Olli Tenovuo
MD, PhD, Prof. of Neurotraumatology
Areas of expertise
traumatic brain injury; rehabilitation; biomarkers; imaging
Research community or research topic
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury
Biography
I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.
Research
The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.
Teaching
Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.
Publications
- Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research (2017) Maas AIR, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, Bragge P, Brazinova A, Burki A, Chesnut RM, Citerio G, Coburn M, Cooper DJ, Crowder AT, Czeiter E, Czosnyka M, Diaz-Arrastia R, Dreier JP, Duhaime AC, Ercole A, van Essen TA, Feigin VL, Gao GY, Giacino J, Gonzalez-Lara LE, Gruen RL, Gupta D, Hartings JA, Hill S, Jiang JY, Ketharanathan N, Kompanje EJO, Lanyon L, Laureys S, Lecky F, Levin H, Lingsma HF, Maegele M, Majdan M, Manley G, Marsteller J, Mascia L, McFadyen C, Mondello S, Newcombe V, Palotie A, Parizel PM, Peul W, Piercy J, Polinder S, Puybasset L, Rasmussen TE, Rossaint R, Smielewski P, Soderberg J, Stanworth SJ, Stein MB, von Steinbuchel N, Stewart W, Steyerberg EW, Stocchetti N, Synnot A, Ao BT, Tenovuo O, Theadom A, Tibboel D, Videtta W, Wang KKW, Williams WH, Wilson L, Yaffe K; for the InTBIR Participants and Investigators
(A2 Refereed review article in a scientific journal )
- Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: A survey in 66 neurotrauma centers participating in the CENTER-TBI study (2017) Cnossen M., Huijben J., van der Jagt M., Volovici V., van Essen T., Polinder S., Nelson D., Ercole A., Stocchetti N., Citerio G., Peul W., Maas A., Menon D., Steyerberg E., Lingsma H., Adams H., Alessandro M., Allanson J., Amrein K., Andaluz N., Andelic N., Andrea N., Andreassen L., Anke A., Antoni A., Ardon H., Audibert G., Auslands K., Azouvi P., Baciu C., Bacon A., Badenes R., Baglin T., Bartels R., Barzó P., Bauerfeind U., Beer R., Belda F., Bellander B., Belli A., Bellier R., Benali H., Benard T., Berardino M., Beretta L., Beynon C., Bilotta F., Binder H., Biqiri E., Blaabjerg M., Lund S., Bouzat P., Bragge P., Brazinova A., Brehar F., Brorsson C., Buki A., Bullinger M., Bucková V., Calappi E., Cameron P., Carbayo L., Carise E., Carpenter K., Castaño-León A., Causin F., Chevallard G., Chieregato A., Cooper M., Cnossen M., Coburn M., Coles J., Cooper J., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Damas F., Damas P., Dawes H., De Keyser V., Corte F., Depreitere B., Ding S., Dippel D., Dizdarevic K., Dulière G., Dzeko A., Eapen G., Engemann H., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V., Feng J., Foks K., Fossi F., Francony G., Frantzén J., Freo U., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gao G., Geleijns K., Ghuysen A., Giraud B., Glocker B., Gomez P., Grossi F., Gruen R., Gupta D., Haagsma J., Hadzic E., Haitsma I., Hartings J., Helbok R., Helseth E., Hertle D., Hill S., Hoedemaekers A., Hoefer S., Hutchinson P., Håberg K., Jacobs B., Janciak I., Janssens K., Jiang J., Jones K., Kalala J., Kamnitsas K., Karan M., Karau J., Katila A., Kaukonen M., Keeling D., Kerforne T., Ketharanathan N., Kettunen J., Kivisaari R., Kolias A., Kolumbán B., Kompanje E., Kondziella D., Koskinen L., Kovács N., Kálovits F., Lagares A., Lanyon L., Laureys S., Lauritzen M., Lecky F., Ledig C., Lefering R., Legrand V., Lei J., Levi L., Lightfoot R., Lingsma H., Loeckx D., Lozano A., Luddington R., Luijten-Arts C., Maas A., MacDonald S., MacFayden C., Maegele M., Majdan M., Major S., Manara A., Manhes P., Manley G., Martin D., Martino C., Maruenda A., Maréchal H., Mastelova D., Mattern J., McMahon C., Melegh B., Menon D., Menovsky T., Morganti-Kossmann C., Mulazzi D., Mutschler M., Mühlan H., Negru A., Nelson D., Neugebauer E., Newcombe V., Noirhomme Q., Nyirádi J., Oddo M., Oldenbeuving A., Oresic M., Ortolano F., Palotie A., Parizel P., Patruno A., Payen J., Perera N., Perlbarg V., Persona P., Peul W., Pichon N., Piilgaard H., Piippo A., Floury S., Pirinen M., Ples H., Polinder S., Pomposo I., Psota M., Pullens P., Puybasset L., Ragauskas A., Raj R., Rambadagalla M., Rehorcíková V., Rhodes J., Richardson S., Ripatti S., Rocka S., Rodier N., Roe C., Roise O., Roks G., Romegoux P., Rosand J., Rosenfeld J., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rostalski T., Rueckert D., de Ruiz A., Rusnák M., Sacchi M., Sahakian B., Sahuquillo J., Sakowitz O., Sala F., Sanchez-Pena P., Sanchez-Porras R., Sandor J., Santos E., Sasse N., Sasu L., Savo D., Schipper I., Schlößer B., Schmidt S., Schneider A., Schoechl H., Schoonman G., Rico F., Schwendenwein E., Schöll M., Sir ö., Skandsen T., Smakman L., Smeets D., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stegemann K., Steinbüchel N., Stevens R., Stewart W., Steyerberg E., Stocchetti N., Sundström N., Synnot A., Szabó J., Söderberg J., Taccone F., Tamás V., Tanskanen P., Tascu A., Taylor M., Te A., Tenovuo O., Teodorani G., Theadom A., Thomas M., Tibboel D., Tolias C., Tshibanda J., Tudora C., Vajkoczy P., Valeinis E., Hecke W., Praag D., Dirk V., Vlierberghe E., Vyvere T., Vanhaudenhuyse A., Vargiolu A., Vega E., Verheyden J., Vespa P., Vik A., Vilcinis R., Vizzino G., Vleggeert-Lankamp C., Volovici V., Vulekovic P., Vámos Z., Wade D., Wang K., Wang L., Wildschut E., Williams G., Willumsen L., Wilson A., Wilson L., Winkler M., Ylén P., Younsi A., Zaaroor M., Zhang Z., Zheng Z., Zumbo F., de Lange S., de Ruiter G., den Boogert H., van Dijck J., van Essen T., van Heugten C., van der Jagt M., van der Naalt J., Volovici V., van der Jagt M., Huijben J., Cnossen M., van der Naalt J., van der Jagt M., van Heugten C.
(A1 Refereed original research article in a scientific journal)
- Digital Gaming for Improving the Functioning of People With Traumatic Brain Injury: Protocol of a Feasibility Study (2016) Välimäki M, Korkeila J, Kauppi K, Kaakinen JK, Holm S, Vahlo J, Tenovuo O, Hämäläinen H, Sarajuuri J, Rantanen P, Orenius T, Koponen A
(A1 Refereed original research article in a scientific journal)
- Elevated blood GFAP and UCH-L1 levels in acute orthopaedic injuries without CNS involvement (2016) Posti J, Hossain I, Takala R, Liedes H, Newcombe V, Outtrim J, Katila A, Frantzen J, Ala-Seppala H, Coles J, Kyllonen A, Maanpaa HR, Tallus J, Hutchinson P, van Gils M, Menon D, Tenovuo O
(Other publication)
- Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury (2016) Takala RSK, Posti JP, Runtti H, Newcombe VF, Outtrim J, Katila AJ, Frantzen J, Ala-Seppala H, Kyllonen A, Maanpaa HR, Tallus J, Hossain MI, Coles JP, Hutchinson P, van Gils M, Menon DK, Tenovuo O
(A1 Refereed original research article in a scientific journal)
- Injury profiles, demography and representativeness of patients with TBI attending a regional emergency department (2016) Ala-Seppala H, Heino I, Frantzen J, Takala RSK, Katila AJ, Kyllonen A, Maanpaa HR, Posti JP, Tallus J, Tenovuo O
(A1 Refereed original research article in a scientific journal)
- Peripheral nervous system involvement in primary burning mouth syndromeresults of a pilot study (2016) Puhakka A, Forssell H, Soinila S, Virtanen A, Roytta M, Laine M, Tenovuo O, Teerijoki-Oksa T, Jaaskelainen SK
(A1 Refereed original research article in a scientific journal)
- Pohjoismainen hoitosuositus avuksi pään vammojen arviointiin (2016) Luoto T, Tenovuo O
(D1 Article in a professional journal)
- Prediction of Outcome after Traumatic Brain Injury: Comparison of Disease State Index and IMPACT Calculator (2016)
- Studies in Health Technology and Informatics
Liedes H, Mattila J, Lingsma H, Lötjönen J, Menon D, Tenovuo O, van Gils M
(A1 Refereed original research article in a scientific journal)
- Reproducibility of Tract-based and Region-of-Interest DTI Analysis of Long Association Tracts (2016) Brandstack N., Kurki T., Laalo J., Kauko T., Tenovuo O.
(A1 Refereed original research article in a scientific journal)
- Scandinavian guidelines for initial management of minor and moderate head trauma in children (2016) Astrand R, Rosenlund C, Undén J; and for the Scandinavian Neurotrauma Committee (SNC)
(A1 Refereed original research article in a scientific journal)
- The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury (2016)
- Current Pharmaceutical Design
Uteshev VV, Tenovuo O, Gaidhani N
(A1 Refereed original research article in a scientific journal)
- The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings (2016) Posti JP, Takala RSK, Runtti H, Newcombe VF, Outtrim J, Katila AJ, Frantzen J, Ala-Seppala H, Coles JP, Hossain MI, Kyllonen A, Maanpaa HR, Tallus J, Hutchinson PJ, van Gils M, Menon DK, Tenovuo O
(A1 Refereed original research article in a scientific journal)
- Variation in structure and process of care in traumatic brain injury: Provider profiles of European Neurotrauma Centers participating in the CENTER-TBI study (2016) Cnossen M., Polinder S., Lingsma H., Maas A., Menon D., Steyerberg E., Adams H., Alessandro M., Allanson J., Amrein K., Andaluz N., Andelic N., Andrea N., Andreassen L., Anke A., Antoni A., Ardon H., Audibert G., Auslands K., Azouvi P., Baciu C., Bacon A., Badenes R., Baglin T., Bartels R., Barzó P., Bauerfeind U., Beer R., Belda F., Bellander B., Belli A., Bellier R., Benali H., Benard T., Berardino M., Beretta L., Beynon C., Bilotta F., Binder H., Biqiri E., Blaabjerg M., Borgen L., Bouzat P., Bragge P., Brazinova A., Brehar F., Brorsson C., Buki A., Bullinger M., Bučková V., Calappi E., Cameron P., Carbayo L., Carise E., Carpenter C., Castaño-León A., Causin F., Chevallard G., Chieregato A., Citerio G., Coburn M., Coles J., Cooper J., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Damas F., Damas P., Dawes H., De Keyser V., Della Corte F., Depreitere B., Ding S., Dippel D., Dizdarevic K., Dulière G., Dzeko A., Eapen G., Engemann H., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V., Feng J., Foks K., Fossi F., Francony G., Frantzén J., Freo U., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gao G., Geleijns K., Ghuysen A., Giraud B., Glocker B., Gomez P., Grossi F., Gruen R., Gupta D., Haagsma J., Hadzic E., Haitsma I., Hartings J., Helbok R., Helseth E., Hertle D., Hill S., Hoedemaekers A., Hoefer S., Hutchinson P., Håberg A., Jacobs B., Janciak I., Janssens K., Jiang J., Jones K., Kalala J., Kamnitsas K., Karan M., Karau J., Katila A., Kaukonen M., Keeling D., Kerforne T., Ketharanathan N., Kettunen J., Kivisaari R., Kolias A., Kolumbán B., Kompanje E., Kondziella D., Koskinen L., Kovács N., Kálovits F., Lagares A., Lanyon L., Laureys S., Lauritzen M., Lecky F., Ledig C., Lefering R., Legrand V., Lei J., Levi L., Lightfoot R., Lingsma H., Loeckx D., Lozano A., Luddington R., Luijten-Arts C., Maas A., MacDonald S., MacFayden C., Maegele M., Majdan M., Major S., Manara A., Manhes P., Manley G., Martin D., Martino C., Maruenda A., Maréchal H., Mastelova D., Mattern J., McMahon C., Melegh B., Menovsky T., Morganti-Kossmann C., Mulazzi D., Mutschler M., Mühlan H., Negru A., Nelson D., Neugebauer E., Newcombe V., Noirhomme Q., Nyirádi J., Oddo M., Oldenbeuving A., Oresic M., Ortolano F., Palotie A., Parizel P., Patruno A., Payen J., Perera N., Perlbarg V., Persona P., Peul W., Pichon N., Piilgaard H., Piippo A., Pili F., Pirinen M., Ples H., Pomposo I., Psota M., Pullens P., Puybasset L., Ragauskas A., Raj R., Rambadagalla M., Rehorčíková V., Rhodes J., Richardson S., Ripatti S., Rocka S., Rodier N., Roe C., Roise O., Roks G., Romegoux P., Rosand J., Rosenfeld J., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rostalski T., Rueckert D., Ruiz De Arcaute F., Rusnák M., Sacchi M., Sahakian B., Sahuquillo J., Sakowitz O., Sala F., Sanchez-Pena P., Sanchez-Porras R., Sandor J., Santos E., Sasse N., Sasu L., Savo D., Schipper I., Schlößer B., Schmidt S., Schneider A., Schoechl H., Schoonman G., Schou R., Schwendenwein E., Schöll M., Sir Ö., Skandsen T., Smakman L., Smeets D., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Stegemann K., Steinbüchel N., Stevens R., Stewart W., Stocchetti N., Sundström N., Synnot A., Szabó J., Söderberg J., Taccone F., Tamás V., Tanskanen P., Tascu A., Taylor M., Te Ao B., Tenovuo O., Teodorani G., Theadom A., Thomas M., Tibboel D., Tolias C., Tshibanda J., Tudora C., Vajkoczy P., Valeinis E., Van Hecke W., Van Praag D., Van Roost D., Van Vlierberghe E., Vande Vyvere T., Vanhaudenhuyse A., Vargiolu A., Vega E., Verheyden J., Vespa P., Vik A., Vilcinis R., Vizzino G., Vleggeert-Lankamp C., Volovici V., Vulekovic P., Vámos Z., Wade D., Wang K., Wang L., Wildschut E., Williams G., Willumsen L., Wilson A., Wilson L., Winkler M., Ylén P., Younsi A., Zaaroor M., Zhang Z., Zheng Z., Zumbo F., De Lange S., De Ruiter G., Den Boogert H., Van Dijck J., Van Essen T., Van Heugten C., Van Der Jagt M., Van Der Naalt J., Polinder S., Cnossen M., Van Der Naalt J., Zumbo F., De Lange S., De Ruiter G., Den Boogert H., Van Dijck J., Van Essen T., Van Heugten C., Van Der Jagt M., Wilson L., Wilson A., Ylén P., Winkler M., Zaaroor M., Younsi A., Zheng Z., Zhang Z., Willumsen L.
(A1 Refereed original research article in a scientific journal)
- Clinical correlates of retrograde amnesia in mild traumatic brain injury (2015) Luoto TM, Iverson GL, Losoi H, Waljas M, Tenovuo O, Kataja A, Brander A, Ohman J
(A1 Refereed original research article in a scientific journal)
- Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): A Prospective Longitudinal Observational Study. (2015) Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A; on behalf of the CENTER-TBI Participants and Investigators
(A1 Refereed original research article in a scientific journal)
- Outcomes from mild and moderate traumatic brain injuries among children and adolescents: A systematic review of studies from 2008-2013 (2015) Lloyd J, Wilson ML, Tenovuo O, Saarijarvi S
(A2 Refereed review article in a scientific journal )
- Aivovammojen diagnostiikka on kehittymässä (2014) Kurki T, Tenovuo O
(D1 Article in a professional journal)
- Automatic Quantification of CT Images for Traumatic Brain Injury (2014)
- International Symposium on Biomedical Imaging
2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI) Koikkalainen J, Lotjonen J, Ledig C, Rueckert D, Tenovuo O, Menon D
(A4 Refereed article in a conference publication )
- Blood Metabolic Patterns Correlate With the Severity of Traumatic Brain Injury (2014) Jussi Posti, Tuulia Hyötyläinen, Sirkku Jäntti, Henna Ala-Seppälä, Jonathan Coles, Ari Katila, Anna Kyllönen, Henna-Riikka Maanpää, David K Menon, Joanne Outrim, Peter J Hutchinson, Keri Carpenter, Jussi Tallus, Marko Sysi-Aho, Riikka Takala, Matej Orea, Olli Tenovuo
(Other publication)
