MD, PhD, Professor Emeritus Mika Scheinin - UTU Research Portal

Mika Scheinin
MD, PhD, Professor Emeritus

Institute of Biomedicine (Faculty of Medicine)

mschein@utu.fi

: https://orcid.org/0000-0001-7579-9126

Bioanalytics; Clinical Pharmacology; Drug Development; Positron Emission Tomography; Research Ethics

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Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol (2015)
- European Journal of Clinical Pharmacology
Saarikoski T, Saari TI, Hagelberg NM, Backman JT, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K
Imaging of a2C-adrenoceptors in the living brain: a method to monitor noradrenaline release? (2015)
- SpringerPlus
Scheinin M, Lehto J, Johansson J, Luoto P, Arponen E, Vuorilehto L, Scheinin H, Rouru J
Kliiniset tutkimukset muistisairailla (2015) Kliinisen tutkimuksen etiikka - Opas tutkijoille ja eettisille toimikunnille Scheinin M, Rinne JO, Keränen T
Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects (2015)
- European Journal of Clinical Pharmacology
Yoo H, Iirola T, Vilo S, Manner T, Aantaa R, Lahtinen M, Scheinin M, Olkkola KT, Jusko WJ
Potentiation of Glibenclamide Hypoglycaemia in Mice by MK-467, a Peripherally Acting Alpha2-Adrenoceptor Antagonist (2015)
- Basic and Clinical Pharmacology and Toxicology
Ruohonen ST, Ranta-Panula V, Bastman S, Chrusciel P, Scheinin M, Streng T
Sensitivity of [C-11]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects (2015)
- Psychopharmacology
Lehto J, Johansson J, Vuorilehto L, Luoto P, Arponen E, Scheinin H, Rouru J, Scheinin M
Test-retest reliability of (11)C-ORM-13070 in PET imaging of α2C-adrenoceptors in vivo in the human brain (2015)
- European Journal of Nuclear Medicine and Molecular Imaging
Jussi Lehto, Jere R. Virta, Vesa Oikonen, Anne Roivainen, Pauliina Luoto, Eveliina Arponen, Semi Helin, Johanna Hietamäki, Aila Holopainen, Marita Kailajärvi, Juha M. Peltonen, Juha Rouru, Jukka Sallinen, Kirsi Virtanen, Iina Volanen, Mika Scheinin, Juha O. Rinne
Transparency and Registration in Clinical Research in the Nordic Countries – Nordic Trial Alliance report, NordForsk (2015) Skoog M, Saarimäki JM, Gluud C, Scheinin M, Erlendsson K, Aamdal S, Cabral Iversen V, Mørkved S, Englund M, Jacobsson E-C
Tutkimuksen eettinen ennakkoarviointi (2015) Kliinisen tutkimuksen etiikka - Opas tutkijoille ja eettisille toimikunnille Varis T, Scheinin M, Tuominen JP, Pasternack A
Validation of [11C]ORM-13070 as a PET tracer for alpha2c-adrenoceptors in the human brain (2015)
- Synapse
Jussi Lehto, Mika M. Hirvonen, Jarkko Johansson, Jukka Kemppainen, Pauliina Luoto, Tarja Naukkarinen, Vesa Oikonen, Eveliina Arponen, Juha Rouru, Jukka Sallinen, Harry Scheinin, Lauri Vuorilehto, Sjoerd J. Finnema, Christer Halldin, Juha O. Rinne, Mika Scheinin
¹¹C-ORM-13070, a novel PET ligand for brain α₂C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men. (2014)
- European Journal of Nuclear Medicine and Molecular Imaging
Luoto P, Suilamo S, Oikonen V, Arponen E, Helin S, Herttuainen J, Hietamäki J, Holopainen A, Kailajärvi M, Peltonen JM, Rouru J, Sallinen J, Scheinin M, Virta J, Virtanen K, Volanen I, Roivainen A, Rinne JO
A PET Tracer for Brain α2C Adrenoceptors, 11C-ORM-13070: Radiosynthesis and Preclinical Evaluation in Rats and Knockout Mice (2014)
- Journal of Nuclear Medicine
Arponen E, Helin S, Marjamäki P, Grönroos T, Holm P, Löyttyniemi E, Någren K, Scheinin M, Haaparanta-Solin M, Sallinen J, Solin O
Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities. (2014)
- European Journal of Medicinal Chemistry
Wasilewska A, Sączewski F, Hudson AL, Ferdousi M, Scheinin M, Laurila JM, Rybczyńska A, Boblewski K, Lehmann A
In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol (2014)
- EJNMMI Research
Anniina Snellman, Johanna Rokka, Francisco R López-Picón, Olli Eskola, Mario Salmona, Gianluigi Forloni, Mika Scheinin, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin
Quantitative determination of α2B-adrenoceptor-evoked myosin light chain phosphorylation in vascular smooth muscle cells (2014)
- Journal of Pharmacological and Toxicological Methods
Björk Susann, Huhtinen Anna, Vuorenpää Anne, Scheinin Mika
Reply to "Letter to the editor: 'Deconstructing the dogma of sympathetic restraint and its role in the cardiovascular response to exercise'" (2014)
- AJP - Regulatory, Integrative and Comparative Physiology
Heinonen I, Wendelin-Saarenhovi M, Kaskinoro K, Knuuti J, Scheinin M, Kalliokoski KK
Sublingual administration of detomidine to calves prior to disbudding: a comparison with the intravenous route (2014)
- Veterinary Anaesthesia and Analgesia
Hokkanen AH, Raekallio MR, Salla K, Hänninen L, Viitasaari E, Norring M, Raussi S, Rinne VM, Scheinin M, Vainio OM
Adrenoseptoriagonistit (sympatomimeetit) (2013) Farmakologia ja toksikologia Scheinin Mika
A polymorphism in the protein kinase C gene PRKCB is associated with alpha(2)-adrenoceptor-mediated vasoconstriction (2013)
- Pharmacogenetics and Genomics
Posti JP, Salo P, Ruohonen S, Valve L, Muszkat M, Sofowora GG, Kurnik D, Stein CM, Perola M, Scheinin M, Snapir A
Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene (2013)
- Biopharmaceutics and Drug Disposition
Lehtinen T, Tolonen A, Turpeinen M, Uusitalo J, Vuorinen J, Lammintausta R, Pelkonen O, Scheinin M