, Rissanen Aila, Lahtinen Sampo
Report on the Ethical Review Process for Clinical Trials in the Nordic Countries - the Challenges and Opportunities of the New Clinical Trials Regulation (2016) Scheinin Mika, Tenovuo Juliana; The Nordic Trial Alliance Working Group on Ethics
Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers: A Nonblinded, Randomized Crossover Study (2016)
- Anesthesiology
Lodenius åse, Ebberyd Anette, Hårdemark Cedrborg Anna, Hagel Eva, Mkrtchian Souren, Christensson Eva, Ullman Johan, Schenin Mika, Eriksson Lars I, Fagerlund Malin Johan
Transfer of SAR information from hypotensive indazole to indole derivatives acting at alpha-adrenergic receptors: In vitro and in vivo studies (2016)
- European Journal of Medicinal Chemistry
Saczewski J, Hudson A, Scheinin M, Wasilewska A, Saczewski F, Rybczynska A, Ferdousi M, Laurila JM, Boblewski K, Lehmann A, Watts H, Ma DQ
Amphetamine Decreases α2C-Adrenoceptor Binding of [11C]ORM-13070 - A PET Study in the Primate Brain (2015)
- International Journal of Neuropsychopharmacology
Finnema SJ, Hughes ZA, Haaparanta-Solin M, Stepanov V, Nakao R, Varnäs K, Varrone A, Arponen E, Marjamäki P, Pohjanoksa K, Vuorilehto L, Babalola PA, Solin O, Grimwood S, Sallinen J, Farde L, Scheinin M, Halldin C
Application of cross-species PET imaging to assess neurotransmitter release in brain (2015)
- Psychopharmacology
Finnema SJ, Scheinin M, Shahid M, Lehto J, Borroni E, Bang-Andersen B, Sallinen J, Wong E, Farde L, Halldin C, Grimwood S
Comparison of simultaneous measurement of mouse locomotor activity by radiotelemetry and photobeam methods (2015)
- Journal of Pharmacological and Toxicological Methods
Tomi Streng, Tero Klemola, Sanna Bastman, Jaakko Nevalainen, Mika Scheinin
Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane (2015)
- Veterinary Anaesthesia and Analgesia
Pakkanen SA, Raekallio MR, Mykkänen AK, Salla KM, de Vries A, Vuorilehto L, Scheinin M, Vainio OM