Kumail Motiani
MD, PhD
kumail.k.motiani@utu.fi ORCID identifier: https://orcid.org/orcid.org/0000-0001-7366-0120 |
Areas of expertise
PET, Liver, Intestine, Pancreas, Gut microbiota, Cancer, Exercise
PET, Liver, Intestine, Pancreas, Gut microbiota, Cancer, Exercise
Research
The benefits of exercise in the treatment of diabetes have been advocated since as early as the 5th century. Most of the consensus is because exercise improves insulin sensitivity (mostly through its effects in the muscle). But just as the aetiology of diabetes is multifactorial, the beneficial effects of exercise cannot be attributed just to the changes in the muscle. Other organs (liver, pancreas and intestine) have been shown to also play an important role in the pathogenesis. Although much has been debated about the role of these organs in the pathogenesis of type 2 diabetes little attention has been directed towards how exercise affects these organs.
I am particularly interested in understanding how the exercise-mediated signals affect these organs and how these interactions lead to improvements in the whole body metabolism. My research aims to answer these questions and it will be one of the first where the effects of exercise will be studied so extensively in humans and animals using modern molecular imaging techniques available. Furthermore, by measuring how liver, pancreas and intestine respond to different modes of exercise intensities in healthy and type 2 diabetic patients will provide new details for innovative interventions aimed at preventing diabetes and complications associated with it.
The benefits of exercise in the treatment of diabetes have been advocated since as early as the 5th century. Most of the consensus is because exercise improves insulin sensitivity (mostly through its effects in the muscle). But just as the aetiology of diabetes is multifactorial, the beneficial effects of exercise cannot be attributed just to the changes in the muscle. Other organs (liver, pancreas and intestine) have been shown to also play an important role in the pathogenesis. Although much has been debated about the role of these organs in the pathogenesis of type 2 diabetes little attention has been directed towards how exercise affects these organs.
I am particularly interested in understanding how the exercise-mediated signals affect these organs and how these interactions lead to improvements in the whole body metabolism. My research aims to answer these questions and it will be one of the first where the effects of exercise will be studied so extensively in humans and animals using modern molecular imaging techniques available. Furthermore, by measuring how liver, pancreas and intestine respond to different modes of exercise intensities in healthy and type 2 diabetic patients will provide new details for innovative interventions aimed at preventing diabetes and complications associated with it.
Publications
- Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training (2020)
- Journal of Clinical Endocrinology and Metabolism
(Refereed journal article or data article (A1)) - Exercise training improves adipose tissue metabolism and vasculature regardless of baseline glucose tolerance and sex (2020)
- BMJ open diabetes research and care
(Refereed journal article or data article (A1)) - Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia (2020)
- Medicine and Science in Sports and Exercise
(Refereed journal article or data article (A1)) - Career pathways and professional skills of postgraduate students from a dental research-intensive programme (2019)
- European Journal of Dental Education
(Refereed journal article or data article (A1)) - Comment on ‘Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial’. Reply to Amini P and Moharamzadeh S [letter] (2019)
- Diabetologia
(Article or data-article in scientific journal (B1)) - Effects of short-term exercise training on liver, pancreas and intestinal metabolism (2019) Motiani Kumail Kumar
(Doctoral dissertation (article) (G5)) - Effects of short-term sprint interval and moderate-intensity continuous training on liver fat content, lipoprotein profile, and substrate uptake: a randomized trial (2019)
- Journal of Applied Physiology
(Refereed journal article or data article (A1)) - Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial (2018)
- Diabetologia
(Refereed journal article or data article (A1)) - Increased insulin-stimulated glucose uptake in both leg and arm muscles after sprint interval and moderate intensity training in subjects with Type 2 Diabetes or Prediabetes (2018)
- Scandinavian Journal of Medicine and Science in Sports
(Refereed journal article or data article (A1)) - Short-term interval training alters brain glucose metabolism in subjects with insulin resistance (2018)
- Journal of Cerebral Blood Flow and Metabolism
(Refereed journal article or data article (A1)) - Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men (2017)
- Diabetes, Obesity and Metabolism
(Refereed journal article or data article (A1)) - Effects of short-term exercise training on intestinal metabolism and gut microbiota in subjects with insulin resistance (2017)
- Diabetologia
(Other (O2)) - Exercise Training Reduces Intrathoracic Fat Regardless of Defective Glucose Tolerance (2017)
- Medicine and Science in Sports and Exercise
(Refereed journal article or data article (A1)) - Sprint interval training decreases left-ventricular glucose uptake compared to moderate-intensity continuous training in subjects with type 2 diabetes or prediabetes (2017)
- Scientific Reports
(Refereed journal article or data article (A1)) - Two weeks of exercise training improves bone marrow metabolism (2017)
- Diabetologia
(Other (O2)) - Two weeks of moderate-intensity continuous training, but not high-intensity interval training, increases insulin-stimulated intestinal glucose uptake (2017)
- Journal of Applied Physiology
(Refereed journal article or data article (A1)) - Exercise Training Reduces Epi- and Pericardial Fat Masses in Healthy and Type 2 Diabetic Subjects (2016)
- Diabetes
(Other (O2)) - High-intensity interval training changes insulin stimulated cerebral glucose uptake of in subjects with impaired glucose tolerance (2016)
- Diabetologia
(Other (O2)) - Left ventricular vascular and metabolic adaptations to high-intensity interval and moderate intensity continuous training: a randomized trial in healthy middle-aged men (2016)
- Journal of Physiology
(Refereed journal article or data article (A1)) - Moderate intensity exercise training rapidly increases insulin stimulated intestinal glucose uptake in sedentary individuals (2015)
- Diabetologia
(Other (O2))