Johanna Schleutker
PhD, Professor of Medical Genetics
Asiantuntijuusalueet
Cancer genetics; hereditary cancer; genomics; human genetics
Biografia
Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.
Tutkimus
The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.
Opetus
Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.
Julkaisut
- Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study (2026) Vassy, Jason L.; Dornisch, Anna M.; Karunamuni, Roshan; Gatzen, Michael; Kachulis, Christopher J.; Lennon, Niall J.; Brunette, Charles A.; Danowski, Morgan E.; Hauger, Richard L.; Garraway, Isla P.; Kibel, Adam S.; Lee, Kyung M.; Lynch, Julie A.; Maxwell, Kara N.; Ratner, Dmitry; Rose, Brent S.; Teerlink, Craig C.; Xu, George J.; Hofherr, Sean E.; Lafferty, Katherine A.; Larkin, Katie; Malolepsza, Edyta; Patterson, Candace J.; Toledo, Diana M.; Donovan, Jenny L.; Hamdy, Freddie C.; Martin, Richard M.; Neal, David E.; Turner, Emma L.; Andreassen, Ole A.; Dale, Anders M.; Mills, Ian G.; Abraham, Aswin; Batra, Jyotsna; Clements, Judith; Cussenot, Olivier; Cybulski, Cezary; Eeles, Rosalind A.; Fowke, Jay H.; Grindedal, Eli Marie; Grönberg, Henrik; Hamilton, Robert J.; Lim, Jasmine; Lu, Yong-Jie; MacInnis, Robert J.; Maier, Christiane; Mucci, Lorelei A.; Multigner, Luc; Neuhausen, Susan L.; Nielsen, Sune F.; Parent, Marie-Élise; Park, Jong Y.; Petrovics, Gyorgy; Plym, Anna; Razack, Azad; Rosenstein, Barry S.; Schleutker, Johanna; Dalsgaard Sørensen, Karina; Townsend, Paul A.; Travis, Ruth C.; Vega, Ana; West, Catharine M. L.; Wiklund, Fredrik; Zheng, Wei; Profile Steering Committee; IMPACT Study Steering Committee and Collaborators; PRACTICAL Consortium; VA Million Veteran Program; Seibert, Tyler M.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism (2025)
- Cell communication and signaling
Löf, Christoffer; Sultana, Nasrin; Goel, Neha; Heron, Samuel; Wahlström, Gudrun; House, Andrew; Holopainen, Minna; Käkelä, Reijo; Schleutker, Johanna
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- SNP genotypes in CYP2C9 and VKORC1 genes do not affect prostate cancer or cancer mortality among warfarin users in Finnish prostate cancer patients (2025) Murtola, Teemu J.; Skantsi, Kaisa M.; Siltari, Aino; Talala, Kirsi; Taari, Kimmo; Tammela, Teuvo L.J.; Schleutker, Johanna; Auvinen, Anssi; Sipeky, Csilla
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Spatial profiling of ANO7 in prostate tissue: links to AR-signalling-associated lipid metabolism and inflammation (2025) Metsälä, Olli; Wahlström, Gudrun; Goel, Neha; Miihkinen, Mitro; Taimen, Pekka; Schleutker, Johanna
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer (2024) Srinivasan, Srilakshmi; Kryza, Thomas; Bock, Nathalie; Tse, Brian W. C.; Sokolowski, Kamil A.; Janaththani, Panchadsaram; Fernando, Achala; Moya, Leire; Stephens, Carson; Dong, Ying; Röhl, Joan; Alinezhad, Saeid; Vela, Ian; Perry-Keene, Joanna L.; Buzacott, Katie; Nica, Robert; Gago-Dominguez, Manuela; Schleutker, Johanna; Maier, Christiane; Muir, Kenneth; Tangen, Catherine M.; Gronberg, Henrik; Pashayan, Nora; Albanes, Demetrius; Wolk, Alicja; Stanford, Janet L.; Berndt, Sonja I.; Mucci, Lorelei A.; Koutros, Stella; Cussenot, Olivier; Sorensen, Karina Dalsgaard; Grindedal, Eli Marie; Travis, Ruth C.; Haiman, Christopher A.; MacInnis, Robert J.; Vega, Ana; Wiklund, Fredrik; Neal, David E.; Kogevinas, Manolis; Penney, Kathryn L.; Nordestgaard, Børge G.; Brenner, Hermann; John, Esther M.; Gamulin, Marija; Claessens, Frank; Melander, Olle; Dahlin, Anders; Stattin, Pär; Hallmans, Göran; Häggström, Christel; Johansson, Robert; Thysell, Elin; Rönn, Ann-Charlotte; Li, Weiqiang; Brown, Nigel; Dimeski, Goce; Shepherd, Benjamin; Dadaev, Tokhir; Brook, Mark N.; Spurdle, Amanda B.; Stenman, Ulf-Håkan; Koistinen, Hannu; Kote-Jarai, Zsofia; Klein, Robert J.; Lilja, Hans; Ecker, Rupert C.; Eeles, Rosalind; Clements, Judith; Batra, Jyotsna; The IMPACT Study; The PROFILE Study Steering Committee; The Practical Consortium; The Australian Prostate Cancer BioResource
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Cluster effect for SNP-SNP interaction pairs for predicting complex traits (2024) Li,n Hui-Yi; Mazumder, Harun; Sarkar, Indrani; Huang, Po-Yu; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth R.; Schleutker, Johanna; Pashayan, Nora; Batra, Joytsna; Neal, David E.; Nielsen, Sune F.; Nordestgaard, Börge G.; Grönberg, Henrik; Wiklund, Fredrik; MacInnis, Robert J.; Haiman, Christopher A.; Travis, Ruth C.; Stanford, Janet L.; Kibel, Adam S.; Cybulski, Cezary; Khaw, Kay-Tee; Maier, Christiane; Thibodeau, Stephen N.; Teixeira, Manuel R.; Cannon-Albright, Lisa; Brenner, Hermann; Kaneva, Radka; Pandha, Hardev; The PRACTICAL consortium; Park, Jong Y.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Kuura—An automated workflow for analyzing WES and WGS data (2024) Jambulingam, Dhanaprakash; Rathinakannan, Venkat Subramaniam; Heron, Samuel; Schleutker, Johanna; Fey, Vidal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Rare Germline Variants in DNA Repair Genes Detected in BRCA-Negative Finnish Patients with Early-Onset Breast Cancer (2024) Kurkilahti, Viivi; Rathinakannan, Venkat Subramaniam; Nynäs, Erja; Goel, Neha; Aittomäki, Kristiina; Nevanlinna, Heli; Fey, Vidal; Kankuri-Tammilehto, Minna; Schleutker, Johanna
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants (2023) Wang A., Shen J., Rodriguez A.A., Saunders E.J., Chen F., Janivara R., Darst B.F., Sheng X., Xu Y., Chou A.J., Benlloch S., Dadaev T., Brook M.N., Plym A., Sahimi A., Hoffman T.J., Takahashi A., Matsuda K., Momozawa Y., Fujita M., Laisk T., Figuerêdo J., Muir K., Ito S., Liu X., Yamanashi Y., Furukawa Y., Morisaki T., Murakami Y., Muto K., Nagai A., Obara W., Yamaji K., Takahashi K., Asai S., Takahashi Y., Suzuki T., Sinozaki N., Yamaguchi H., Minami S., Murayama S., Yoshimori K., Nagayama S., Obata D., Higashiyama M., Masumoto A., Koretsune Y., Uchio Y., Kubo M., Kamatani Y., Lophatananon A., Wan P., Andrews C., Lori A., Choudhury P.P., Schleutker J., Tammela T.L.J., Sipeky C., Auvinen A., Giles G.G., Southey M.C., MacInnis R.J., Cybulski C., Wokolorczyk D., Lubinski J., Rentsch C.T., Cho K., Mcmahon B.H., Neal D.E., Donovan J.L., Hamdy F.C., Martin R.M., Nordestgaard B.G., Nielsen S.F., Weischer M., Bojesen S.E., Røder A., Stroomberg H.V., Batra J., Chambers S., Horvath L., Clements J.A., Tilly W., Risbridger G.P., Gronberg H., Aly M., Szulkin R., Eklund M., Nordstrom T., Pashayan N., Dunning A.M., Ghoussaini M., Travis R.C., Key T.J., Riboli E., Park J.Y., Sellers T.A., Lin H.Y., Albanes D., Weinstein S., Cook M.B., Mucci L.A., Giovannucci E., Lindstrom S., Kraft P., Hunter D.J., Penney K.L., Turman C., Tangen C.M., Goodman P.J., Thompson I.M., Hamilton R.J., Fleshner N.E., Finelli A., Parent M.É., Stanford J.L., Ostrander E.A., Koutros S., Beane Freeman L.E., Stampfer M., Wolk A., Håkansson N., Andriole G.L., Hoover R.N., Machiela M.J., Sørensen K.D., Borre M., Blot W.J., Zheng W., Yeboah E.D., Mensah J.E., Lu Y.J., Zhang H.W., Feng N., Mao X., Wu Y., Zhao S.C., Sun Z., Thibodeau S.N., McDonnell S.K., Schaid D.J., West C.M.L., Barnett G., Maier C., Schnoeller T., Luedeke M., Kibel A.S., Drake B.F., Cussenot O., Cancel-Tassin G., Menegaux F., Truong T., Koudou Y.A., John E.M., Grindedal E.M., Maehle L., Khaw K.T., Ingles S.A., Stern M.C., Vega A., Gómez-Caamaño A., Fachal L., Rosenstein B.S., Kerns S.L., Ostrer H., Teixeira M.R., Paulo P., Brandão A., Watya S., Lubwama A., Bensen J.T., Butler E.N., Mohler J.L., Taylor J.A., Kogevinas M., Dierssen-Sotos T., Castaño-Vinyals G., Cannon-Albright L., Teerlink C.C., Huff C.D., Pilie P., Yu Y., Bohlender R.J., Gu J., Strom S.S., Multigner L., Blanchet P., Brureau L., Kaneva R., Slavov C., Mitev V., Leach R.J., Brenner H., Chen X., Holleczek B., Schöttker B., Klein E.A., Hsing A.W., Kittles R.A., Murphy A.B., Logothetis C.J., Kim J., Neuhausen S.L., Steele L., Ding Y.C., Isaacs W.B., Nemesure B., Hennis A.J.M., Carpten J., Pandha H., Michael A., De Ruyck K., De Meerleer G., Ost P., Xu J., Razack A., Lim J., Teo S.H., Newcomb L.F., Lin D.W., Fowke J.H., Neslund-Dudas C.M., Rybicki B.A., Gamulin M., Lessel D., Kulis T., Usmani N., Abraham A., Singhal S., Parliament M., Claessens F., Joniau S., Van den Broeck T., Gago-Dominguez M., Castelao J.E., Martinez M.E., Larkin S., Townsend P.A., Aukim-Hastie C., Bush W.S., Aldrich M.C., Crawford D.C., Srivastava S., Cullen J., Petrovics G., Casey G., Wang Y., Tettey Y., Lachance J., Tang W., Biritwum R.B., Adjei A.A., Tay E., Truelove A., Niwa S., Yamoah K., Govindasami K., Chokkalingam A.P., Keaton J.M., Hellwege J.N., Clark P.E., Jalloh M., Gueye S.M., Niang L., Ogunbiyi O., Shittu O., Amodu O., Adebiyi A.O., Aisuodionoe-Shadrach O.I., Ajibola H.O., Jamda M.A., Oluwole O.P., Nwegbu M., Adusei B., Mante S., Darkwa-Abrahams A., Diop H., Gundell S.M., Roobol M.J., Jenster G., van Schaik R.H.N., Hu J.J., Sanderson M., Kachuri L., Varma R., McKean-Cowdin R., Torres M., Preuss M.H., Loos R.J.F., Zawistowski M., Zöllner S., Lu Z., Van Den Eeden S.K., Easton D.F., Ambs S., Edwards T.L., Mägi R., Rebbeck T.R., Fritsche L., Chanock S.J., Berndt S.I., Wiklund F., Nakagawa H., Witte J.S., Gaziano J.M., Justice A.C., Mancuso N., Terao C., Eeles R.A., Kote-Jarai Z., Madduri R.K., Conti D.V., Haiman C.A.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry (2023)
- American Journal of Human Genetics
Burcu F. Darst, Jiayi Shen, Ravi K. Madduri, Alexis A. Rodriguez, Yukai Xiao, Xin Sheng, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Thomas J. Hoffmann, Kenneth Muir, Peggy Wan, Le Marchand Loic, Lynne Wilkens, Ying Wang, Johanna Schleutker, Robert J. MacInnis, Cezary Cybulski, David E. Neal, Børge G. Nordestgaard, Sune F. Nielsen, Jyotsna Batra, Judith A. Clements, Henrik Grönberg, Nora Pashayan, Ruth C. Travis, Jong Y. Park, Demetrius Albanes, Stephanie Weinstein, Lorelei A. Mucci, David J. Hunter, Kathryn L. Penney, Catherine M. Tangen, Robert J. Hamilton, Marie-Élise Parent, Janet L. Stanford, Stella Koutros, Alicja Wolk, Karina D. Sørensen, William J. Blot, Edward D. Yeboah, James E. Mensah, Yong-Jie Lu, Daniel J. Schaid, Stephen N. Thibodeau, Catharine M. West, Christiane Maier, Adam S. Kibel, Géraldine Cancel-Tassin, Florence Menegaux, Esther M. John, Grindedal Eli Marie, Kay-Tee Khaw, Sue A. Ingles, Ana Vega, Barry S. Rosenstein, Manuel R. Teixeira, Manolis Kogevinas, Lisa Cannon-Albright, Chad Huff, Luc Multigner, Radka Kaneva, Robin J. Leach, Hermann Brenner, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Susan L. Neuhausen, William B. Isaacs, Barbara Nemesure, Anselm J. Hennis, John Carpten, Hardev Pandha, De Ruyck Kim, Jianfeng Xu, Azad Razack, Soo-Hwang Teo, Lisa F. Newcomb, Jay H. Fowke, Christine Neslund-Dudas, Benjamin A. Rybicki, Marija Gamulin, Nawaid Usmani, Frank Claessens, Manuela Gago-Dominguez, Castelao Jose Esteban, Paul A. Townsend, Dana C. Crawford, Gyorgy Petrovics, Graham Casey, Monique J. Roobol, Jennifer F. Hu, Sonja I. Berndt, Van Den Eeden Stephen K., Easton Douglas F., Chanock Stephen J., Cook Michael B., Wiklund Fredrik, Witte John S., Eeles Rosalind A., Kote-Jarai Zsofia, Watya Stephen, Gaziano John M., Justice Amy C., Conti David V., Haiman Christopher A.; Australian Prostate Cancer BioResource; NC-LA PCaP Investigators; Canary PASS Investigators
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