Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- 68Ga-DOTA-Siglec-9 – a new imaging tool to detect synovitistis (2015)
- Arthritis Research and Therapy
(A1 Refereed original research article in a scientific journal) - Aberrant Circulating Levels of Purinergic Signaling Markers Are Associated With Several Key Aspects of Peripheral Atherosclerosis and Thrombosis (2015)
- Circulation Research
(A1 Refereed original research article in a scientific journal) - Age-, Sex- and glucose-dependent correlation of plasma soluble vascular adhesion protein-1 concentration with cardiovascular risk factors and subclinical atherosclerosis (2015)
- Atherosclerosis
(Other publication) - CD73 Activity is Dispensable for the Polarization of M2 Macrophages (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Ecto-5'-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature (2015)
- European Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Increased intravitreal adenosine 5′-triphosphate, adenosine 5′-diphosphate and adenosine 5′-monophosphate levels in patients with proliferative diabetic retinopathy (2015)
- Acta Ophthalmologica
(A1 Refereed original research article in a scientific journal) - Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Systemic Manifestations of Mucosal Diseases: Trafficking of Gut Immune Cells to Joint, Liver, and Pancreas (2015) Mucosal Immunology Salmi M, Adams DH, Trivedi P, Hänninen A, Jalkanen S
(A3 Refereed book chapter or chapter in a compilation book) - TGF-β1-induced epithelial–mesenchymal transition promotes monocyte/macrophage properties in breast cancer cells (2015)
- Frontiers in Oncology
(A1 Refereed original research article in a scientific journal) - The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection (2015)
- Cell Systems
(A1 Refereed original research article in a scientific journal) - The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes (2015)
- Nature Immunology
(A1 Refereed original research article in a scientific journal) - Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Uptake of 68Ga- and 18F-labelled Siglec-9 motif peptide tracers in atherosclerotic plaques (2015)
- Molecular Imaging and Biology
(Other publication) - Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis (2015)
- Journal of Clinical Investigation
(A1 Refereed original research article in a scientific journal) - (68)Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections (2014)
- EJNMMI Research
(A1 Refereed original research article in a scientific journal) - Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms. (2014)
- Molecular Cancer Research
(A1 Refereed original research article in a scientific journal) - Clever-1/stabilin-1 controls cancer growth and metastasis (2014)
- Clinical Cancer Research
(A1 Refereed original research article in a scientific journal) - Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs (2014)
- Mediators of Inflammation
(A1 Refereed original research article in a scientific journal) - Detection of atherosclerotic plaques with a novel vascular adhesion protein-1 targeting [18F]FDR-Siglec-9 peptide (2014)
- Journal of Nuclear Medicine
(Other publication) - Distribution and medical impact of loss-of-function variants in the Finnish founder population. (2014)
- PLoS Genetics
(A1 Refereed original research article in a scientific journal)