Johanna Lempainen
Clinical lecturer
johanna.lempainen@utu.fi Department of Pediatrics, Institute of Clinical Medicine, University of Turku Unit for Rare Diseases, Turku University Hospital |
Areas of expertise
pediatrics; pathogenesis of type 1 diabetes; pediatric infections; pediatric immunology
pediatrics; pathogenesis of type 1 diabetes; pediatric infections; pediatric immunology
Biography
Docent Johanna Lempainen
graduated from medical school in 2004 (University of Turku) and defended her
PhD theses on pathogenesis of type 1 diabetes in 2009. She received specialist
licence in paediatrics in 2015 and was appointed as a docent of experimental
paediatrics in 2018 (University of Turku). She is currently working as clinical
lecturer at the department of pediatrics at University of Turku and as
specialist at the Unit for Rare Diseases, Turku University Hospital. She
participates in neonatal screening for severe immunodeficiencies and in
laboratory diagnostics of immunodeficiencies. Training for subspecialty in
pediatric infections and immunodeficiencies is ongoing.
Docent Johanna Lempainen
graduated from medical school in 2004 (University of Turku) and defended her
PhD theses on pathogenesis of type 1 diabetes in 2009. She received specialist
licence in paediatrics in 2015 and was appointed as a docent of experimental
paediatrics in 2018 (University of Turku). She is currently working as clinical
lecturer at the department of pediatrics at University of Turku and as
specialist at the Unit for Rare Diseases, Turku University Hospital. She
participates in neonatal screening for severe immunodeficiencies and in
laboratory diagnostics of immunodeficiencies. Training for subspecialty in
pediatric infections and immunodeficiencies is ongoing.
Research
Docent Lempainen’s
thesis in 2009 focused on the pathogenesis of type 1 diabetes. Since then her
research work has further focused on the heterogeneity of type 1 diabetes
pathogenesis. In 2011 she worked as visiting researcher in the
BabyDiab-diabetes study group in Munich,
Germany. Her current research interests comprise the etiology of beta-cell
autoimmunity in respect of immunological, genetic and epigenetic factors and
disturbances in early microbial contacts and are a part of the prospective
Diabetes Prediction and Prevention (DIPP) study. In addition, she participates
in research projects aiming at early detection of bacterial and viral
infections in infants and children in order to avoid unnecessary antibiotic
exposure. Since January 2020 docent Lempainen is the principal investigator of the Immunogenetics laboratory and PI and member of steering committee in the DIPP study at the University of Turku.
Docent Lempainen’s
thesis in 2009 focused on the pathogenesis of type 1 diabetes. Since then her
research work has further focused on the heterogeneity of type 1 diabetes
pathogenesis. In 2011 she worked as visiting researcher in the
BabyDiab-diabetes study group in Munich,
Germany. Her current research interests comprise the etiology of beta-cell
autoimmunity in respect of immunological, genetic and epigenetic factors and
disturbances in early microbial contacts and are a part of the prospective
Diabetes Prediction and Prevention (DIPP) study. In addition, she participates
in research projects aiming at early detection of bacterial and viral
infections in infants and children in order to avoid unnecessary antibiotic
exposure. Since January 2020 docent Lempainen is the principal investigator of the Immunogenetics laboratory and PI and member of steering committee in the DIPP study at the University of Turku.
Teaching
Docent Lempainen works
as clinical lecturer in pediatrics (part-time) since January 2017.
Docent Lempainen works
as clinical lecturer in pediatrics (part-time) since January 2017.
Publications 
3 of 4
- Harvinaissairaudet tulee saada rekistereihin (2021)
- Lääkärilehti
(D1 Article in a professional journal) - Tri-SNP polymorphism in the intron of HLA-DRA1 affects type 1 diabetes susceptibility in the Finnish population (2021)
- Human Immunology
(A1 Refereed original research article in a scientific journal) - HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity (2020)
- Pediatric Diabetes
(A1 Refereed original research article in a scientific journal) - Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies (2020)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Multiplexed High-Throughput Serological Assay for Human Enteroviruses (2020)
- Microorganisms
(A1 Refereed original research article in a scientific journal) - Multiplexed High-Throughput Serological Assay for Human Enteroviruses (correction vol 8, 963, 2020) (2020) Saarinen NVV, Lehtonen J, Veijola R, Lempainen J, Knip M, Hyoty H, Laitinen OH, Hytonen VP
(Other publication) - Prevalence of respiratory viruses and antiviral MxA responses in children with febrile urinary tract infection (2020)
- European Journal of Clinical Microbiology and Infectious Diseases
(A1 Refereed original research article in a scientific journal) - Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood (2019)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk (2019)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes (2019)
- Pediatric Diabetes
(A1 Refereed original research article in a scientific journal) - The heterogeneous pathogenesis of type 1 diabetes mellitus (2019)
- Nature Reviews Endocrinology
(A2 Refereed review article in a scientific journal ) - Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells (2019)
- European Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies (2018)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity (2018)
- Pediatric Diabetes
(A1 Refereed original research article in a scientific journal) - Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection (2017)
- Journal of Infection
(A1 Refereed original research article in a scientific journal) - Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility (2017)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Class II HLA genotype association with FPIR reflects the islet autoantibody status (2016)
- Scandinavian Journal of Immunology
(Other publication) - Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity (2016)
- Pediatric Diabetes
(A1 Refereed original research article in a scientific journal) - HbA(1c) Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk (2015)
- Diabetes
(A1 Refereed original research article in a scientific journal) - Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease (2015)
- Journal of Autoimmunity
(A1 Refereed original research article in a scientific journal)
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